Results 61 to 70 of about 29,794,370 (246)

Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta. [PDF]

, 1991
Previously, we pointed out the importance of the kynurenine metabolism in fetuses and neonates. We examined localization and developmental change of indoleamine 2,3-dioxygenase activity in human placenta.
Eguchi, Katsuto, Yonezawa, Masaru, Kamimura, Shigehito, Sekiba, Kaoru   +3 more
core   +1 more source

Kynurenines as a Novel Target for the Treatment of Inflammatory Disorders

Cells
This review discusses the potential of targeting the kynurenine pathway (KP) in the treatment of inflammatory diseases. The KP, responsible for the catabolism of the amino acid tryptophan (TRP), produces metabolites that regulate various physiological ...
Adrian Mor, Anna Tankiewicz-Kwedlo, Marianna Ciwun, Janina Lewkowicz, Dariusz Pawlak   +4 more
doaj   +1 more source

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Journal of Medicinal Chemistry, 2015
Since the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) as an attractive target for anticancer therapy in 2003, the search for inhibitors has been intensely pursued both in academia and in pharmaceutical companies. Many novel IDO1 inhibitor scaffolds have been described, and a few potent compounds have entered clinical trials.
Roehrig, Ute F., Majjigapu, Somi Reddy, Vogel, Pierre, Zoete, Vincent, Michiein, Olivier   +4 more
openaire   +3 more sources

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Indoleamine 2,3-Dioxygenase 2 Immunohistochemical Expression in Resected Human Non-small Cell Lung Cancer: A Potential New Prognostic Tool

Frontiers in Immunology, 2020
Indoleamine 2,3-dioxygenase 2 (IDO2) is an analog of the tryptophan degrading and immunomodulating enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Although the role of IDO1 is largely understood, the function of IDO2 is not yet well-elucidated.
Martina Mandarano, Guido Bellezza, Maria Laura Belladonna, Jacopo Vannucci, Alessio Gili, Ivana Ferri, Chiara Lupi, Vienna Ludovini, Giulia Falabella, Giulio Metro, Giada Mondanelli, Rita Chiari, Lucio Cagini, Fabrizio Stracci, Fabrizio Stracci, Fausto Roila, Francesco Puma, Claudia Volpi, Angelo Sidoni   +18 more
doaj   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Indoleamine 2,3-dioxygenase-expressing CD11cdendritic cells display a phenotype consistent with the immature state

, 2011
Indoleamine 2,3-dioxygenase (IDO)CD11cdendritic cells (DCs) were stained for markers of DC maturity and were analyzed using three-color flow cytometry.
Young-Ok Jung (46883), Hyun-Sil Park (46884), Ho-Youn Kim (26636), Young-Gyu Cho (46881), Sung-Hwan Park (26633), So-Youn Min (46879), Min-Jung Park (46878), Mi-La Cho (46882), Kyung-Su Park (46880), Soog-Hee Chang (46885), Seok Goo Cho (46886), Jun-Ki Min (46887)   +11 more
core   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

sj-docx-1-try-10.1177_11786469231153111 – Supplemental material for Endothelial Indoleamine-2,3-Dioxygenase-1 is not Critically Involved in Regulating Antitumor Immunity in the Central Nervous System

, 2023
Supplemental material, sj-docx-1-try-10.1177_11786469231153111 for Endothelial Indoleamine-2,3-Dioxygenase-1 is not Critically Involved in Regulating Antitumor Immunity in the Central Nervous System by AP Abu Hejleh, K Huck, K Jähne, CL Tan, TV Lanz, L ...
CA Opitz (14597488), K Sahm (14597491), TV Lanz (14597473), JK Sonner (14597479), SG Meuth (14597482), C Herold-Mende (13538770), K Huck (14597464), F Sahm (13538773), A Henneberg (14597485), L Epping (14597476), AP Abu Hejleh (14597461), K Jähne (14597467), M Platten (13419852), CL Tan (14597470)   +13 more
core   +1 more source

Indoleamine 2,3-dioxygenase 1 expression predicts cholangiocarcinoma patient survival

Experimental and Molecular Pathology
Background: Cholangiocarcinoma (CCA) is a prevalent hepatobiliary disease in northeast Thailand, where late diagnosis and limited treatment options contribute to poor prognosis.
Mallika Naeklang, Hasaya Dokduang, Piya Prajumwongs, Poramate Klanrit, Arporn Wangwiwatsin, Nisana Namwat, Attapol Titapun, Prakasit Sa-Ngiamwibool, Watcharin Loilome   +8 more
doaj   +1 more source