Results 81 to 90 of about 29,794,370 (246)

Analysis of Reaction Intermediates in Tryptophan 2,3-Dioxygenase: A Comparison with Indoleamine 2,3-Dioxygenase

, 2016
Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) are heme-containing enzymes that catalyze the O2-dependent oxidation of l-tryptophan (l-Trp) in biological systems.
Elizabeth S. Booth (3369656), Jaswir Basran (1280517), Emma L. Raven (1270266), Sandeep Handa (1280511), Michael Lee (353518)   +4 more
core   +1 more source

Clinicopathological significance of indoleamine 2,3-dioxygenase 1 expression in colorectal cancer [PDF]

British Journal of Cancer, 2011
Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-catabolising enzyme that induces immune tolerance by modulating T-cell responses. Carcinomas may create an immunosuppressive state via IDO1 expression. Here we examined a possible contribution of IDO1 on this phenomenon and investigated whether IDO1 has prognostic value in colorectal cancer (CRC ...
Ferdinande, Liesbeth, Decaestecker, Christine, Verset, Laurine, Mathieu, A, Moles Lopez, Xavier, Negulescu, A.M., Van Maerken, T, Salmon, Isabelle, Cuvelier, C A, Demetter, Pieter   +9 more
openaire   +3 more sources

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Chemotherapy-Dependent ATP Release from Leukemia Dying Cells Induces Indoleamine 2,3-Dioxygenase 1 in Dendritic Cells

, 2016
Chemotherapy-Dependent ATP Release from Leukemia Dying Cells Induces Indoleamine 2,3-Dioxygenase 1 in Dendritic ...
Romero, P, S Trabanelli, C Bontadini, Redavid A, S . Jandus, Adinolfi, E, Di Virgilio F., Ocadlikova D, E Sangaletti, Lecciso, M, Martinelli G, De Marchi, Colombo, Cavo, M, Curti, A, E Orioli   +15 more
core   +1 more source

Genetic deficiency of Indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health [PDF]

, 2018
International audienceThe association between altered gut microbiota, intestinal permeability, inflammation and cardiometabolic diseases is becoming increasingly clear but remains poorly understood1,2.
Sarvenaz Metghalchi, Haddad, Y, Metghalchi, S, Cardellini, M, Bertrand Tavitian, Esposito B., Alzaid, Fawaz, Esposito, Bruno, Dairou J., Esposito, B, Alain Tedgui, Callebert J., Burcelin, Remy, Moreno-Navarrete J. -M., Yacine Haddad, Dairou, J, Viel, T, Callebert, J, Chajadine M., Fernandez-Real, Jm, Tedgui, Alain, Denis, Rgp, Luquet, Serge, Fernandez-Real, José Manuel, Viel, Thomas, Burcelin, R, Venteclef, N, Sokol H., Serge H. Luquet, Jean-Marie Launay, Mouna Chajadine, Federici, Massimo, Taleb S., Haddad, Yacine, Tedgui A., Nicolas Venteclef, Cardellini M., Tavitian, B, Burcelin R., Tavitian B., Jégou, Sarah, Straub M., Luquet, Sh, Launay J. -M., Cardellini, Marina, Jacques Callebert, Federici M., Raphael G. P. Denis, Alzaid, F, Callebert, Jacques, Metghalchi S., McQuitty C., Tedgui, A, Mallat, Z, Bruno Esposito, Marjolene Straub, Straub, Marjolene, Mcquitty, C, Remy Burcelin, Venteclef, Nicolas, Laurans, Ludivine, Tavitian, Bertrand, Soraya Taleb, Denis R. G. P., Moreno-Navarrete, J-, Taleb, S, Taleb, Soraya, Luquet S. H., Mcquitty, Claire, Denis, Raphael, Massimo Federici, Mallat Z., Ziad Mallat, Laurans L., José Manuel Fernandez-Real, Bruno Sovran, Sovran B., Viel T., Marina Cardellini, Alzaid F., Jegou S., Sovran, B, Launay, Jean-Marie, Jegou, S, Laurans, L, Mallat, Ziad, Federici, M, Sovran, Bruno, Claire McQuitty, Straub, M, Julien Dairou, Chajadine, Mouna, Fawaz Alzaid, Jose-Maria Moreno-Navarrete, Thomas Viel, Venteclef N., Launay, J-, Moreno-Navarrete, Jose-Maria, Haddad Y., Metghalchi, Sarvenaz, Sokol, Harry, Chajadine, M, Sokol, H, Fernandez-Real J. M., Ludivine Laurans, Harry Sokol, Dairou, Julien, Sarah Jegou   +107 more
core   +2 more sources

Biological and clinical significance of tryptophan-catabolizing enzymes in cutaneous T-cell lymphomas

OncoImmunology, 2017
Indoleamine 2,3-deoxygenase 1 (IDO1) induces immune tolerance in the tumor microenvironment (TME) and is recognized as a potential therapeutic target.
Pilvi Maliniemi, Kirsi Laukkanen, Liisa Väkevä, Katja Dettmer, Tuomas Lipsanen, Leila Jeskanen, Alban Bessede, Peter J. Oefner, Marshall E. Kadin, Annamari Ranki   +9 more
doaj   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Serotonin neuromicrobiology: Psychobiotic modulation of the gut–brain axis for mental health

Ibrain, EarlyView.
An overview of Psychobiotics and Tryptophan metabolism: A serotonin‐kynurenine crosstalk shaping the Gut‐Brain axis. IDO1, Indoleamine 2,3‐dioxygenase 1; 5‐HT3, 5‐hydroxytryptamine type 3; IFN‐γ, Interferon‐gamma; TNF‐α, Tumor necrosis factor‐alpha; IL‐1β, Interleukin‐1 beta; IL‐6, Interleukin 6; Trp, Tryptophan; 5‐HT, 5‐hydroxy‐tryptamine; 5‐HTP, 5 ...
Nidhi Mandloi, Aarzoo, Chakkaravarthi Saravanan, Heera Ram, Bhim Pratap Singh   +4 more
wiley   +1 more source

Nanomedicine and cancer immunotherapy: Focus on indoleamine 2,3-dioxygenase inhibitors

, 2017
Nanomedicine application in cancer immunotherapy is currently one of the most challenging areas in cancer therapeutic intervention. Innovative solutions have been provided by nanotechnology to deliver cytotoxic agents to the cancer cells partially ...
Farooq, RK, Mahroo, A, Zulfiqar, B, Jalal, N, Rashid, MU, Nasir, K, Asghar, K   +6 more
core   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source