Results 71 to 80 of about 29,794,370 (246)

Indoleamine 2,3-dioxygenase 1 is highly expressed in glioma stem cells

Biochemical and Biophysical Research Communications, 2020
Recent research has revealed that glioblastoma (GBM) avoids the immune system via strong expression of indoleamine 2,3-dioxygenase 1 (IDO1). IDO1, an enzyme involved in tryptophan metabolism, is now proposed as a new target in GBM treatment, since several reports have demonstrated that IDO1 expression is related to GBM malignancy. On the other hand, it
Yoshinari Ozawa, Shun Yamamuro, Emiko Sano, Juri Tatsuoka, Yuya Hanashima, Sodai Yoshimura, Koichiro Sumi, Hiroyuki Hara, Tomohiro Nakayama, Yutaka Suzuki, Atsuo Yoshino   +10 more
openaire   +2 more sources

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Degradation of Chloroaromatics: Purification and Characterization of a Novel Type of Chlorocatechol 2,3-Dioxygenase of Pseudomonas putida GJ31 [PDF]

, 1998
A purification procedure for a new kind of extradiol dioxygenase, termed chlorocatechol 2,3-dioxygenase, that converts 3-chlorocatechol productively was developed.
Kasberg, Thomas,, Kaschabek, Stefan R., Müller, Dagmar,, Mars, Astrid E.,, Mars, Astrid E., Janssen, Dick B., Reineke, Walter,, Müller, Dagmar, Reineke, Walter, Kaschabek, Stefan R.,, Kasberg, Thomas, Janssen, Dick B.,   +11 more
core   +1 more source

Discovery of Icotinib-1,2,3-Triazole Derivatives as IDO1 Inhibitors

Frontiers in Pharmacology, 2020
Tumor immunotherapy is considered to be a highlight in cancer treatment in recent years. Indoleamine 2,3-dioxygenase 1 (IDO1) is closely related to the over expression of many cancers, and is therefore a promising target for tumor immunotherapy.
Long-fei Mao, Long-fei Mao, Yu-wei Wang, Jie Zhao, Gui-qing Xu, Xiao-jun Yao, Yue-Ming Li   +6 more
doaj   +1 more source

Indoleamine-2,3-dioxygenase-related anti-inflammatory effects of 3-aminobenzamide and infliximab in experimental colitis

, 2022
OBJECTIVE: This study aimed to investigate the presence of indoleamine-2,3-dioxygenase and bacterial translocation after the administration of 3-aminobenzamide and infliximab in the TNBS modelofratcolitis.METHODS: The study group was divided into five ...
Özkan, YEŞİM, Dolapci, Mete, Aydin, Oguz Ugur, Sahin, Duygu, Sepici Dinçel, Aylin, Akca, Gülçin, Aydin, Sezai, Menekse, Ebru, Eroglu, Abdullah   +8 more
core   +1 more source

Involvement of the kynurenine pathway in human glioma pathophysiology.

PLoS ONE, 2014
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants, kynurenic acid (KYNA) and picolinic acid (PIC), the excitotoxin, quinolinic acid (QUIN) and the ...
Seray Adams, Charles Teo, Kerrie L McDonald, Anna Zinger, Sonia Bustamante, Chai K Lim, Gayathri Sundaram, Nady Braidy, Bruce J Brew, Gilles J Guillemin   +9 more
doaj   +1 more source

Recent advances in the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

MedChemComm, 2019
This review summarizes the recent development of IDO1 inhibitors, focusing on structures, enzymatic inhibitory activity, selectivity and other biological activities.
Xiu-Xiu Wang, Si-Yu Sun, Qing-Qing Dong, Xiao-Xiang Wu, Wei Tang, Ya-Qun Xing   +5 more
openaire   +3 more sources

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source