Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine [PDF]
Virology Journal, 2008 Background The vaccinia virus (VV) F2L gene encodes a functional deoxyuridine triphosphatase (dUTPase) that catalyzes the conversion of dUTP to dUMP and is thought to minimize the incorporation of deoxyuridine residues into the viral genome.
Moyer Richard W +5 more
doaj +4 more sources
Historical Perspectives in the Development of Antiviral Agents Against Poxviruses [PDF]
Viruses, 2010 The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the ...
Erik De Clercq
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Determination of Iodide and Idoxuridine at a Glutaraldehyde-Cross-Linked Poly-L-Lysine Modified Glassy Carbon Electrode [PDF]
, 2005 The detection limit (about 0.017 mu g mL(-1)) for voltammetric determination of iodide (peak at +0.87 V vs. Ag/AgCl at pH 2) at a glutaraldehyde-cross-linked poly-L-lysine modified glassy carbon electrode involving oxidation to iodine was found to be ...
.Papac +43 more
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bioRxiv, 2023 Stochastic fluctuations (noise) in transcription generate substantial cell-to-cell variability, but the physiological roles of noise have remained difficult to determine in the absence of generalized noise-modulation approaches.
Giuliana P. Calia +3 more
semanticscholar +1 more source
Treatment of eczema herpeticum with acyclovir [PDF]
, 1983 Contains fulltext : 4421.pdf (publisher's version ) (Open ...
Enschedé, F.A.J. +4 more
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Анализ рынка фармацевтических препаратов для лечения вирусных конъюнктивитов [PDF]
, 2016 Приведена сравнительная характеристика фармацевтических препаратов и обзор их фармакологического действия на различные виды возбудителей вирусных ...
Баскакова, А. В. +3 more
core +2 more sources
Modern approaches to the treatment of herpetic infection in children
Aktualʹnaâ Infektologiâ, 2019 It is currently known 8 pathogenic herpesviruses: two types of herpes simplex virus (HSV-1, HSV-2), varicella zoster virus, Epstein-Barr virus, cytomegalovirus, HHV-6, HHV-7, and HHV-8.
S.O. Kramarov, V.V. Yevtushenko
doaj +1 more source
Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel? [PDF]
, 2012 Herpes simplex keratitis (HSK) is a major cause of corneal blindness in the world. Following the primary infection, the virus enters into a latent phase.
Hamrah, Pedram, Sahin, Afsun
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Herpes simplex keratitis: Challenges in diagnosis and clinical management [PDF]
, 2017 Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a ...
Azher, Tayaba N +4 more
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Liposomes as delivery systems in the prevention and treatment of infectious diseases [PDF]
, 1995 Research on the potential application of liposomes in the prevention and treatment of infectious diseases has focussed on improvement of the therapeutic index of antimicrobial drugs and immunomodulators and on stimulation of the immune response to ...
Bakker-Woudenberg, I.A.J.M. (Irma) +3 more
core +1 more source