Results 31 to 40 of about 1,980 (168)

Historical Perspectives in the Development of Antiviral Agents Against Poxviruses

Viruses, 2010
The poxvirus vaccinia virus (VV) served as the model virus for which the first antivirals, the thiosemicarbazones, were identified. This dates back to 1950; and, although there is at present no single antiviral drug specifically licensed for the ...
Erik De Clercq
doaj   +1 more source

Modern approaches to the treatment of herpetic infection in children

Aktualʹnaâ Infektologiâ, 2019
It is currently known 8 pathogenic herpesviruses: two types of herpes simplex virus (HSV-1, HSV-2), varicella zoster virus, Epstein-Barr virus, cytomegalovirus, HHV-6, HHV-7, and HHV-8.
S.O. Kramarov, V.V. Yevtushenko
doaj   +1 more source

A systematic review and meta-analysis to compare the efficacy of acyclovir 3% ophthalmic ointment to idoxuridine in curing herpetic keratitis by Day 7 of treatment

BMC Ophthalmology, 2015
BackgroundThis objective of the review and analysis is to demonstrate that acyclovir (ACV) 3% ophthalmic ointment is superior to idoxuridine (IDU) in treating herpetic keratitis (HK) presenting as dendritic and geographic ulcer sub-types.MethodsData ...
D. Balderson, Gengqian Cai, M. Fries, D. M. Kleinman, M. McLaughlin, Trupti M Trivedi, J. Wurzelmann, S. Young   +7 more
semanticscholar   +1 more source

The 2023 World Small Animal Veterinary Association (WSAVA)

, 2023
Journal of Small Animal Practice, Volume 64, Issue 12, Page 731-748, December 2023.
P. V. Steagall, L. Pelligand, S. Page, J. L. Granick, F. Allerton, P. M. Bęczkowski, J. S. Weese, A. K. Hrček, F. Queiroga, L. Guardabassi   +9 more
wiley   +1 more source

One-pot biosynthesis of idoxuridine using nanostabilized lactic acid bacteria

, 2017
An efficient bioprocess using immobilized lactic acid bacteria to obtain 5-iodouracil-2′-deoxyriboside, known as idoxuridine, is reported. This nucleoside analogue is an antiviral agent used in the treatment of viral infections in the absence of ...
V. Cappa, J. Trelles
semanticscholar   +1 more source

Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine

Virology Journal, 2008
Background The vaccinia virus (VV) F2L gene encodes a functional deoxyuridine triphosphatase (dUTPase) that catalyzes the conversion of dUTP to dUMP and is thought to minimize the incorporation of deoxyuridine residues into the viral genome.
Moyer Richard W, Keith Kathy A, Quenelle Debra C, Kern Earl R, Prichard Mark N, Turner Peter C   +5 more
doaj   +1 more source

Formulation and Evaluation of Ocusert Idoxuridine

, 2017
Ophthalmic insert is defined as sterile preparation with solid or semisolid consisting and whose size and shape are especially designed for ophthalmic application.
B. Dwivedi, R. Yadav, Priyanka Arjariya, M. Goyal   +3 more
semanticscholar   +1 more source

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

The Use of Methylsulfonylmethane‐Containing Products in Dermatology: An Evidence‐Based Systematic Review of Safety and Efficacy

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Methylsulfonylmethane (MSM) is a biologically active sulfur compound that has been implicated in structural protein synthesis and anti‐inflammatory signaling pathways. We conducted a systematic review to evaluate the efficacy and safety of MSM in skin care products and explore the underlying mechanism of action.
Nana-Hawwa Abdul-Rahman, Lucie Joerg, Jacqueline D. Wang, Sonal Choudhary, Suraiya Saleem   +4 more
wiley   +1 more source

Evaluating the Potential Adverse Effects of Favipiravir on Biochemical, Histopathological, and Spermatological Parameters in Male Rats' Testicular Tissue

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
ABSTRACT Favipiravir is a selective RNA polymerase inhibitor and a broad‐spectrum antiviral drug. Favipiravir reduces cell proliferation by inhibiting RNA transcription, particularly in rapidly proliferating cells such as spermatogonia. The aim of this study was to investigate the effects and mechanism of action of favipiravir (T‐705) on sperm quality ...
Ali Doğan Ömür, Gamze Uçak, Adem Kara, Elif Erbaş, Serkan Ali Akarsu, Seçkin Özkanlar, Nevra Aydemir Celep   +6 more
wiley   +1 more source