Results 21 to 30 of about 1,980 (168)

Comparative analysis between single-cell RNA-seq and single-molecule RNA FISH indicates that the pyrimidine nucleobase idoxuridine (IdU) globally amplifies transcriptional noise

bioRxiv, 2023
Stochastic fluctuations (noise) in transcription generate substantial cell-to-cell variability, but the physiological roles of noise have remained difficult to determine in the absence of generalized noise-modulation approaches.
Giuliana P. Calia, Xinyue Chen, Binyamin Zuckerman, L. Weinberger   +3 more
semanticscholar   +1 more source

VP37 Protein Inhibitors for Mpox Treatment: Highlights on Recent Advances, Patent Literature, and Future Directions

Biomedicines, 2023
Monkeypox disease (Mpox) has threatened humankind worldwide since mid-2022. The Mpox virus (MpoxV) is an example of Orthopoxviruses (OPVs), which share similar genomic structures. A few treatments and vaccines are available for Mpox.
Shuaibu A. Hudu, Ahmed S. Alshrari, Aiman Al Qtaitat, Mohd Imran   +3 more
doaj   +1 more source

Detection of Ursid Gammaherpesvirus 2 in Asiatic Black Bears (Ursus thibetanus) With Keratoconjunctivitis. [PDF]

Vet Ophthalmol
ABSTRACT Objective To investigate the potential contribution of herpesvirus infection in the development of ocular surface disease in Asiatic black bears (Ursus thibetanus). Animals Studied Eight captive Asiatic black bears housed at a wildlife sanctuary were examined during routine health assessments.
Thieme K, Gölkel M, Eule JC, Halter-Gölkel L, Kunec D, Göritz F, Feyer S, Bui BN, Trimpert J.   +8 more
europepmc   +2 more sources

Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism. [PDF]

PLoS ONE, 2012
To identify interactions a nucleoside analog library (NAL) consisting of 45 FDA-approved nucleoside analogs was screened against 23 enzymes of the human nucleotide metabolism using a thermal shift assay. The method was validated with deoxycytidine kinase;
Louise Egeblad, Martin Welin, Susanne Flodin, Susanne Gräslund, Liya Wang, Jan Balzarini, Staffan Eriksson, Pär Nordlund   +7 more
doaj   +1 more source

The characteristics of excitatory lineage differentiation and the developmental conservation in Reeler neocortex. [PDF]

Cell Prolif
The differentiation process in lineage is illustrated by sparse labelling. 93.03% of neuronal production are mediated by intermediate progenitor cells. Half of intermediate progenitor cells at first generation are proliferative and contribute to part of superficial neurons. The intermediate proliferative progenitor cells express high level of Cux2. The
Deng HH, Tong SY, Shen D, Zhang SQ, Fu Y.   +4 more
europepmc   +2 more sources

Utilising cottonseed in animal feeding: A dialectical perspective

Modern Agriculture, Volume 1, Issue 2, Page 112-121, September 2023., 2023
This paper discusses the potential application of cottonseed as a feed source. Glandless cottonseed, devoid of gossypol, can be utilised as a regular livestock feed following appropriate processing methods. Cottonseed containing gossypol, particularly (+)‐gossypol, can serve as a short‐term ‘medicinal‐feeding homologous’ feed to prevent or treat viral ...
Wenjing Wang, Jun Li, Juncheng Liu, Maozhi Ren, Fuguang Li   +4 more
wiley   +1 more source

Antiviral Activity of 4'-thioIDU and Thymidine Analogs against Orthopoxviruses

Viruses, 2010
The search for effective therapies for orthopoxvirus infections has identified diverse classes of molecules with antiviral activity. Pyrimidine analogs, such as 5-iodo-2'-deoxyuridine (idoxuridine, IDU) were among the first compounds identified with ...
Mark N. Prichard, Earl R. Kern
doaj   +1 more source

Neonatal herpes simplex virus infection: From the maternal infection to the child outcome

Journal of Medical Virology, Volume 95, Issue 8, August 2023., 2023
Abstract This review examines the recent literature on the management of herpes simplex virus (HSV) infections in neonates. We summarized the three clinical categories of maternal HSV infection during pregnancy (primary first episode, nonprimary first episode, or recurrent episode) and the mechanisms of fetal damage.
Domenico Umberto De Rose, Sarah Bompard, Chiara Maddaloni, Iliana Bersani, Ludovica Martini, Alessandra Santisi, Daniela Longo, Maria Paola Ronchetti, Andrea Dotta, Cinzia Auriti   +9 more
wiley   +1 more source

Research Progress in HIV and Mycobacterium tuberculosis Inhibitors Containing Sulfonamide Moiety

Journal of Chemistry, Volume 2023, Issue 1, 2023., 2023
Numerous studies have reported significant results regarding the efficacy of sulfonamides against Mycobacterium tuberculosis and various HIV strains. This scientific paper provides an overview of the progress made over a decade of sulfonamides against HIV‐1 and mycobacteria and its development against extremely drug‐resistant (XDR) and multidrug ...
Christiana Abimbola Salubi, Vijay Kumar Siripuram   +1 more
wiley   +1 more source

Combination Therapy of Ledipasvir and Itraconazole in the Treatment of COVID‐19 Patients Coinfected with Black Fungus: An In Silico Statement

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
The manuscript mainly aimed at providing clues on improving the innate immunity of coronavirus patients and safeguarding them from both new mutant strains and black fungus infections. Coronavirus is readily mutating from one variant to another. Among the several variants, we selected SARS‐CoV‐2 B.1.1.7 in this study.
Supriyo Saha, Gyu Seong Yeom, Satish Balasaheb Nimse, Dilipkumar Pal, Mohammad Hassan Baig   +4 more
wiley   +1 more source