Assessment of Cidofovir for Treatment of Ocular Bovine Herpesvirus-1 Infection in Cattle Using an Ex-Vivo Model [PDF]
Viruses, 2021 Bovine herpesvirus-1 (BoHV-1) infection contributes to keratoconjunctivitis, respiratory disease, and reproductive losses in cattle. The objective of this study was to determine the most appropriate ophthalmic antiviral agent for BoHV-1 inhibition using ...
Christopher R. Alling +6 more
doaj +2 more sources
Nanoindentation of HMX and Idoxuridine to Determine Mechanical Similarity
Crystals, 2017 Assessing the mechanical behavior (elastic properties, plastic properties, and fracture phenomena) of molecular crystals is often complicated by the difficulty in preparing samples.
Alexandra C. Burch +2 more
doaj +2 more sources
Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease. [PDF]
PLoS ONEInduction of fetal hemoglobin (HbF) has been shown to be a viable therapeutic approach to treating sickle cell disease and potentially other β-hemoglobinopathies.
Jian-Ping Yang +11 more
doaj +2 more sources
A Screening Study Identified Decitabine as an Inhibitor of Equid Herpesvirus 4 That Enhances the Innate Antiviral Response [PDF]
VirusesEquid herpesvirus 4 (EHV-4) is a common respiratory pathogen in horses. It sporadically induces abortion or neonatal death. Although its contribution in neurological disorders is not clearly demonstrated, there is a strong suspicion of its involvement ...
Camille Normand +9 more
doaj +2 more sources
Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase. [PDF]
PLoS PathogensLumpy skin disease (LSD) is an emerging transboundary disease caused by lumpy skin disease virus (LSDV), posing significant threats to global cattle health in the absence of validated drugs. Here, we constructed a recombinant LSDV (rLSDV) expressing both
Zuxin Gong +10 more
doaj +2 more sources
Recalcitrant giant orf recurrence after amputation: A case report and review of the literature. [PDF]
Clin Case Rep, 2022 Orf disease might recur even after digital amputation in immunesuppressed patients and topical imiquimod cream in conjunction with systemic subcutaneous interferon alfa‐2a is a good treatment option. Abstract Orf is caused by a parapoxvirus. We present a recurrent, giant digital orf case in a female patient with a history of hairy cell leukemia.
Saeidi V +3 more
europepmc +2 more sources
Definitions, 2020 An iodinated analogue of deoxyuridine, with antiviral activity against herpes simplex virus (HSV) and potential radiosensitizing activities. Upon ocular administration, idoxuridine (IUdR) is converted to its mono-, di-, and triphosphate forms, is ...
openaire +2 more sources
IDOXURIDINE FOR HERPES ZOSTER [PDF]
Lancet, The, 1980 V. Esmann, K.E. Wildenhoff
exaly +5 more sources
Prevalence and Clinical Impacts of Canine Herpesvirus-1 (CHV-1) in Dogs: A Review of Reproductive Effects and Ocular Lesions. [PDF]
Vet Med SciTaxonomy: Herpesviridae, Alphaherpesvirinae and Varicellovirus. Diagnosis: PCR for genetic detection. Transmission: Birth, venereal and transplacental. Pathogenesis: Ocular lesions; blepharitis, conjunctivitis and ulcerative and non‐ulcerative keratitis.
Soleimani S +4 more
europepmc +2 more sources
Identification and validation of basement membrane-associated gene AGRN as prognostic and immune-associated biomarkers in colorectal cancer patients. [PDF]
J Cell Mol MedAbstract Colorectal cancer (COCA) has a poor prognosis, with growing evidence implicating basement membranes (BMs) in cancer progression. Our goal was to investigate the role and predictive significance of BMs in COCA patients. We obtained BMs‐related genes from cutting‐edge research and used TCGA and GTEx databases for mRNA expression and patient ...
Li J, You D, Hu L, Yang Y, Gao S, Bai W.
europepmc +2 more sources