Results 31 to 40 of about 12,364 (188)

Primary cilia are not required for normal canonical Wnt signaling in the mouse embryo. [PDF]

PLoS ONE, 2009
Sonic hedgehog (Shh) signaling in the mouse requires the microtubule-based organelle, the primary cilium. The primary cilium is assembled and maintained through the process of intraflagellar transport (IFT) and the response to Shh is blocked in mouse ...
Polloneal Jymmiel R Ocbina, Miquel Tuson, Kathryn V Anderson   +2 more
doaj   +1 more source

Testing the ion-current model for flagellar length sensing and IFT regulation

eLife, 2023
Eukaryotic cilia and flagella are microtubule-based organelles whose relatively simple shape makes them ideal for investigating the fundamental question of organelle size regulation.
Hiroaki Ishikawa, Jeremy Moore, Dennis R Diener, Markus Delling, Wallace F Marshall   +4 more
doaj   +1 more source

The GTPase IFT27 is involved in both anterograde and retrograde intraflagellar transport

eLife, 2014
The construction of cilia and flagella depends on intraflagellar transport (IFT), the bidirectional movement of two protein complexes (IFT-A and IFT-B) driven by specific kinesin and dynein motors.
Diego Huet, Thierry Blisnick, Sylvie Perrot, Philippe Bastin   +3 more
doaj   +1 more source

IFT trains in different stages of assembly queue at the ciliary base for consecutive release into the cilium

eLife, 2017
Intraflagellar transport (IFT) trains, multimegadalton assemblies of IFT proteins and motors, traffic proteins in cilia. To study how trains assemble, we employed fluorescence protein-tagged IFT proteins in Chlamydomonas reinhardtii.
Jenna L Wingfield, Ilaria Mengoni, Heather Bomberger, Yu-Yang Jiang, Jonathon D Walsh, Jason M Brown, Tyler Picariello, Deborah A Cochran, Bing Zhu, Junmin Pan, Jonathan Eggenschwiler, Jacek Gaertig, George B Witman, Peter Kner, Karl Lechtreck   +14 more
doaj   +1 more source

Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis.

PLoS Genetics, 2017
Intraflagellar transport (IFT) particles or trains are composed of IFT-A and IFT-B complexes. To assess the working mechanism of the IFT-A complex in IFT and ciliogenesis, we have analyzed ift43 mutants of Chlamydomnonas in conjunction with mutants of ...
Bing Zhu, Xin Zhu, Limei Wang, Yinwen Liang, Qianqian Feng, Junmin Pan   +5 more
doaj   +1 more source

The roles of intraflagellar transport (IFT) protein 25 in mammalian signaling transduction and flagellogenesis

Asian Journal of Andrology, 2022
Cilium, an organelle with a unique proteome and organization, protruding from the cell surface, generally serves as a force generator and signaling compartment. During ciliogenesis, ciliary proteins are synthesized in cytoplasm and transported into cilia
Yong-Hong Man, Isabella Warmbrunn, Ling Zhang, Zhi-Bing Zhang   +3 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Characterization of mouse IFT complex B [PDF]

Cell Motility, 2009
AbstractThe primary cilium plays a key role in the development of mammals and in the maintenance of health. Primary cilia are assembled and maintained by the process of intraflagellar transport (IFT). In this work, we characterize mouse IFT complex B by identifying all of the mammalian orthologues of complex B and B‐associated proteins previously ...
Follit, John A., Xu, Fenghui, Keady, Brian T., Pazour, Gregory J.   +3 more
openaire   +3 more sources

Ultrasonic Rainbow: A Meta‐Transducer for Frequency‐Selective Elastic Wave Control via Dithering‐Based Wavenumber Tuning

Advanced Intelligent Systems, EarlyView.
A piezoelectric meta‐transducer generates an ultrasonic rainbow, steering guided elastic waves to different angles according to frequency. A dithering‐based binary electrode design enables a closer realization of the target wavenumber filter, improving directional purity and suppressing unwanted lobes. Numerical and experimental validation demonstrates
Masoud Mohammadgholiha, Jochen Moll, Kilian Tschöke, Carsten Kruska, Sylvia E. Gebhardt, Luca De Marchi   +5 more
wiley   +1 more source

Synergistic Effect on Enhanced Oil Recovery in High Salinity Carbonate Reservoirs Using a Novel PEI‐Functionalized Carbon Nanotube Nanocomposite

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Enhancing oil recovery (EOR) in mature reservoirs is hindered by high interfacial tension (IFT) and oil‐wet rock formations, especially under harsh, high‐salinity conditions. This study aims to overcome these limitations by synthesizing a novel carbon nanotube nanocomposite covalently grafted with polyethylenimine and non‐covalently ...
Mohamed Abu Shuheil, Dilipkumar S. Patel, N. Beemkumar, Tariq Abdulkader Alrihaim, Dhirendra Nath Thatoi, Ripendeep Singh, Rohit Kumar, Parminder Singh, Ahmad Khalid   +8 more
wiley   +1 more source