Anti-IgE therapy for IgE-mediated allergic diseases: from neutralizing IgE antibodies to eliminating IgE+ B cells [PDF]
Clinical and Translational Allergy, 2018 Allergic diseases are inflammatory disorders that involve many types of cells and factors, including allergens, immunoglobulin (Ig)E, mast cells, basophils, cytokines and soluble mediators.
Jiayun Hu +5 more
semanticscholar +4 more sources
Regulation of B cell fate by chronic activity of the IgE B cell receptor [PDF]
eLife, 2016 IgE can trigger potent allergic responses, yet the mechanisms regulating IgE production are poorly understood. Here we reveal that IgE+ B cells are constrained by chronic activity of the IgE B cell receptor (BCR).
Zhiyong Yang +6 more
semanticscholar +3 more sources
Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response [PDF]
Nature Immunology, 2018 IgE is an ancient and conserved immunoglobulin isotype with potent immunological function. Nevertheless, the regulation of IgE responses remains an enigma, and evidence of a role for IgE in host defense is limited. Here we report that topical exposure to
Greg Crawford +15 more
semanticscholar +7 more sources
Gut microbiota composition and butyrate production in children affected by non-IgE-mediated cow’s milk allergy [PDF]
Scientific Reports, 2018 Cow’s milk allergy (CMA) is one of the earliest and most common food allergy and can be elicited by both IgE- or non-IgE-mediated mechanism. We previously described dysbiosis in children with IgE-mediated CMA and the effect of dietary treatment with ...
R. Berni Canani +11 more
semanticscholar +5 more sources
Geodetic point surface mass balances: a new approach to determine point surface mass balances on glaciers from remote sensing measurements [PDF]
The Cryosphere, 2021 Mass balance observations are very useful to assess climate change in different regions of the world. As opposed to glacier-wide mass balances which are influenced by the dynamic response of each glacier, point mass balances provide a direct climatic ...
C. Vincent +16 more
doaj +1 more source
A high-frequency, long-term data set of hydrology and sediment yield: the alpine badland catchments of Draix-Bléone Observatory [PDF]
Earth System Science Data, 2023 Draix-Bléone critical zone observatory was created in 1983 to study erosion processes in a mountainous badland region of the French Southern Alps. Six catchments of varying size (0.001 to 22 km2) and vegetation cover are equipped to measure water and ...
S. Klotz +12 more
doaj +1 more source
EAACI guidelines on the diagnosis of IgE‐mediated food allergy
Allergy. European Journal of Allergy and Clinical Immunology, 2023 This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach.
Alexandra F. Santos +62 more
semanticscholar +1 more source
Strong changes in englacial temperatures despite insignificant changes in ice thickness at Dôme du Goûter glacier (Mont Blanc area) [PDF]
The Cryosphere, 2020 The response of very-high-elevation glaciated areas on Mont Blanc to climate change has been analysed using observations and numerical modelling over the last 2 decades. Unlike the changes at low elevations, we observe very low glacier thickness changes,
C. Vincent +9 more
doaj +1 more source
The role of allergen‐specific IgE, IgG and IgA in allergic disease
Allergy. European Journal of Allergy and Clinical Immunology, 2021 Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease affecting more than 30% of the population. Exposure to even minute quantities of allergens can lead to the production of IgE antibodies in atopic individuals.
M. Shamji +6 more
semanticscholar +1 more source
Total IgE as a Marker for Chronic Spontaneous Urticaria
Allergy Asthma and Immunology Research, 2021 Objective Immunoglobulin E (IgE) and its receptor, FcɛRI, importantly contribute to the pathophysiology of chronic spontaneous urticaria (CSU). Recent findings point to a possible role of total IgE as a marker of CSU disease activity, endotypes, and ...
S. Altrichter +12 more
semanticscholar +1 more source