Results 41 to 50 of about 24,369,820 (336)

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

Aging Cell, 2019
The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia, is the result of many factors including an imbalance between protein synthesis and degradation, changes in metabolic/hormonal status, and in circulating levels ...
Francesca Ascenzi, L. Barberi, G. Dobrowolny, Aline Villa Nova Bacurau, C. Nicoletti, E. Rizzuto, N. Rosenthal, B. M. Scicchitano, A. Musarò   +8 more
semanticscholar   +1 more source

IGF-1 facilitates extinction of conditioned fear [PDF]

eLife, 2020
SUMMARYInsulin-like growth factor-1 (IGF-1) plays a key role in synaptic plasticity, degenerative diseases, spatial learning, and anxiety-like behavioral processes. While IGF-1 regulates neuronal activity in many areas of the brain, its effect on synaptic plasticity and animal behavior dependent on the prefrontal cortex remain unexplored. Here, we show
Laura E Maglio, José A Noriega-Prieto, Irene B Maroto, Jesús Martin-Cortecero, Antonio Muñoz-Callejas, Marta Callejo-Móstoles, David Fernández de Sevilla   +6 more
openaire   +5 more sources

Administration of bovine anti-IGF-1 immunoglobulin to dietary protein deficient rats alters dietary intake and plasma IGF-1 binding profiles, but does not affect change in body mass

Animal, 2010
The potential of antibodies raised against insulin-like growth factor-1 (IGF-1) as a treatment to enhance the anabolic actions of IGF-1 has been demonstrated in both rodent and ruminant models. We investigated whether treatment of genetically normal rats
N.N. Smith, M.J. Kelly, J.M. Pell, R.A. Hill   +3 more
doaj   +1 more source

IGF-1 receptor antagonism inhibits autophagy [PDF]

Human Molecular Genetics, 2013
Inhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target. This pathway is upstream of mTORC1, a negative regulator of autophagy.
Renna, Maurizio, Bento, Carla F., Fleming, Angeleen, Menzies, Fiona M., Siddiqi, Farah H., Ravikumar, Brinda, Puri, Claudia, Garcia-Arencibia, Moises, Sadiq, Oana, Corrochano, Silvia, Carter, Sarah, Brown, Steve D. M., Acevedo-Arozena, Abraham, Rubinsztein, David C.   +13 more
openaire   +5 more sources

IGF-1 and Survival in ESRD [PDF]

Clinical Journal of the American Society of Nephrology, 2014
Summary Background and objectives IGF-1 deficiency links to malnutrition in CKD patients; however, it is not clear to what extent it associates with survival among these patients. Design, setting, participants, & measurements Serum IGF-1 and other biochemical, clinical
Ting, Jia, Thiane, Gama Axelsson, Olof, Heimbürger, Peter, Bárány, Bengt, Lindholm, Peter, Stenvinkel, Abdul Rashid, Qureshi   +6 more
openaire   +2 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

IGF-1, oxidative stress and atheroprotection [PDF]

Trends in Endocrinology & Metabolism, 2010
Atherosclerosis is a chronic inflammatory disease in which early endothelial dysfunction and subintimal modified lipoprotein deposition progress to complex, advanced lesions that are predisposed to erosion, rupture and thrombosis. Oxidative stress plays a crucial role not only in initial lesion formation but also in lesion progression and ...
Yusuke, Higashi, Sergiy, Sukhanov, Asif, Anwar, Shaw-Yung, Shai, Patrice, Delafontaine   +4 more
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17. [PDF]

PLoS ONE, 2012
Insulin-like growth factor-1 receptor (IGF-1R) comprises two subunits, including a ligand binding domain on extra- cellular IGF-1Rα and a tyrosine phosphorylation site located on IGF-1Rβ.
Neil Hoa, Shanli Tsui, Nikoo F Afifiyan, Amiya Sinha Hikim, Bin Li, Raymond S Douglas, Terry J Smith   +6 more
doaj   +1 more source

Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

Nature Communications, 2018
Diminished growth factor signaling improves longevity in laboratory models, while a reduction in the somatotropic axis is favorably linked to human aging and longevity. Given the conserved role of this pathway on lifespan, therapeutic strategies, such as
Kai Mao, Gabriela Farias Quipildor, T. Tabrizian, Ardijana Novaj, F. Guan, Ryan O. Walters, F. Delahaye, G. Hubbard, Y. Ikeno, K. Ejima, Peng Li, D. Allison, H. Salimi-Moosavi, P. Beltran, P. Cohen, N. Barzilai, D. Huffman   +16 more
semanticscholar   +1 more source