Results 221 to 230 of about 101,358 (257)

Insulin receptor structure and its implications for the IGF-1 receptor

Current Opinion in Structural Biology, 2007
The insulin receptor (isoforms IR-A and IR-B) and the type-I insulin-like growth factor receptor (IGF-1R) are homologous, multi-domain tyrosine kinases that bind insulin and IGF-1 with differing specificity. IR is involved in metabolic regulation and IGF-1R in normal growth and development.
Michael C, Lawrence, Neil M, McKern, Colin W, Ward   +2 more
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Customizing The Targeting of IGF-1 Receptor

Future Oncology, 2009
The type 1 IGF receptor (IGF-IR) is activated by two ligands, IGF-1 and IGF-2, and by insulin at supraphysiological concentrations. It plays a significant role in the growth of normal and abnormal cells, and antibodies against the IGF-IR are now in clinical trials.
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The IGF-1-IGF-1 Receptor System Modulates Myocyte Proliferation but Not Myocyte Cellular Hypertrophy in Vitro

Experimental Cell Research, 1994
In preliminary experiments it was established that the hypertrophic and hyperplastic responses of neonatal cardiac myocytes in culture were associated with enhanced expression of IGF-1 and IGF-1 receptors in these cells. Therefore, to determine the role of IGF-1 receptors on myocyte growth, cells were exposed to antisense oligodeoxynucleotides to IGF-1
J, Kajstura, W, Cheng, K, Reiss, P, Anversa   +3 more
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IGF-1-dependent subunit communication of the IGF-1 holoreceptor: interactions between .alpha..beta. heterodimeric receptor halves

Biochemistry, 1989
Examination of 125I-IGF-1 affinity cross-linking and beta-subunit autophosphorylation has indicated that IGF-1 induces a covalent association of isolated alpha beta heterodimeric IGF-1 receptors into an alpha 2 beta 2 heterotetrameric state, in a similar manner to that observed for the insulin receptor [Morrison, B.D., Swanson, M.L., Sweet, L.J ...
P A, Wilden, J L, Treadway, B D, Morrison, J E, Pessin   +3 more
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Targeting the IGF-1 receptor: from rags to riches

European Journal of Cancer, 2004
The existence of the type 1 insulin-like growth factor receptor (IGF-IR) had been surmised for a number of years, before it was cloned in 1986 by Ullrich et al. [1]. At that time, the IGF-IR was considered a poor relative of the insulin receptor (IR), with which it has a 70% homology [1], a sort of redundant receptor that the cells used when the IR was
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Tyrosine kinase activity of brain insulin and IGF-1 receptors

Biochemical and Biophysical Research Communications, 1986
Lectin-purified rat brain preparations demonstrate specific [125I]insulin and [125I]-IGF-1 binding. Insulin-stimulable tyrosine kinase activity as measured by exogenous substrate phosphorylation was present in brain and liver lectin purified preparations with the delta kinase activity/B/F of brain approximately 2.5 fold greater than that of liver ...
W L, Lowe, D, LeRoith
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Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

Biochemical and Biophysical Research Communications, 2009
Recent studies have shown a direct association between IGF-1R and FAK, two important mediators of cell growth, survival and migration. However, the mechanism by which FAK affects IGF-1R function remains unknown. This study investigates the potential role of FAK in mediating activation and stability of IGF-1R.
Sandra, Andersson, Pádraig, D'Arcy, Olle, Larsson, Bita, Sehat   +3 more
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Insulin and IGF‐1 receptors contain covalently bound palmitic acid

Journal of Cellular Biochemistry, 1988
AbstractWe have studied the biosynthesis of the insulin receptor in a human hepatoma cell line, HepG2. As previously reported, these cells synthesize a disulphide–bonded α2 β2 tetrameric insulin receptor. Labelling of HepG2 cells with [3H]palmitate or [3H]myristate followed by immunoprecipitation with a polyclonal antireceptor antibody revealed the ...
A I, Magee, K, Siddle
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Endothelial IGF-1 Receptor Signalling in Diabetes and Insulin Resistance

Trends in Endocrinology & Metabolism, 2016
Despite contemporary medical therapy, people with diabetes and insulin resistance experience substantially increased risk of cardiovascular events caused by atherosclerosis. Dysfunction of the endothelium is a key phase in early atherogenesis and represents a promising therapeutic target.
Richard M. Cubbon, Mark T. Kearney, Stephen B. Wheatcroft   +2 more
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An Arrestin Role at the IGF-1 Receptor

Science's STKE, 2004
Povsic et al. investigated the role of β-arrestins in the activation of phosphatidylinositol 3-kinase (PI3K) by insulin-like growth factor 1 (IGF-1) and discovered that, unexpectedly, this involved a mechanism independent of the tyrosine kinase activity of the IGF-1 receptor.
openaire   +1 more source