Results 221 to 230 of about 30,609,190 (316)

8008 Insulin-like Growth Factor-1 (IGF-1) Level Fluctuations and Patient Reported Outcomes (PROMS) During Treatment with Long-acting Somatostatin Receptor Ligands (SRLs) for Acromegaly: a Prospective Study [PDF]

Ilan Remba-Shapiro, Júnia Ribeiro de Oliveira Longo Schweizer, Karen J. P. Liebert, Katharina Schilbach, Michelle M. Adams, Nicholas A. Tritos, Martin Bidlingmaier, Lisa B. Nachtigall   +7 more
openalex   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

High Dose of Hibiscus sabdariffa L. Extract Affects Fetal Weight and Placental IGF-1 Receptor Expression in Feed-Restricted Maternal Wistar Rats

Neng Tine Kartinah, Suhartika, Dewi Sukmawati, Erni Hernawati Purwaningsih   +3 more
openalex   +2 more sources

Basalt Fiber Surface Modification for Improved Interaction With Polyamide‐6 for High‐Performance Automotive Applications

Polymer Composites, EarlyView.
Amino‐silane treatment improves the basalt fiber–PA6 interface, enhancing composite performance. ABSTRACT Basalt fiber‐reinforced polymer (BFRP) composites have emerged as sustainable alternatives to glass fiber (GF) composites, but their performance is often controlled by the quality of the fiber–matrix adhesion.
Mohammad Mezbah Ul Hoque, Manuel Garcia‐Perez, Manuel Raul Pelaez‐Samaniego, Vikram Yadama   +3 more
wiley   +1 more source

Age-Related Changes in Testicular Insulin-Like Growth Factor-1 Receptor (IGF-1R) Distribution and Its Relationship with Biochemical Parameters in Broilers

R. Abdulameer Aaber, A. Louei Monfared, H. Sharoot   +2 more
openalex   +1 more source

Molecular Interactions of Viral Insulin/IGF‐Like Peptides With Zebrafish Receptors

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Signaling through the insulin receptor (IR) and the type 1 insulin‐like growth factor receptor (IGF1R) is modulated by secreted hormones and growth factor ligands (e.g., insulin and insulin‐like growth factor 1, IGF1). Impaired signaling in these receptors often leads to diabetes and oncogenic diseases.
Lev Levintov, Harish Vashisth
wiley   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Protective Potentials of Natural Products Against Vascular Dementia: A Comprehensive Review of Experimental Studies

Phytotherapy Research, EarlyView.
ABSTRACT Vascular dementia (VaD), accounting for up to 20% of dementia cases globally, is primarily driven by chronic cerebral hypoperfusion (CCH), which leads to progressive cognitive impairment. Despite the increasing prevalence of VaD, effective treatments remain limited.
Jung‐Hoon Kim, Yongtaek Oh, Suin Cho
wiley   +1 more source

Discriminating Between Living and Dead Bacteria With a Field‐Effect Transistor Based on Nano‐Channels

Small, EarlyView.
Bacterial viability is determined in a complex environment with a field‐effect biological transistor with a limit of detection of a single bacterium. Living, antibiotic‐treated, thermally denatured, and inhibited E. coli generate distinct electrical signatures, enabling label‐free single‐cell detection and providing new opportunities for rapid ...
Bar Chen, Vijay Garika, Shubham Babbar, Pooja Verma, Tom Cohen, Kfir Kattav, Fanny Akselrod, Aparnaa Shree Vijaikumar, Shankar Bhattarai, Sherina Harilal, Evgeny Pikhay, Inna Shechter, Doron Greental, Muhammad Y. Bashouti, Izhar Ron, Yakov Roizin, Barak Akabayov, Gil Shalev   +17 more
wiley   +1 more source