Results 81 to 90 of about 17,525 (157)

Local Anesthetics in Cancer: Mechanisms and Translational Perspectives

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang, Tu Huang, Yi‐hang Hao, Min Zheng, Xin‐hua Liang   +4 more
wiley   +1 more source

Insulin‐Like Growth Factor 1 Receptor Expression for Predicting PD‑1/PD‑L1 Inhibitor Response in Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology-Head and Neck Surgery
Objectives Insulin‐like growth factor 1 receptor (IGF‐1R) is crucial for immunological control and the development of different types of cancer. It is still uncertain how the expression of IGF‐1R impacts hypopharyngeal squamous cell carcinoma (HPSCC) and
Wen‐Jing Li, Xiao‐Lin Xu, Li‐Cheng Xu, Shun‐Peng Wang, Yao‐Yao Dong, Yi Wang, Xiao‐Li Ren, Lei Ye, Peng‐Yan Liu, Ming Liu, Lin‐Li Tian   +10 more
doaj   +1 more source

Targeting the insulin-like growth factor-1 receptor in human cancer

Frontiers in Pharmacology, 2013
The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-tumor agents are being developed.
Alexandre eArcaro
doaj   +1 more source

Silencing of miR-223 expression inhibits the apoptosis of HO-induced cardiomyocytes by increasing the activity of the IGF-1R/PI3K/AKT pathway

European Journal of Inflammation, 2020
To study the: (1) function of micro (mi)R-223 on H 2 O 2 -induced H9C2 cells; (2) relationship between miR-223 and insulin-like growth factor 1 receptor (IGF-1R); and (3) role of miR-223 on the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT ...
Qianqian Zhou, Yufen Li, Tianjin Gu
doaj   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, Volume 28, Issue 3, Page 1622-1637, March 2026.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

TSHR/IGF-1R Cross-Talk, Not IGF-1R Stimulating Antibodies, Mediates Graves' Ophthalmopathy Pathogenesis [PDF]

Thyroid, 2017
Christine C, Krieger, Susanne, Neumann, Bernice, Marcus-Samuels, Marvin C, Gershengorn   +3 more
openaire   +2 more sources

The Role of PDGFR-β Activation in Acquired Resistance to IGF-1R Blockade in Preclinical Models of Rhabdomyosarcoma

Translational Oncology, 2016
To determine what alternative pathways may act as mechanisms of bypass resistance to type 1 insulin-like growth factor receptor (IGF-1R) blockade in rhabdomyosarcoma (RMS), we compared expression of receptor tyrosine kinase activity in a number of IGF-1R
Christine M. Heske, Choh Yeung, Arnulfo Mendoza, Joshua T. Baumgart, Leah D. Edessa, Xiaolin Wan, Lee J. Helman   +6 more
doaj   +1 more source

Insulin‐like growth factor‐1 receptor regulates repair of ultraviolet B‐induced DNA damage in human keratinocytes in vivo

Molecular Oncology, 2016
The activation status of the insulin‐like growth factor‐1 receptor (IGF‐1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo.
Mathew M. Loesch, Ann E. Collier, David H. Southern, Rachel E. Ward, Sunil S. Tholpady, Davina A. Lewis, Jeffrey B. Travers, Dan F. Spandau   +7 more
doaj   +1 more source

IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase+ Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia

Stem Cell Reports, 2018
Summary: Hypoxia cooperates with endocrine signaling to maintain the symmetric self-renewal proliferation and migration of embryonic germline stem cells (GSCs).
Yung-Che Kuo, Heng-Kien Au, Jue-Liang Hsu, Hsiao-Feng Wang, Chiung-Ju Lee, Syue-Wei Peng, Ssu-Chuan Lai, Yu-Chih Wu, Hong-Nerng Ho, Yen-Hua Huang   +9 more
doaj   +1 more source

Serum IGF-1, IGF-1R and BDNF levels in GDM pregnant women and neonatal umbilical cord blood and their relationship with neonatal brain injury

Zhongguo linchuang yanjiu
Objective To investigate the serum levels of insulin-like growth factor 1 (IGF-1), IGF-1 receptor (IGF-1R), and brain-derived neurotrophic factor (BDNF) in pregnant women with gestational diabetes mellitus (GDM) and neonatal umbilical cord blood, and ...
SONG Yuanli*, SHAO Fang, XUE Juan
doaj   +1 more source