Results 81 to 90 of about 19,264 (196)
Chinese Journal of Lung Cancer, 2012 Background and objective It has been proven that the insulin-like growth factor 1 receptor (IGF-1R) gene is an important regulator of many aspects of growth, differentiation, and development.
Yusheng CHEN +4 more
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Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers
Biomedical Papers, 2020 Background: The rising incidence of thyroid cancer observed in the last few decades requires an improvement in diagnostic tools and management techniques for patients with thyroid nodules. Aims: The aim of this study was to assess serum concentrations of
Hanna Lawnicka +7 more
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Food Science &Nutrition, Volume 14, Issue 1, January 2026.The modified calycosin derivative H10 was more effective in inhibiting cell proliferation through G0/G1 cell cycle arrest, together with inhibiting the migration and colony formation abilities of ovarian cancer cell lines SKOV3 and A2780. Comparative proteomic analysis coupled with Ingenuity Pathway Analysis further delineated calycosin derivative H10 ...
Fuhong Yang +8 more
wiley +1 more source
Targeting the insulin-like growth factor-1 receptor in human cancer
Frontiers in Pharmacology, 2013 The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-tumor agents are being developed.
Alexandre eArcaro
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European Journal of Inflammation, 2020 To study the: (1) function of micro (mi)R-223 on H 2 O 2 -induced H9C2 cells; (2) relationship between miR-223 and insulin-like growth factor 1 receptor (IGF-1R); and (3) role of miR-223 on the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT ...
Qianqian Zhou, Yufen Li, Tianjin Gu
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Astrocytic Igfbp2 Promotes Spontaneous Seizures in a Mouse Model of Mesial Temporal Lobe Epilepsy
Glia, Volume 74, Issue 1, January 2026.Igfbp2 is upregulated in hippocampal astrocytes of MTLE model mice. Igfbp2 enhances dentate granule cell excitability. Astrocytic Igfbp2 deletion reduces spontaneous seizures. ABSTRACT Mesial temporal lobe epilepsy (MTLE) is a common, frequently drug‐resistant epilepsy characterized by seizures arising from the hippocampus.
Shinichi Kinoshita +4 more
wiley +1 more source
Translational Oncology, 2016 To determine what alternative pathways may act as mechanisms of bypass resistance to type 1 insulin-like growth factor receptor (IGF-1R) blockade in rhabdomyosarcoma (RMS), we compared expression of receptor tyrosine kinase activity in a number of IGF-1R
Christine M. Heske +6 more
doaj +1 more source
Extracellular Prolidase (PEPD) Induces Anabolic Processes through EGFR, β1-integrin, and IGF-1R Signaling Pathways in an Experimental Model of Wounded Fibroblasts [PDF]
, 2021 Weronika Baszanowska +4 more
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Molecular Oncology, 2016 The activation status of the insulin‐like growth factor‐1 receptor (IGF‐1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo.
Mathew M. Loesch +7 more
doaj +1 more source
Stem Cell Reports, 2018 Summary: Hypoxia cooperates with endocrine signaling to maintain the symmetric self-renewal proliferation and migration of embryonic germline stem cells (GSCs).
Yung-Che Kuo +9 more
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