Results 91 to 100 of about 14,093,235 (401)

Transcriptional regulation of the IGF signaling pathway by amino acids and insulin-like growth factors during myogenesis in Atlantic salmon. [PDF]

PLoS ONE, 2010
The insulin-like growth factor signalling pathway is an important regulator of skeletal muscle growth. We examined the mRNA expression of components of the insulin-like growth factor (IGF) signalling pathway as well as Fibroblast Growth Factor 2 (FGF2 ...
Neil I Bower, Ian A Johnston
doaj   +1 more source

Insulin Resistance and the IGF-I-Cortical Bone Relationship in Children Ages 9-13 Years [PDF]

, 2017
IGF-I is a pivotal hormone in pediatric musculoskeletal development. Although recent data suggest that the role of IGF-I in total body lean mass and total body bone mass accrual may be compromised in children with insulin resistance, cortical bone ...
Ding, Ke-Hong, Gallant, Kathleen M. Hill, Hamrick, Mark W., Hausman, Dorothy B., Isales, Carlos M., Jenkins, Nathan T., Kindler, Joseph M., Laing, Emma M., Lewis, Richard D., Martin, Berdine R., McCabe, George P., Oshri, Assaf, Peacock, Munro, Pollock, Norman K., Warden, Stuart J., Weaver, Connie M.   +15 more
core   +1 more source

RUNX2 Activation in Fibro/Adipogenic Progenitors Promotes Muscle Fibrosis in Muscular Dystrophy

Advanced Science, EarlyView.
This study revealed a novel role of the chemokine‐TGF‐β1‐RUNX2 axis in determining the fate of FAP differentiation and modulating muscle fibrosis in patients and mice with muscular dystrophies. ABSTRACT Clinical evidence indicates concurrent muscle inflammation and fibrosis in muscular dystrophies (MDs); however, the molecular mechanisms underlying ...
Pengkai Wu, Zehua Zhang, Kai Zheng, Ziqi Zhu, Yong Zhu, Abdukahar Kiram, Lei Zhao, Huihui Chen, Zhu Xu, Xihua Li, Beicheng Sun, Zhijian Li, Dengqiu Xu   +12 more
wiley   +1 more source

Revisiting the Role of Insulin-Like Growth Factor-I Receptor Stimulating Activity and the Apolipoprotein E in Alzheimer’s Disease

Frontiers in Aging Neuroscience, 2019
Background: Alterations in insulin-like growth factor I (IGF-I) signaling have been associated with dementia and Alzheimer’s disease (AD). Studies on the association between IGF-I levels and dementia risk have been inconclusive.
Sara A. Galle, Sara A. Galle, Ashley van der Spek, Madeleine L. Drent, Madeleine L. Drent, Michael P. Brugts, Erik J. A. Scherder, Joseph A. M. J. L. Janssen, M. Arfan Ikram, M. Arfan Ikram, M. Arfan Ikram, Cornelia M. van Duijn, Cornelia M. van Duijn   +12 more
doaj   +1 more source

Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2015
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response
Min Sun Kim, Dae-Yeol Lee
doaj   +1 more source

Conformable Device for Independent Measurements of Mucosal and Vascular Barriers in a Complex In Vitro Intestinal Model

Advanced Science, EarlyView.
Development of more complex in vitro models necessitates the development of improved monitoring approaches. This work demonstrates a novel conformable device capable of measuring the resistance of two cell barriers within a single model independently, a significant advantage over conventional trans‐epithelial/endothelial electrical resistance (TEER ...
Alexandra Elisabeth Wheeler, Sonja Blasche, Rob Bradley, Rachana Acharya, Sophie Oldroyd, David Bulmer, Kiran R. Patil, Róisín Meabh Owens   +7 more
wiley   +1 more source

Hepatic mRNA expression and plasma levels of insulin-like growth factor-I (IGF-I) in broiler chickens selected for different growth rates

Genetics and Molecular Biology, 2004
The hepatic expression and plasma concentrations of IGF-I were investigated in three broiler chicken strains selected for different growth rates (HP-Hubbard-Pettersen, a fast growing strain; NN-Naked-neck, a strain with an intermediate growth rate and a ...
Poliana Fernanda Giachetto, Eduardo Correa Riedel, Jane Eyre Gabriel, Maria Inês Tiraboschi Ferro, Sônia Marli Zingaretti Di Mauro, Marcos Macari, Jesus Aparecido Ferro   +6 more
doaj   +1 more source

The role of IGF-I in the development of cardiovascular disease in type 2 diabetes mellitus: is prevention possible? [PDF]

, 2002
The incidence of peripheral, cerebro- and cardiovascular disease (CVD) in patients with type 2 diabetes mellitus is approximately twice as high as in the non-diabetic population.
Janssen, J.A.M.J.L. (Joop), Lamberts, S.W.J. (Steven)   +1 more
core   +2 more sources

Biohybrid Tendons Enhance the Power‐to‐Weight Ratio and Modularity of Muscle‐Powered Robots

Advanced Science, EarlyView.
Biohybrid robots powered by skeletal muscle actuators are capable of dynamically adapting to environmental cues. This study takes inspiration from native muscle–tendon architecture by leveraging tough hydrogels as synthetic tendons for muscle actuators to enhance the power‐to‐weight ratio and modularity of biohybrid machines.
Nicolas Castro, Ronald Heisser, Maheera Bawa, Bastien Aymon, Sarah Wu, Annika Marschner, Sonika Kohli, Angel Bu, Laura Rosado, Martin Culpepper, Xuanhe Zhao, Ritu Raman   +11 more
wiley   +1 more source

The effect of epidermal growth factor and IGF-I infusion on hepatic and renal expression of the IGF-system in adult female rats [PDF]

, 2000
Systemic administration of epidermal growth factor (EGF) in neonatal rats results in reduced body weight gain and decreased circulating levels of IGF-I, suggesting its involvement in EGF-induced growth retardation.
Berghout, E.M., Cingel-Ristic, V., Dits, N.F. (Natasja), Drop, S.L.S. (Stenvert), Flyvbjerg, A. (Allan), Groffen, C.A.H. (Cora), Neck, J.W. (Han) van, Vinter-Jensen, L.   +7 more
core   +1 more source