Results 311 to 320 of about 152,806 (342)
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Localization of IGF-I and IGF-I Receptor mRNA inSparus aurataLarvae
General and Comparative Endocrinology, 1997Studies of the ontogeny of IGF-I mRNA during embryonic and larval development of the gilthead sea bream Sparus aurata showed its expression during these early developmental stages. The present study applies in situ hybridization to localize IGF-I and IGF receptor mRNAs in 16-day larvae of S. aurata. Paraffin sections were hybridized with homologous RNA
Bruria Funkenstein +2 more
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The IGF-I/IGF-I Receptor Pathway: Implications in the Pathophysiology of Thyroid Cancer
Current Medicinal Chemistry, 2005The biological actions of the insulin-like growth factor(IGF)-I are mediated by its activation of the IGF-I receptor (IGF-I R), a transmembrane tyrosine kinase linked to the Akt and ras-raf-MAPK cascades. A functional IGF-I R is required for the cell to progress through the cell cycle. Most importantly, cells lacking this receptor cannot be transformed
CIAMPOLILLO A +2 more
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Molecular and Cellular Endocrinology, 1994
Limited information is available concerning the molecular and cellular mechanisms that regulate expression of insulin-like growth factor-I (IGF-I) binding proteins (IGFBPs) in bovine mammary epithelial cells. Here, we report on the autocrine mechanisms of action of IGF-I and hormonal regulation of expression of IGFBPs in bovine mammary epithelial MD ...
R. Michael Akers +4 more
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Limited information is available concerning the molecular and cellular mechanisms that regulate expression of insulin-like growth factor-I (IGF-I) binding proteins (IGFBPs) in bovine mammary epithelial cells. Here, we report on the autocrine mechanisms of action of IGF-I and hormonal regulation of expression of IGFBPs in bovine mammary epithelial MD ...
R. Michael Akers +4 more
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The IGF-I Axis in Thyroid Carcinoma
Current Pharmaceutical Design, 2007Insulin like-growth factor I (IGF-I) has been involved in the pathogenesis of a variety of human neoplasia due to the mitogenic and anti-apoptotic properties of its cognate receptor. In human thyroid carcinomas, we have previously documented an increased immunoreactivity of both IGF-I and the IGF-I receptor (IGF-I R) associated with up regulation of ...
Ciampolillo A +3 more
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Acta Endocrinologica, 1987
Abstract. Binding of 125I-insulin-like growth factor-I and 125I-ovine somatomedin-C/IGF-I to monolayer cultures of muscle-derived ovine fibroblasts is described. Preliminary competitive binding experiments indicate that ovine fibroblasts possess independent cell surface receptors for IGF-I.
B. A. Mathison +2 more
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Abstract. Binding of 125I-insulin-like growth factor-I and 125I-ovine somatomedin-C/IGF-I to monolayer cultures of muscle-derived ovine fibroblasts is described. Preliminary competitive binding experiments indicate that ovine fibroblasts possess independent cell surface receptors for IGF-I.
B. A. Mathison +2 more
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Hormone Research, 2006
• The IGF system is the major mediator of both intra-uterine and postnatal growth. • The IGF-I receptor appears to mediate the growth-promoting effects of both IGF-I and IGF-II. • The role of IGF binding proteins in mediating the growth-promoting actions of the IGFs is complex and remains incompletely understood.
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• The IGF system is the major mediator of both intra-uterine and postnatal growth. • The IGF-I receptor appears to mediate the growth-promoting effects of both IGF-I and IGF-II. • The role of IGF binding proteins in mediating the growth-promoting actions of the IGFs is complex and remains incompletely understood.
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Distribution of IGF-I mRNA and IGF-I binding sites in the rat kidney
Histochemistry, 1992In the present study we have investigated the distribution of IGF-I mRNA and IGF-I binding sites in the rat kidney. The distribution of IGF-I mRNA was investigated using a simple and sensitive non-radioactive in situ hybridisation technique based on probe labelling with digoxigenin labelled-UTP followed by detection with conventional immunocytochemical
P. S. Eriksson +3 more
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Growth Hormone & IGF Research, 2008
To determine whether different albumins have an effect on IGF-I binding assays.We have studied the effect of five different albumins in plate antibody capture binding assay. For IGF-IR studies the IGF-IR specific antibody 24-31 was used and for IR/IGF-IR hybrid receptors the IR specific antibody 83-7 was used.
Asser Sloth Andersen +2 more
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To determine whether different albumins have an effect on IGF-I binding assays.We have studied the effect of five different albumins in plate antibody capture binding assay. For IGF-IR studies the IGF-IR specific antibody 24-31 was used and for IR/IGF-IR hybrid receptors the IR specific antibody 83-7 was used.
Asser Sloth Andersen +2 more
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2018
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are relevant regulators of bone homeostasis throughout human life, acting on both the trabecular and cortical bone [1]. The anabolic effects of these hormones are important to reach an adequate bone mass during puberty and early adulthood—a critical determinant for the future risk of ...
Frara, Stefano +5 more
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Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are relevant regulators of bone homeostasis throughout human life, acting on both the trabecular and cortical bone [1]. The anabolic effects of these hormones are important to reach an adequate bone mass during puberty and early adulthood—a critical determinant for the future risk of ...
Frara, Stefano +5 more
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Molecular Reproduction and Development, 1993
AbstractConstitutive overexpression of the insulin‐like growth factor‐I (IGF‐I) receptor makes 3T3 cells capable of growing in serum‐free medium supplemented solely with IGF‐I to the total exclusion of the platelet‐derived growth factor (PDGF) and epidermal growth factor (EGF) receptors, the other two receptors that are required for the growth of 3T3 ...
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AbstractConstitutive overexpression of the insulin‐like growth factor‐I (IGF‐I) receptor makes 3T3 cells capable of growing in serum‐free medium supplemented solely with IGF‐I to the total exclusion of the platelet‐derived growth factor (PDGF) and epidermal growth factor (EGF) receptors, the other two receptors that are required for the growth of 3T3 ...
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