Results 321 to 330 of about 152,806 (342)

Patient Selection for IGF-I Therapy

Hormone Research, 2006
• Many patients previously classified as 'idiopathic short stature' have Primary IGFD. In some studies, this number is as high as 50%. • For patients with severe Primary IGFD, treatment of choice should be IGF-I, either alone or in combination with IGFBP-3.
Clayton, P. E., Ayoola, O., Whatmore, A. J.   +2 more
openaire   +4 more sources

Role of GH and IGF-I in the regulation of IGF-I, IGF-I receptor and IGF binding protein gene expression in the rat spleen

Regulatory Peptides, 1994
To characterize the expression of the IGF-I system in the spleen and its role in spleen growth, we have studied the effect of hypophysectomy and the action of either GH or IGF-I treatment on the expression of several components of the IGF system in the rat.
Shoshana Yakar, Rina Meidan, Zila Shen-Orr, Derek LeRoith, Horacio M. Domené, Fernando Cassorla, Charles T. Roberts   +6 more
openaire   +3 more sources

Aged Human Thymus Hassall's Corpuscles Are Immunoreactive for IGF‐I and IGF‐I Receptor

The Anatomical Record, 2009
AbstractAlthough Hassall's corpuscles have been proposed to act in both maturation of developing thymocytes and removal of apoptotic cells, their function remains an enigma. The involvement of insulin‐like growth factor I (IGF‐I) in the local autocrine and paracrine control of T‐cell development in human thymus is still unclear.
Vili V. Pashev, Lyubomir D. Spassov, Tsvetana Ts-S. Marinova, Ralitsa S. Dzhupanova, Varban Ganev, Veselin I. Vlassov, Maya D. Markova, Doychin N. Angelov   +7 more
openaire   +3 more sources

Simulation of IGF-I pharmacokinetics after infusion of recombinant IGF-I in human subjects

American Journal of Physiology-Endocrinology and Metabolism, 1997
The pharmacokinetics of recombinant human insulin-like growth factor I (IGF-I) were studied in four healthy volunteers by a 3-h infusion at a rate of 20 micrograms.kg-1.h-1. A compartmental model was used to simulate the plasma “free” IGF-I and IGF-I associated with the 50- and 150-kDa plasma protein fractions.
M. A. Boroujerdi, Richard H. Jones, David Russell-Jones, Peter H. Sönksen   +3 more
openaire   +3 more sources

Expression of IGF-I and IGF-I Receptor Gene in the Corpus Luteum

1991
Insulin-like growth factors (IGFs) are peptide mitogens that have been implicated in growth and development of the rat ovary. Insulin-like growth factor I (IGF-I) has been shown to affect granulosa cell proliferation and differentiation in vitro (1).Recent investigations indicate that granulosa cells produce IGF-I and IGF-I binding proteins (2) and are
G. Gibori, T. G. Parmer, C. Albarracin, M. Zilberstein, I. Khan   +4 more
openaire   +2 more sources

Binding of IGF I and IGF I-stimulated phosphorylation in canine renal basolateral membranes

American Journal of Physiology-Endocrinology and Metabolism, 1986
To characterize the interaction of the renal proximal tubular cell with insulin like growth factor I (IGF I), we measured binding of 125I-IGF I to proximal tubular basolateral membranes from dog kidney and induced IGF I-stimulated phosphorylation of basolateral membranes.
M. R. Hammerman, J. R. Gavin
openaire   +3 more sources

IGF‐I binding and IGF‐I expression in regenerating muscle of normal and hypophysectomized rats

Acta Physiologica Scandinavica, 1992
Binding of iodinated IGF‐I to tissue sections from regenerating muscle was studied by autoradiography in normal and in hypophysectomized rats. Binding of IGF‐I was low in control muscle in both groups of animals, but increased transiently about 10‐fold during regeneration after injury.
E. Jennische, G. L. Matejka
openaire   +3 more sources

IGF-I and the endocrinology of aging

Current Opinion in Endocrine and Metabolic Research, 2019
Abstract Age is a major determinant of circulating Insulin-like Growth Factor-I (IGF-I) levels. In healthy populations levels of IGF-I markedly differ between individuals, but total IGF-I, IGFBP-3, and their ratio within one individual show only small changes with age over time.
openaire   +2 more sources

IGF-I Receptor Function [PDF]

, 1999
The insulin-like growth factor (IGF)-I receptor, or type 1 IGF receptor, is a transmembrane tyrosine kinase receptor that mediates the majority of the biological actions of IGF-I and IGF-II (1,2). The ligands, IGF-I or IGF-II, bind to the extracellular domain of the receptor and initiate a conformational change that is transmitted to the intracellular ...
Vicky A. Blakesley, Anatolii P. Koval, Yumiko Okubo, Derek LeRoith, Andrew A. Butler   +4 more
openaire   +1 more source

Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle cells

American Journal of Physiology-Endocrinology and Metabolism, 2006
Insulin and insulin-like growth factor I (IGF-I) are known to affect cardiovascular disease. We have investigated ligand binding and the dose-response relationship for insulin and IGF-I on vascular smooth muscle cells (VSMCs) at the receptor level.
G.S. Johansson, Hans J. Arnqvist
openaire   +3 more sources