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IGF-I in Human Growth: Lessons from Defects in the GH-IGF-I Axis
2013The IGF system plays a critical role in all phases of human growth, including intrauterine, childhood and pubertal. The importance of IGF-I for both in utero as well as postnatal human growth is highlighted by rare human homozygous IGF1 mutations, which are characterized by intrauterine growth retardation (IUGR), microcephaly, mental retardation and ...
Peng Fang +4 more
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Utility of Free IGF-I Measurements
Pituitary, 2007For nearly 30 years, the endogenous bioactivity of insulin-like growth factor I (IGF-I) has been estimated by its circulating concentrations of immunoreactive IGF-I, obtained after either removal or inactivation of the IGF-binding proteins (IGFBPs), and today serum/plasma total IGF-I serves as a useful parameter in the diagnosis and clinical control of
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Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins
1994Distinct domains of IGF-I are important for maintaining high affinity for the IGF-I receptor and for the various species of IGFBPs. The analogs that selectively bind the receptor have proven useful in determining the relative importance of IGFBPs in the regulation of the biological activity of IGF-I.
Marvin L. Bayne, Margaret A. Cascieri
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Expression of IGF-I and IGF-I Receptor Gene in Transformed Luteal Cells
1991We have recently demonstrated that the rat corpus luteum synthesizes both insulin-like growth factor I (IGF-I) and IGF-I receptor mRNAs (1). IGF-I is a mitogenic factor known for its stimulatory effect on cell proliferation (2). In certain cells and specifically rat granulosa cells, IGF-I also causes cellular differentiation and maturation.
T. G. Parmer +7 more
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The Role of the IGF-I Receptor in Apoptosis
1997Publisher Summary This chapter examines the role of the insulin-like growth factor-I receptor (IGF-IR) in apoptosis. As cellular proliferation and transformation are clearly related to apoptosis, the role of the IGF-IR in mitogenesis is examined and in transformation, and its role in apoptosis is also focused. The IGF-IR is a tyrosine kinase receptor
Mariana Resnicoff +3 more
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IGF-I and IGF-I receptor in mouse colon cancer cells
In Vitro Cellular & Developmental Biology - Animal, 1991Pomila Singh +3 more
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Immunocytochemical evidence for the presence of IGF‐I and IGF‐I receptors in human endocrine tumours
Acta Physiologica Scandinavica, 1992B. Wängberg +3 more
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