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Long-term clinical control in acromegaly patients with postoperative discordant nadir growth hormone during oral glucose tolerance test and insulin-like growth factor 1 levels: a retrospective observational study and literature review. [PDF]

Langenbecks Arch Surg
Ishida T, Kawaguchi T, Ogawa Y, Endo H.
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IGF-II receptors and IGF-II-stimulated glucose transport in human fat cells

American Journal of Physiology-Endocrinology and Metabolism, 1990
Insulin-like growth factor II (IGF-II) receptors have been described in rat but not in human adipocytes. In both species, IGF-II has been reported to stimulate glucose transport by interacting with the insulin receptor. In this study, we have unequivocally demonstrated the presence of IGF-II receptors in human adipocytes.
M K, Sinha, C, Buchanan, C, Raineri-Maldonado, P, Khazanie, S, Atkinson, R, DiMarchi, J F, Caro   +6 more
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Modulation of Cathepsin D Routing by IGF-II Involves IGF-II Binding to IGF-II/M6P Receptor in MCF-7 Breast Cancer Cells

Growth Factors, 2004
The IGF-II/M6P receptor targets cathepsin D to the lysosomes and it also binds IGF-II. Although the binding sites for IGF-II and cathepsin D are distinct, reciprocal interactions between the ligands have been observed. We have demonstrated that proIGF-II expression modulates routing of cathepsin D.
Jesika S, Faridi, Subburaman, Mohan, Daisy D, De León   +2 more
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High molecular weight forms of IGF-II ('big-IGF-II') released by Wilms' tumor cells

European Journal of Endocrinology, 1997
Insulin-like growth factor-II (IGF-II) is thought to play a critical role in the development of embryonic tumors such as Wilms' tumor. However, despite highly elevated IGF-II mRNA levels in tumors, IGF-II is not elevated in the serum of patients with Wilms' tumors. Recently high molecular weight forms of IGF-II ('big'- or pro-IGF-II) have been found to
S, Schmitt, Q, Ren-Qiu, T, Torresani, M, Doebeli, J, Zapf, E J, Schoenle   +5 more
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Antisense Oligodeoxynucleotides of IGF-II Selectively Inhibit Growth of Human Hepatoma Cells Overproducing IGF-II

Journal of Biochemistry, 1997
Insulin-like growth factor II (IGF-II) is expressed in many developing embryonic tissues and is involved in mammalian growth and development. After birth, serum IGF-II is mainly produced by liver cells. Many reports have indicated that IGF-II is overexpressed in some hepatocellular carcinoma (HCC) tissue. These findings imply the possible importance of
S B, Lin, S H, Hsieh, H L, Hsu, M Y, Lai, L S, Kan, L C, Au   +5 more
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Specific endonucleolytic cleavage of IGF-II mRNAs

Biochemical and Biophysical Research Communications, 1991
Expression of the human insulin-like growth factor II (IGF-II) gene gives rise to a family of mRNAs which are expressed in a tissue- and developmental-specific manner. Recently, an IGF-II RNA species of 1.8 kb was detected which consists of the 3' terminal untranslated region of the last IGF-II exon.
D, Meinsma, P E, Holthuizen, J L, Van den Brande, J S, Sussenbach   +3 more
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Involvement of IGF-II in human cancer

Journal of Endocrinology, 1996
IGF-II is a regulatory peptide which appears to be involved significantly in the progression of many tumors, while minimally involved in post-fetal non-tumor tissue. Interruption of IGF-II pathways therefore offers the possibility of tumor control with a high therapeutic index. Investigators should continue to evaluate tumors for the involvement of IGF-
J A, Toretsky, L J, Helman
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Interactions of pro-cathepsin D and IGF-II on the mannose-6-phosphate / IGF-II receptor

Breast Cancer Research and Treatment, 1992
The mannose-6-phosphate (Man-6P)/IGF-II receptor is a multifunctional receptor which binds with a high affinity on distinct sites two strikingly different classes of ligands: IGF-II, and Man-6P bearing molecules such as lysosomal enzymes or other biologically relevant ligands (TGF beta precursor, EGF receptor, proliferin...).
F, Vignon, H, Rochefort
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Synthesis of Insulin-Like Growth Factor II (IGF-II) in Fetal Rat Tissues: Translation of IGF-II Ribonucleic Acid and Processing of Pre-Pro-IGF-II*

Endocrinology, 1988
The single insulin-like growth factor II (IGF-II) gene is transcribed into multiple RNA species in most fetal and neonatal rat tissues. For IGF-II to serve as a local growth factor in fetal tissues, IGF-II RNA must be translated into pre-pro-rat (r) IGF-II, and the biosynthetic precursor processed to smaller biologically active forms.
J A, Romanus, Y W, Yang, S O, Adams, A N, Sofair, L Y, Tseng, S P, Nissley, M M, Rechler   +6 more
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