Results 141 to 150 of about 224,363 (192)
Some of the next articles are maybe not open access.
Hormone Research in Paediatrics, 2004
Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several animal models.
J A M J L, Janssen, S W J, Lamberts
openaire +2 more sources
Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several animal models.
J A M J L, Janssen, S W J, Lamberts
openaire +2 more sources
Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins
1994Distinct domains of IGF-I are important for maintaining high affinity for the IGF-I receptor and for the various species of IGFBPs. The analogs that selectively bind the receptor have proven useful in determining the relative importance of IGFBPs in the regulation of the biological activity of IGF-I.
M A, Cascieri, M L, Bayne
openaire +2 more sources
IGF, IGF receptor and overgrowth syndromes.
Pediatric endocrinology reviews : PER, 2006The insulin-like growth factors are a family of growth factors, binding proteins and receptors that are involved in normal growth as well as in a number of pathological states. Overgrowth syndromes are a group of disorders characterized by a phenotype of excessive somatic and visceral growth.
Itay, Bentov, Haim, Werner
openaire +1 more source
The role of IGFs in catabolism
Baillière's Clinical Endocrinology and Metabolism, 1997The hypercatabolic response to trauma, extensive surgery and sepsis is characterized by an increased metabolic rate, severe muscle wasting and a negative nitrogen balance. This process of 'autocannibalism' may be in part a consequence of a disordered growth hormone (GH)/insulin-like growth factor (IGF) axis. In this chapter the normal physiology of the
C, Botfield, R J, Ross, C J, Hinds
openaire +2 more sources
Hormone and Metabolic Research, 1994
The insulin-like growth factor (IGF) axis is a multi-component network of molecules involved in the regulation of cell growth. The axis includes two major ligands, (IGF-I and IGF-II), cell surface receptors, (the type I IGF receptor family as well as the type II IGF receptor), a family of high affinity binding proteins which regulate IGF availability ...
P, Cohen, D M, Peehl, R G, Rosenfeld
openaire +2 more sources
The insulin-like growth factor (IGF) axis is a multi-component network of molecules involved in the regulation of cell growth. The axis includes two major ligands, (IGF-I and IGF-II), cell surface receptors, (the type I IGF receptor family as well as the type II IGF receptor), a family of high affinity binding proteins which regulate IGF availability ...
P, Cohen, D M, Peehl, R G, Rosenfeld
openaire +2 more sources
IGFS and Muscle Differentiation
1994The Role of IGFs in Myogenesis. Thus we are now convinced that the control of myogenesis by IGFs is a general phenomenon that occurs in all skeletal muscle cells, whether or not IGFs are added to the "differentiation" medium. We believe that several medium components contribute to the suppression of IGF-II expression in myoblasts incubated in high ...
J R, Florini +3 more
openaire +2 more sources
Annales d'Endocrinologie, 2016
Firstly discovered as a placental protein present abundantly in the circulation of pregnant women, pregnancy-associated plasma protein-A (PAPP-A) is widely expressed in multiple tissues. PAPP-A is a metalloproteinase that is able to specifically cleave three insulin-like growth factor binding proteins (IGFBPs): IGFBP-2, -4 and -5.
Philippe, Monget, Claus, Oxvig
openaire +2 more sources
Firstly discovered as a placental protein present abundantly in the circulation of pregnant women, pregnancy-associated plasma protein-A (PAPP-A) is widely expressed in multiple tissues. PAPP-A is a metalloproteinase that is able to specifically cleave three insulin-like growth factor binding proteins (IGFBPs): IGFBP-2, -4 and -5.
Philippe, Monget, Claus, Oxvig
openaire +2 more sources
IGFs and their binding proteins
Nuclear Medicine and Biology, 1994Insulin-like growth factors (IGFs), initially known as somatomedins, and their specific, high-affinity binding proteins (IGFBPs) are synthesized in most tissues, but principally in the liver. The interest of measuring their circulating levels, which reflect liver production, is to obtain indications as to their endocrine function and regulation.
M, Gourmelen, L, Perin, Y, Le Bouc
openaire +2 more sources
The IGF family and folliculogenesis
Journal of Reproductive Immunology, 1998The process of ovarian follicular development is a long and arduous one, marked by dramatic proliferation and differentiation of both the somatic and germ cell elements. To a large extent, this explosive agenda is under the control of conventional endocrine principles, involving hormones such as pituitary gonadotropins and ovarian steroids. Importantly,
openaire +2 more sources
IGF-Independent Actions of the IGF Binding Proteins
1999The insulin-like growth factor binding proteins (IGFBPs) are members of the IGF signaling system, along with the ligands (insulin, IGF-I, and IGF-II) and a family of transmembrane receptors (the insulin, type 1 IGF and type 2 IGF receptors) (1–11). The human IGFBP superfamily consists of six high-affinity IGF binders (IGFBPs 1–6) and four low-affinity ...
Youngman Oh, Ron G. Rosenfeld
openaire +1 more source