Results 151 to 160 of about 224,363 (192)
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IGF Binding Proteins as Modulators of IGF Action
1999The insulin-like growth factors (IGFs) are able to modulate an extraordinarily wide variety of biological actions. First described as stimulators of proteoglycan biosynthesis in cartilage (1,2), IGF peptides (then known as somatomedins or nonsuppressible insulin-like activity) were soon recognized as having insulin-like stimulatory effects on the ...
Janet L. Martin, Robert C. Baxter
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Clinics in Laboratory Medicine, 2000
Serum IGF-I is controlled by several different regulatory factors. The final adult level represents the sum of the inert circulating depot, newly derived IGF-I synthesized from various tissues including liver, heart, kidney, bone, and others, and the departure from the circulation of IGF-I through mechanisms including receptor internalization and ...
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Serum IGF-I is controlled by several different regulatory factors. The final adult level represents the sum of the inert circulating depot, newly derived IGF-I synthesized from various tissues including liver, heart, kidney, bone, and others, and the departure from the circulation of IGF-I through mechanisms including receptor internalization and ...
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Molecular Biology of IGF-I and IGF-II
1999The molecular era for the insulin-like growth factors (IGFs) began in 1978 with the purification and amino acid sequencing of human IGF-I and IGF-II (1,2). During the past 20 yr, IGF proteins have been characterized from species as diverse as humans, chickens, frogs, and sharks, with the bulk of the information being obtained during the last decade ...
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Molecular Genetics Microbiology and Virology (Russian version), 2017
E. P. Kopantsev +3 more
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E. P. Kopantsev +3 more
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Journal of endocrinological investigation, 2005
All components of the IGF systems and all regulatory mechanisms known are present and active in bone tissue. Osteoblasts synthesize IGF-I and IGF-II which have mitogenic effects on bone cells. Although the relative productions of IGF-I and IGF-II by osteoblasts are different depending on different bone districts and experimental conditions, it seems ...
MINUTO, FRANCESCO +3 more
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All components of the IGF systems and all regulatory mechanisms known are present and active in bone tissue. Osteoblasts synthesize IGF-I and IGF-II which have mitogenic effects on bone cells. Although the relative productions of IGF-I and IGF-II by osteoblasts are different depending on different bone districts and experimental conditions, it seems ...
MINUTO, FRANCESCO +3 more
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Drugging IGF-1R in cancer: New insights and emerging opportunities
Genes and Diseases, 2023Lydia Wai Ting Cheung +1 more
exaly