Gene polymorphisms in primary biliary cirrhosis: association with the disease and hepatic osteopathy [PDF]
, 2007 Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis (PBC). Estrogen receptor-alpha gene (ER- ), vitamin-D-receptor gene (VDR) and IL-1-receptor-antagonist gene (IL-1RN) are all ...
Bajnok, Éva +6 more
core
Dietary alterations modulate the microRNA 29/30 and IGF-1/AKT signaling axis in breast Cancer liver metastasis. [PDF]
, 2020 Background: Metastatic cancer is incurable and understanding the molecular underpinnings is crucial to improving survival for our patients. The IGF-1/Akt signaling pathway is often impaired in cancer leading to its progression and metastases.
Camphausen, Kevin +5 more
core +1 more source
Cancer Communications, EarlyView.Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu +12 more
wiley +1 more source
Endocrine ReviewsAbstract There is strong evidence that IGF signaling is involved in fundamental aspects of the aging process. However, the extracellular part of the IGF system is complex with various receptors, ligand effectors, high-affinity IGF-binding proteins, proteinases, and endogenous inhibitors that all, along with their biological context, must
Cheryl A Conover, Claus Oxvig
openaire +1 more source
54 STRUCTURAL SIMILARITIES AND DIFFERENCES AMONG THE IGF BINDING PROTEINS PRESENT IN THE TWO MACROMOLECULAR FORMS OF SERUM [IGF-BP] COMPLEXES [PDF]
, 1985 S Hardouin +3 more
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Skeletal Muscle Memory: An Update From the Antidoping Perspective
Drug Testing and Analysis, EarlyView.ABSTRACT This narrative review explores the concept of muscle memory, focusing on the physiological and biochemical mechanisms underlying information retention in skeletal muscle tissue as it relates to antidoping. The discussion encompasses the role of satellite cells (SCs) in myonuclei recruitment, resulting in increased myonuclear density and ...
Claire Traversa
wiley +1 more source
SOMATOMEDIN-C (Sm-C/IGF-1) SYNERGISES WITH FIBROBLAST GROWTH FACTOR (FGF) ON SERTOLI CELLS (SC) MULTIPLICATION AND DIFFERENTIATION [PDF]
, 1988 P Chatelain +3 more
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IGF-1 enhances the osteogenic activity of BMP-6 in vitro and in vivo [PDF]
, 2017 Bone morphogenetic protein-2 (BMP-2) is widely used in orthopedic surgery and bone tissue engineering because of its strong osteogenic activity. However, BMP-2 treatments have several drawbacks and alternatives are being explored.
Becerra-Ratia, Jose +2 more
core
Drug Testing and Analysis, EarlyView.β‐hydroxy β‐methyl butyric acid (HMB), either as the free acid or in the form of its calcium salt, is a component of several dietary supplements marketed to enhance sports performance. We investigated the urinary excretion profile of HMB, also assessing the endogenous reference ranges of HMB in human urine samples from healthy volunteers (n = 20). Data
Cristian Camuto +3 more
wiley +1 more source
111 SERUM LEVELS OF IGF-I AND IGF-II IN CHILDREN TREATED WITH RECOMBINANT HUMAN GROWTH HORMONE (r-hGH) WITHOUT METHIONE [PDF]
, 1988 C De Campo +3 more
openalex +1 more source