Results 371 to 380 of about 396,798 (411)
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Hormone Research in Paediatrics, 2004
Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several animal models.
Joseph A M J L Janssen +1 more
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Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several animal models.
Joseph A M J L Janssen +1 more
openaire +3 more sources
Regulatory Peptides, 1994
To characterize the expression of the IGF-I system in the spleen and its role in spleen growth, we have studied the effect of hypophysectomy and the action of either GH or IGF-I treatment on the expression of several components of the IGF system in the rat.
Shoshana Yakar +6 more
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To characterize the expression of the IGF-I system in the spleen and its role in spleen growth, we have studied the effect of hypophysectomy and the action of either GH or IGF-I treatment on the expression of several components of the IGF system in the rat.
Shoshana Yakar +6 more
openaire +3 more sources
IGF-Independent Actions of the IGF Binding Proteins
1999The insulin-like growth factor binding proteins (IGFBPs) are members of the IGF signaling system, along with the ligands (insulin, IGF-I, and IGF-II) and a family of transmembrane receptors (the insulin, type 1 IGF and type 2 IGF receptors) (1–11). The human IGFBP superfamily consists of six high-affinity IGF binders (IGFBPs 1–6) and four low-affinity ...
Ron G. Rosenfeld, Youngman Oh
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Hormone and Metabolic Research, 1994
The insulin-like growth factor (IGF) axis is a multi-component network of molecules involved in the regulation of cell growth. The axis includes two major ligands, (IGF-I and IGF-II), cell surface receptors, (the type I IGF receptor family as well as the type II IGF receptor), a family of high affinity binding proteins which regulate IGF availability ...
Ron G. Rosenfeld +2 more
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The insulin-like growth factor (IGF) axis is a multi-component network of molecules involved in the regulation of cell growth. The axis includes two major ligands, (IGF-I and IGF-II), cell surface receptors, (the type I IGF receptor family as well as the type II IGF receptor), a family of high affinity binding proteins which regulate IGF availability ...
Ron G. Rosenfeld +2 more
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IGFs and their binding proteins
Nuclear Medicine and Biology, 1994Insulin-like growth factors (IGFs), initially known as somatomedins, and their specific, high-affinity binding proteins (IGFBPs) are synthesized in most tissues, but principally in the liver. The interest of measuring their circulating levels, which reflect liver production, is to obtain indications as to their endocrine function and regulation.
L Perin, Micheline Gourmelen, Y. Le Bouc
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IGF Binding Proteins as Modulators of IGF Action
1999The insulin-like growth factors (IGFs) are able to modulate an extraordinarily wide variety of biological actions. First described as stimulators of proteoglycan biosynthesis in cartilage (1,2), IGF peptides (then known as somatomedins or nonsuppressible insulin-like activity) were soon recognized as having insulin-like stimulatory effects on the ...
Robert C. Baxter, Janet L. Martin
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IGFS and Muscle Differentiation
1994The Role of IGFs in Myogenesis. Thus we are now convinced that the control of myogenesis by IGFs is a general phenomenon that occurs in all skeletal muscle cells, whether or not IGFs are added to the "differentiation" medium. We believe that several medium components contribute to the suppression of IGF-II expression in myoblasts incubated in high ...
K. A. Magri +3 more
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Annales d'Endocrinologie, 2016
Firstly discovered as a placental protein present abundantly in the circulation of pregnant women, pregnancy-associated plasma protein-A (PAPP-A) is widely expressed in multiple tissues. PAPP-A is a metalloproteinase that is able to specifically cleave three insulin-like growth factor binding proteins (IGFBPs): IGFBP-2, -4 and -5.
Monget, Philippe, Oxvig, Claus
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Firstly discovered as a placental protein present abundantly in the circulation of pregnant women, pregnancy-associated plasma protein-A (PAPP-A) is widely expressed in multiple tissues. PAPP-A is a metalloproteinase that is able to specifically cleave three insulin-like growth factor binding proteins (IGFBPs): IGFBP-2, -4 and -5.
Monget, Philippe, Oxvig, Claus
openaire +4 more sources
IGF, type I IGF receptor and IGF-binding protein mRNA expression in the developing mouse lung
Journal of Molecular Endocrinology, 1995ABSTRACT The IGFs are important mitogens involved in lung growth and development. The regulation of IGF action depends not only on the expression of IGFs and IGF receptors, but also on the modulation of IGF activity by IGF-binding proteins (IGFBPs). In this study, we describe the mRNA expression of IGF-I, IGF-II, type I IGF receptor, IGFBP-2, IGFBP-4 ...
Ellen Zwarthoff +4 more
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Expression and significance of IGF-1 and IGF-1R in thyroid nodules
Endocrine, 2013There are limitations in the diagnosis of thyroid nodules, especially follicular lesions, and their pathogenesis remains unclear. Insulin-like growth factor-1 (IGF-1) has been implicated in tumor cell apoptosis, transformation, invasion, and metastasis; however, its role in thyroid nodules is undetermined.
Wei Qiang +5 more
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