Results 381 to 390 of about 396,798 (411)

IGF-I and Osteoporosis

Clinics in Laboratory Medicine, 2000
Serum IGF-I is controlled by several different regulatory factors. The final adult level represents the sum of the inert circulating depot, newly derived IGF-I synthesized from various tissues including liver, heart, kidney, bone, and others, and the departure from the circulation of IGF-I through mechanisms including receptor internalization and ...
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Association of IGF-I and IGF-II with myofiber regeneration in vivo

Muscle & Nerve, 1999
This study examined expression of insulinlike growth factor (IGF) in the myofibers and nonmyofibrillar structures of murine soleus muscle following contraction-induced damage. Identifying the cellular sources of this myogenic growth factor could improve muscle rehabilitation strategies. Immunohistochemical analysis of muscle sections indicated that the
Keller, Heidi L., Schneider, Barbara St. Pierre, Eppihimer, Lois A., Cannon, Joseph G.   +3 more
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The IGF family and folliculogenesis

Journal of Reproductive Immunology, 1998
The process of ovarian follicular development is a long and arduous one, marked by dramatic proliferation and differentiation of both the somatic and germ cell elements. To a large extent, this explosive agenda is under the control of conventional endocrine principles, involving hormones such as pituitary gonadotropins and ovarian steroids. Importantly,
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Expression of IGF-II and IGF-binding proteins by colon cancer cells in relation to growth response to IGFs

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1994
We previously reported that even though virtually all human colon cancers were positive for IGF-I receptors, only 50% responded to growth effects of insulin-like growth factor (IGF)-I (1-100 nM). The present studies were undertaken to determine whether expression and secretion of IGFs (IGF-I, IGF-II) and IGF-binding proteins (BPs; 1-6) were perhaps ...
Chandrasekhar Yallampalli, Pomila Singh, Zhidong Xu, Bosong Dai   +3 more
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Molecular Biology of IGF-I and IGF-II

1999
The molecular era for the insulin-like growth factors (IGFs) began in 1978 with the purification and amino acid sequencing of human IGF-I and IGF-II (1,2). During the past 20 yr, IGF proteins have been characterized from species as diverse as humans, chickens, frogs, and sharks, with the bulk of the information being obtained during the last decade ...
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Passive immunization of insulin-like growth factor (IGF)-1 and of IGF-1 and IGF-2 in chickens

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1995
The effects of passive immunization against IGF-1 either alone, or together with immunization against IGF-2, on growth and metabolism were examined in chickens. Immunization against IGF-1 alone had no effect upon any aspect of growth, carcass composition, efficiency of energy utilization or hormone concentrations studied.
Jj Bass, G. S. G. Spencer, Eddy Decuypere, Michal Zeman, Sc Hodgkinson, Johan Buyse   +5 more
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IGF-dependent and IGF-independent actions of IGF-binding protein-1 and -2: implications for metabolic homeostasis

Trends in Endocrinology & Metabolism, 2009
Insulin-like growth factor (IGF)-binding proteins (IGFBPs) confer temporospatial regulation to IGF bioactivity. Both stimulatory and inhibitory effects of IGFBPs on IGF actions have been described, and IGF-independent effects of several IGFBPs are emerging.
Mark T. Kearney, Stephen B. Wheatcroft
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Expression of IGF-I and IGF-II mRNA in breast tissue [PDF]

Breast Cancer Research and Treatment, 1992
Expression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both
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IGF, type I IGF receptor and IGF-binding protein mRNA expression in kidney and liver of potassium-depleted and normal rats infused with IGF-I

Journal of Molecular Endocrinology, 1997
ABSTRACT Dietary potassium (K) depletion is known to reduce body weight gain and organ growth, except for kidney which increases in weight. This renal hypertrophy is preceded by increased renal IGF-I levels. In the present study, we investigated IGF-I and -II, type I IGF receptor and IGF-binding protein (IGFBP) mRNA expression in liver and kidney of K ...
M. Van Kleffens, I Dørup, A. Flyvbjerg, Roberto R. Rosato, Stenvert L. S. Drop, A G P Schuller, C Groffen, Dicky J. Lindenbergh-Kortleve, J W van Neck   +8 more
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IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1.

American Journal of Physiology. Endocrinology and Metabolism, 2004
Muscle atrophy results primarily from accelerated protein degradation and is associated with increased expression of two muscle-specific ubiquitin ligases (E3s): atrogin-1 and muscle ring finger 1 (MuRF1).
J. Sacheck, A. Ohtsuka, S. C. McLary, A. Goldberg   +3 more
semanticscholar   +1 more source