Results 391 to 400 of about 396,798 (411)

IGF Resistance: The Role of the Type 1 IGF Receptor

2005
The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is the dominant regulator of somatic growth in vertebrates. Growth deficits of varying severity follow experimental deletion of individual IGF axis components, with all but about 15% of the growth of an adult mouse explicable by the combined contributions of growth hormone and IGF-I ...
Robert Smith, Wieland Kiess, Anke Schneider, Steven D. Chernausek, Doreen Osgood, M. Jennifer Abuzzahab   +5 more
openaire   +2 more sources

Localization and regulation of IGF-I and IGF-II mRNA

1989
Insulin-like growth factors I and II (IGF-I and -H) are peptide mitogens that exert a wide range of biological actions in many tissues and cell types. The actions of the IGFs include metabolic and differentiative effects as well as their capacity to stimulate cell proliferation. (Humbel 1984; Froesch et al. 1985; Van Wyk 1984).
Pauline K. Lund, M. A. Hynes, J J Van Wyk, P. J. Brooks, J. English   +4 more
openaire   +2 more sources

Mechanism of activation of protein kinase B by insulin and IGF‐1.

EMBO Journal, 1996
D. Alessi, M. Andjelkovic, Barry Caudwell, P. Cron, N. Morrice, P. Cohen, B. Hemmings   +6 more
semanticscholar   +1 more source

IGF-I/IGF-IR signalling

Molecular Genetics Microbiology and Virology (Russian version), 2017
E. V. Grankina, M. R. Kopantseva, Eugene D. Sverdlov, E. P. Kopantsev   +3 more
openaire   +1 more source

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

Nature Cell Biology, 2001
C. Rommel, S. Bodine, B. A. Clarke, Roni Rossman, L. Nuñez, T. Stitt, G. Yancopoulos, D. Glass   +7 more
semanticscholar   +1 more source

Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis

The Lancet, 2004
A. Renehan, M. Zwahlen, C. Minder, S. O'dwyer, S. Shalet, M. Egger   +5 more
semanticscholar   +1 more source

The IGF story

2005
The insulin-like growth factor system is a complex system of peptide hormones IGF1 and IGF2, cell surface receptors (IGFR1 and IGFR2) and circulating binding proteins. IGF1 and IGF 2 are mitogens that play a role in regulating cell proliferation, differentiation and apoptosisTheir effects are mediated through the IGFR1 which initiate signaling cascades
openaire   +1 more source

Assays for GH, IGF-I, and IGF Binding Protein-3

2013
The growth hormone/insulin-like growth factor (GH/IGF) axis is widely investigated in disorders of growth, development, and anterior pituitary function. Methods are described for three hormones in this axis (growth hormone, IGF-I, and IGF binding protein-3).
openaire   +3 more sources

IGF binding proteins in cancer: mechanistic and clinical insights

Nature Reviews. Cancer, 2014
R. Baxter
semanticscholar   +1 more source

Adipogenesis and IGF-1

Metabolic Syndrome and Related Disorders, 2006
Jeffrey M P Holly, Claire M Perks, Matthew A. Sabin, Julian P.H. Shield   +3 more
openaire   +3 more sources