Results 71 to 80 of about 150,785 (321)

A one-year follow-up study of treatment-compliant suicide attempt survivors: relationship of CYP2D6-CYP2C19 and polypharmacy with suicide reattempts

Translational Psychiatry, 2022
This study of a cohort of 1-year treatment-compliant survivors of a suicide attempt examined for the first time whether a high CYP2D6-CYP2C19 metabolic capacity (pharmacogenes related to psychopathology, suicide, and attempt severity) and/or polypharmacy
Eva M. Peñas-Lledó, Sebastien Guillaume, Fernando de Andrés, Ana Cortés-Martínez, Jonathan Dubois, Jean Pierre Kahn, Marion Leboyer, Emilie Olié, Adrián LLerena, Philippe Courtet   +9 more
doaj   +1 more source

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Functional expression of CLIFAHDD and IHPRF pathogenic variants of the NALCN channel in neuronal cells reveals both gain- and loss-of-function properties

Scientific Reports, 2019
The excitability of neurons is tightly dependent on their ion channel repertoire. Among these channels, the leak sodium channel NALCN plays a crucial role in the maintenance of the resting membrane potential.
Malik Bouasse, Hathaichanok Impheng, Zoe Servant, Philippe Lory, Arnaud Monteil   +4 more
doaj   +1 more source

Share, but unequally: A plausible mechanism for emergence and maintenance of intratumor heterogeneity [PDF]

arXiv, 2018
Intratumor heterogeneity (ITH), referring to coexistence of different cell subpopulations in a single tumor, has been a major puzzle in cancer research for almost half a century. The lack of understanding of the underlying mechanism of ITH hinders progress in developing effective therapies for cancers.
arxiv  

m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

Advanced Science, EarlyView.
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li, Mengzhen Han, He Zhu, Yonglong Pan, Chen Su, Yachong Liu, Zhibin Liao, Bixiang Zhang, Xiaoping Chen   +8 more
wiley   +1 more source

Multi-Sensor Instrument for Aerosol In Situ Measurements

Atmosphere
A short comparison campaign took place at the Racibórz measurement site in May 2024 to assess the consistency of the Integrated Aerosol Monitoring Unit (IAMU), which houses three PM aerosol sensors (SPS30, OPC-N3, and OPS 3330) within a single enclosure.
Ilya Bruchkouski, Artur Szkop, Jakub Wink, Justyna Szymkowska, Aleksander Pietruczuk   +4 more
doaj   +1 more source

Progastrin production transitions from Bmi1+/Prox1+ to Lgr5high cells during early intestinal tumorigenesis

Translational Oncology, 2021
Progastrin is an unprocessed soluble peptide precursor with a well-described tumor-promoting role in colorectal cancer. It is expressed at small levels in the healthy intestinal mucosa, and its expression is enhanced at early stages of intestinal tumor ...
J. Giraud, M. Foroutan, J. Boubaker-Vitre, F. Grillet, Z. Homayed, U. Jadhav, P. Crespy, C. Breuker, J-F. Bourgaux, J. Hazerbroucq, C. Pignodel, B. Brulin, R.A. Shivdasani, P. Jay, F. Hollande, J. Pannequin   +15 more
doaj  

Quasiparticle Many-Body Dynamics of Highly Correlated Electronic Systems [PDF]

arXiv, 1997
The self-consistent theory of the correlation effects in Highly Correlated Systems(HCS) is presented. The novel Irreducible Green's Functions(IGF) method is discused in detail for the Hubbard model and random Hubbard model. The interpolative solution for the quasiparticle spectrum, which is valid for both the atomic and band limit is obtained. The (IGF)
arxiv  

Role of Correlation and Exchange for Quasi-particle Spectra of Magnetic and Diluted Magnetic Semiconductors [PDF]

, 2004
Theoretical foundation and application of the generalized spin-fermion (sp-d) exchange lattice model to magnetic and diluted magnetic semiconductors are discussed. The capabilities of the model to describe spin quasi-particle spectra are investigated. The main emphasis is made on the dynamic behavior of two interacting subsystems, the localized spins ...
arxiv   +1 more source

Loss of IGF-IEa or IGF-IEb Impairs Myogenic Differentiation [PDF]

Endocrinology, 2011
Actions of protein products resulting from alternative splicing of the Igf1 gene have received increasing attention in recent years. However, the significance and functional relevance of these observations remain poorly defined. To address functions of IGF-I splice variants, we examined the impact of loss of IGF-IEa and IGF-IEb on the proliferation and
Ronald W. Matheny, Bradley C. Nindl
openaire   +3 more sources