Results 81 to 90 of about 177,776 (291)

The same but different: impact of animal facility sanitary status on a transgenic mouse model of Alzheimer’s disease

mBio
The gut-brain axis has emerged as a key player in the regulation of brain function and cognitive health. Gut microbiota dysbiosis has been observed in preclinical models of Alzheimer’s disease and patients.
Caroline Ismeurt-Walmsley, Patrizia Giannoni, Florence Servant, Linda-Nora Mekki, Kevin Baranger, Santiago Rivera, Philippe Marin, Benjamin Lelouvier, Sylvie Claeysen   +8 more
doaj   +1 more source

Significant polyomic and functional upregulation of the PAPP‐A/IGFBP‐4/5/IGF‐1 axis in chronic rhinosinusitis with nasal polyps [PDF]

, 2020
Sarina K. Mueller, Angela L. Nocera, Alan D. Workman, Towia A. Libermann, Simon T. Dillon, Achim Stegmann, Jochen Wurm, Heinrich Iro, Olaf Wendler, Benjamin S. Bleier   +9 more
openalex   +1 more source

Determination of the Entropic Heat Coefficient of Lithium‐Ion Batteries Based on a Continuous Measurement Method

Batteries &Supercaps, EarlyView.
Understanding thermal battery behavior is essential for performance, safety, and longevity in automotive applications. This work presents a method to determine entropic‐heat coefficients using continuous quasi‐open‐circuit‐voltage measurements. The method's accuracy and robustness are validated through comparison with potentiometric measurements ...
Anne Heß, Thomas Wetzel, Philipp Seegert   +2 more
wiley   +1 more source

Protocol for in vivo recording of neural activity in deep structures of mice brain via gradient lenses by calcium imaging

STAR Protocols
Summary: Calcium (Ca2+) imaging is a viable approach for imaging neuronal activity patterns in local brain circuits in living animals. Here, we present a protocol for gradient lens implantation in deep brain structures followed by in vivo Ca2+ imaging ...
Stanislav Cherepanov, Patrice Mollard, Agnes O. Martin   +2 more
doaj   +1 more source

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond

BMEMat, EarlyView.
Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra   +8 more
wiley   +1 more source

Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD

Developmental Dynamics, EarlyView.
Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim, You‐Lim Hwang, Sunwoo Yeom, Seung‐Hae Kwon, Sang‐Hak Jeon   +4 more
wiley   +1 more source

Osteoblast-specific Knockout of the Insulin-like Growth Factor (IGF) Receptor Gene Reveals an Essential Role of IGF Signaling in Bone Matrix Mineralization [PDF]

, 2002
Mei Zhang, Shouhong Xuan, Mary Bouxsein, D. von Stechow, Nagako Akeno, M.-C. Faugere, Hartmut H. Malluche, Guisheng Zhao, Clifford J. Rosen, Argiris Efstratiadis, Thomas L. Clemens   +10 more
openalex   +1 more source

Reduced Oligodendrocyte Density and Axonal Caliber Associated With Mitochondrial Alterations in the White Matter of Chronically‐Starved Mice

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with extreme weight loss, hyperactivity, and amenorrhea. Neuroimaging studies revealed brain atrophy and disruption of white matter integrity in the corpus callosum (CC) of patients with AN. However, the underlying pathophysiological mechanisms remain unclear.
Stephan Lang, Annelie Zimmermann, Kaja Dickert, Hanna Rupprecht, Julia Priebe, Fabienne Haberland, Hanna‐Sophia Henschke, Katharina Schuster, Marcus Frank, Linda Frintrop   +9 more
wiley   +1 more source

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway [PDF]

, 2017
Jian-Guo Ren, Pankaj Seth, Huihui Ye, Kun Guo, Jun‐ichi Hanai, Zaheed Husain, Vikas P. Sukhatme   +6 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source