Results 81 to 90 of about 151,710 (240)
STAR ProtocolsSummary: Calcium (Ca2+) imaging is a viable approach for imaging neuronal activity patterns in local brain circuits in living animals. Here, we present a protocol for gradient lens implantation in deep brain structures followed by in vivo Ca2+ imaging ...
Stanislav Cherepanov +2 more
doaj +1 more source
Arthritis &Rheumatology, Accepted Article.Objectives We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine OA models that vary in severity of pathology and rate of progression, to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt +18 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond
BMEMat, EarlyView.Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad +8 more
wiley +1 more source
BMEMat, EarlyView.The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang +6 more
wiley +1 more source
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, EarlyView.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Influence of Particle Size, Moisture, and Cloud Density on Wood Dust Ignition
Chemie Ingenieur Technik, EarlyView.The ignition and combustion of particle clouds are strongly affected by particle interactions. This study uses spectroscopy to examine effects of particle size, water content, and cloud density. Results show ignition delay rises with larger size and density, whereas combustion duration depends mainly on water and density due to moisture‐driven ...
Matteo Giesen +2 more
wiley +1 more source
IGF-1 and IGF-1 SDS – fit for purpose? [PDF]
European Journal of Endocrinology, 2019 Kos, S. +7 more
openaire +5 more sources
Drug Testing and Analysis, EarlyView.New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley +1 more source