Results 1 to 10 of about 24,582 (143)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo [PDF]

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +2 more sources

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery [PDF]

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +2 more sources

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management [PDF]

International Journal of Cancer, Volume 159, Issue 11, Page 2736-2754, 1 December 2026.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +2 more sources

Insulin-like growth factor 2 as a central regulator of growth and metabolic efficiency in livestock: Genetic, nutritional, and biotechnological perspectives [PDF]

Veterinary World
Background and Aim: Efficient livestock production depends on integrating genetic, nutritional, and management strategies to improve growth, feed efficiency, and product quality.
Siti Rani Ayuti, Eun Joong Kim, Sangsu Shin, Mirni Lamid, Widya Paramita Lokapirnasari, Mohammad Anam Al Arif, Sunaryo Hadi Warsito, Zulfi Nur Amrina Rosyada, Aswin Rafif Khairullah, Teuku Reza Ferasyi, Mustafa Sabri, Rimayanti Rimayanti, Wasito Wasito, Riza Zainuddin Ahmad   +13 more
doaj   +2 more sources

Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood

EBioMedicine, 2017
Insulin-like Growth Factor 2 (IGF2) belongs to the IGF/Insulin pathway, a highly conserved evolutionarily network that regulates growth, aging and lifespan. Igf2 is highly expressed in the embryo and in cancer cells.
Daniel Lewandowski, Vilma Barroca
exaly   +3 more sources

PCR-RFLP Analysis of Insulin-Like Growth Factor 2 Gene Polymorphisms in Two Commercial Broiler Chicken Strains (Cobb 500 and Hubbard F-15) and Their Associations with Performance Traits [PDF]

Archives of Razi Institute, 2023
The present research aimed to study the polymorphisms of the chicken insulin-like growth factor 2 (IGF2) in two commercial broiler breeds (Cobb 500 and Hubbard F-15). In total, 300 avian blood samples were obtained.
A. S Al-Hassani, D. H Al-Hassani, I. A Abdul-Hassan   +2 more
doaj   +1 more source

Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2

Communications Biology, 2023
Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 proforms, big-IGF2(87)
Pavlo Potalitsyn, Lucie Mrázková, Irena Selicharová, Michaela Tencerová, Michaela Ferenčáková, Martina Chrudinová, Tereza Turnovská, Andrzej Marek Brzozowski, Aleš Marek, Jakub Kaminský, Jiří Jiráček, Lenka Žáková   +11 more
doaj   +1 more source

Fluid Shear Stress-Induced Exosomes from Liver Cancer Cells Promote Activation of Cancer-Associated Fibroblasts via IGF2-PI3K Axis

Frontiers in Bioscience-Landmark, 2022
Background: Cancer-associated fibroblasts (CAFs) are of considerable importance in tumor progression by interacting with the tumor microenvironment.
Tang Feng, Fei Fang, Chunhe Zhang, Tiantian Li, Jia He, Yang Shen, Hongchi Yu, Xiaoheng Liu   +7 more
doaj   +1 more source

ZBED6 regulates Igf2 expression partially through its regulation of miR483 expression

Scientific Reports, 2021
The expression of Igf2 in mammals shows a complex regulation involving multiple promoters and epigenetic mechanisms. We previously identified a novel regulatory mechanism based on the interaction between the transcriptional factor ZBED6 and Igf2 intron ...
Rakan Naboulsi, Mårten Larsson, Leif Andersson, Shady Younis   +3 more
doaj   +1 more source

Fresh autologous blood transfusion reverses erythrocytes damage by reducing oxidative stress via promoting mitochondrial metabolism and M2 macrophages polarization

Archives of Medical Science, 2022
Introduction Systemic inflammatory and immunosuppressive incidents constitute a significant hallmark of the adverse effects of RBC transfusion on red blood cells. These adverse side effects are seemingly associated with old blood transfusions; therefore,
Jia-Ming Xu, Lai-Wei You, Xiao-Fang Zhou, Yu Bai, Yong Cheng, Ying-Hui Cui, Xiao-Fei Chen, Jian-Rong Guo   +7 more
doaj   +1 more source