Results 21 to 30 of about 29,583 (184)

Association of Genetic Variants in IGF2-Related Genes With Risk of Metabolic Syndrome in the Chinese Han Population

Frontiers in Endocrinology, 2021
AimsTo explore associations between polymorphisms of IGF2-related genes including H19, IGF2, IGF2BP2 and IGF2R and Metabolic syndrome (MetS) susceptibility in the Chinese Han population.Methods66 subjects with MetS and 257 control subjects were collected
Weiwei Gui, Julong Liang, Xihua Lin, Nanjing Shi, Yiyi Zhu, Bowen Tan, Hong Li   +6 more
doaj   +1 more source

Noncanonical regulation of imprinted gene Igf2 by amyloid-beta 1–42 in Alzheimer’s disease

Scientific Reports, 2023
Reduced insulin-like growth factor 2 (IGF2) levels in Alzheimer’s disease (AD) may be the mechanism relating age-related metabolic disorders to dementia.
Emre Fertan, William H. Gendron, Aimée A. Wong, Gabrielle M. Hanson, Richard E. Brown, Ian C. G. Weaver   +5 more
doaj   +1 more source

IGF2 and IGF1R mRNAs Are Detectable in Human Spermatozoa

The World Journal of Men's Health, 2020
Purpose: Oligozoospermia is highly prevalent worldwide. Studies have reported a lower methylation rate in the H19 differentially methylated region at the sperm level in oligozoospermic patients than in controls.
Rossella Cannarella, Rosita A. Condorelli, Sandro La Vignera, Catia Bellucci, Giovanni Luca, Riccardo Calafiore, Aldo E. Calogero   +6 more
doaj   +1 more source

An association of C/T polymorphism in exon 2 of the bovine insulin-like growth factor 2 gene with meat production traits in Polish Holstein-Friesian cattle

Czech Journal of Animal Science, 2010
The effect of the insulin-like growth factor 2 (IGF2) gene polymorphism - a g.292C>T transition in exon 2 on feed uptake and conversion, growth rates, and meat production traits in Polish Holstein-Friesian cattle was investigated. A total of 291 young
L. Zwierzchowski, E. Siadkowska, J. Oprządek, K. Flisikowski, E. Dymnicki   +4 more
doaj   +1 more source

Intrathecal injection of IGF2 siRNA decreases IGF2 protein expression in the spinal cord.

, 2021
Western blotting analysis for IGF2 in protein extracts from spinal cord tissue in different groups and timepoints. (A) Left, comparison of IGF2 protein expression levels in the spinal cord dorsal horn in the sham group and in the SNI + IGF2 siRNA group ...
Feng-Yen Lin (143413), Nian-Cih Huang (11785307), Chun-Chang Yeh (734562), Yi-Wen Lin (143406), Wei-Hung Chan (11785304), Chien-Sung Tsai (484479)   +5 more
core   +1 more source

IGF2 and preptin, biologically active peptides derived from pro-IGF2 [PDF]

, 2021
Pro-IGF2 is a 156 amino acid long protein and it is a prohormone from which two bio- logically active peptides are formed, IGF2 and preptin. IGF2 is an insulin-like growth factor 2 that, together with IGF1 and insulin, shares a similar 3-D structure and ...
Mrázková, Lucie
core  

Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis

Open Medicine, 2023
The aim of our study is to disclose the role and underlying molecular mechanisms of circular RNA ubiquitin protein ligase E3 component n-recognin 4 (circ-UBR4) in atherosclerosis (AS).
Feng Liuliu, Liu Tianhua, Shi Jun, Wang Yu, Yang Yuya, Xiao Wenyin, Bai Yanyan   +6 more
doaj   +1 more source

Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway

Open Medicine, 2023
Circular RNA (circRNA) is involved in the pathogenesis of atherosclerosis (AS). The present work analyzed the RNA expression of circ_0113656, microRNA-188-3p (miR-188-3p), and insulin-like growth factor 2 (IGF2) by quantitative real-time polymerase chain
Yang Ming, Luo Jun, Zhang Shuhua, Huang Qing, Cao Qianqiang   +4 more
doaj   +1 more source

Genomic imprinting defects in the growth disorder Beckwith-Wiedemann syndrome [PDF]

, 2009
The imprinting control region (IC1) of the human IGF2 and H19 genes is represented by a chromatin insulator located between the two genes that prevents the activation of IGF2 and allows the activation of H19 on the maternal chromosome. Deletions removing
Citro, Valentina
core   +1 more source

Genetic structure and population dynamics of autochthonous and modern porcine breeds. Analysis of the IGF2 and MC4R genes that determine carcass characteristics

Austral Journal of Veterinary Sciences, 2020
To know the genetic situation of the Pampa Rocha, Celta, Bizaro Portuguese, Duroc, Iberian Extremeño and Iberian Andalusian porcine populations, their genetic structure and population dynamics were studied on the IGF2 and MC4R genes, which determine meat
Silvia Llambí, María Montenegro, Rosa Gagliardi, Carmen Burgos, Jorge Hidalgo, Pascual López-Buesa, María V. Arruga   +6 more
doaj   +1 more source