Results 11 to 20 of about 29,583 (184)

Different epigenetic alterations are associated with abnormal IGF2/Igf2 upregulation in neural tube defects. [PDF]

PLoS ONE, 2014
The methylation status of DNA methylation regions (DMRs) of the imprinted gene IGF2/Igf2 is associated with neural tube defects (NTDs), which are caused by a failure of the neural tube to fold and close and are the second-most common birth defect ...
Baoling Bai, Qin Zhang, Xiaozhen Liu, Chunyue Miao, Shaofang Shangguan, Yihua Bao, Jin Guo, Li Wang, Ting Zhang, Huili Li   +9 more
doaj   +2 more sources

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis [PDF]

BMC Cancer, 2019
Background Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere with rhabdomyosarcoma growth, no ...
Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini, Pier-Luigi Lollini   +7 more
doaj   +2 more sources

Overexpression of IGF2 affects mouse weight and glycolipid metabolism and IGF2 is positively related to macrosomia [PDF]

Frontiers in Endocrinology, 2023
ObjectiveTo investigate the effects of insulin-like growth factor 2 (IGF2) on growth and glycolipid metabolism, as well as the underlying mechanism.MethodsA mouse model of IGF2 overexpression was constructed to measure weight gain before adulthood, to ...
Qidi Zhang, Shengtang Qin, Jing Huai, Huixia Yang, Yumei Wei   +4 more
doaj   +2 more sources

Relationship of porcine IGF2 imprinting status to DNA methylation at the H19 DMD and the IGF2 DMRs 1 and 2 [PDF]

BMC Genetics, 2011
Background Porcine IGF2 and the H19 genes are imprinted. The IGF2 is paternally expressed, while the H19 gene is maternally expressed. Extensive studies in mice established a boundary model indicating that the H19 differentially methylated domain (DMD ...
Owczarek-Lipska Marta, Braunschweig Martin H, Stahlberger-Saitbekova Nasikhat   +2 more
doaj   +3 more sources

Promoter-specific expression and imprint status of marsupial IGF2. [PDF]

PLoS ONE, 2012
In mice and humans, IGF2 has multiple promoters to maintain its complex tissue- and developmental stage-specific imprinting and expression. IGF2 is also imprinted in marsupials, but little is known about its promoter region.
Jessica M Stringer, Shunsuke Suzuki, Andrew J Pask, Geoff Shaw, Marilyn B Renfree   +4 more
doaj   +3 more sources

IGF2 promotes growth of adrenocortical carcinoma cells, but its overexpression does not modify phenotypic and molecular features of adrenocortical carcinoma. [PDF]

PLoS ONE, 2014
Insulin-like growth factor 2 (IGF2) overexpression is an important molecular marker of adrenocortical carcinoma (ACC), which is a rare but devastating endocrine cancer.
Marine Guillaud-Bataille, Bruno Ragazzon, Aurélien de Reyniès, Claire Chevalier, Isabelle Francillard, Olivia Barreau, Virginie Steunou, Johann Guillemot, Frédérique Tissier, Marthe Rizk-Rabin, Fernande René-Corail, Abir Al Ghuzlan, Guillaume Assié, Xavier Bertagna, Eric Baudin, Yves Le Bouc, Jérôme Bertherat, Eric Clauser   +17 more
doaj   +1 more source

Single nucleotide polymorphisms at the imprinted bovine insulin-like growth factor 2 (IGF2) locus are associated with dairy performance in Irish Holstein-Friesian cattle [PDF]

, 2010
peer-reviewedThe imprinted insulin-like growth factor 2 gene (IGF2) encodes a fetal mitogenic hormone protein (IGF-II) and has previously been shown to be associated with performance in dairy cattle.
Berkowicz, Erik W, Magee, David A, Evans, R. D., Spillane, Charles, Mullen, Michael P., Sikora, Klaudia M, MacHugh, David E, Howard, Dawn J., Berry, Donagh   +8 more
core   +1 more source

Combined QTL and Genome Scan Analyses With the Help of 2b-RAD Identify Growth-Associated Genetic Markers in a New Fast-Growing Carp Strain

Frontiers in Genetics, 2018
Common carp is one of the oldest and most popular cultured freshwater fish species both globally and in China. In a previous study, we used a carp strain with a long breeding tradition in China, named Huanghe, to create a new fast-growing strain by ...
Shengyan Su, Shengyan Su, Hengde Li, Fukuan Du, Chengfeng Zhang, Chengfeng Zhang, Xinyuan Li, Xiaojun Jing, Xiaojun Jing, Liyue Liu, Zhixun Li, Xingli Yang, Pao Xu, Pao Xu, Xinhua Yuan, Xinhua Yuan, Jian Zhu, Jian Zhu, Raouf Bouzoualegh   +18 more
doaj   +1 more source

Modeling human epigenetic disorders in mice: Beckwith-Wiedemann syndrome and Silver-Russell syndrome

Disease Models & Mechanisms, 2020
Genomic imprinting, a phenomenon in which the two parental alleles are regulated differently, is observed in mammals, marsupials and a few other species, including seed-bearing plants. Dysregulation of genomic imprinting can cause developmental disorders
Suhee Chang, Marisa S. Bartolomei
doaj   +1 more source

Number and mode of inheritance of QTL influencing backfat thickness on SSC2p in Sino-European pig pedigrees [PDF]

, 2011
Background In the pig, multiple QTL associated with growth and fatness traits have been mapped to chromosome 2 (SSC2) and among these, at least one shows paternal expression due to the IGF2-intron3-G3072A substitution. Previously published results on the
Gilbert Hélène, Heuven, H.C.M., Riquet, J., Advances in Veterinary Medicine, Bidanel, Jean Pierre, Heuven, Henri CM, Henri CM Heuven, Bidanel, J-P., Bidanel, J.P., Riquet, Juliette, Groenen, Martien AM, Tortereau, F.J.D., Hélène Gilbert, Tortereau Flavie, Geneeskunde van gezelschapsdieren, Riquet Juliette, Groenen Martien AM, Jean-Pierre Bidanel, Heuven Henri CM, Gilbert, Hélène, Flavie Tortereau, Tortereau, F., Martien AM Groenen, Groenen, M.A.M., Bidanel Jean-Pierre, Gilbert, H.J., Gilbert, H., Juliette Riquet   +27 more
core   +2 more sources