Results 1 to 10 of about 359,562 (114)

Insulin-like Growth Factor-2 (IGF-2) in Fibrosis [PDF]

Biomolecules, 2022
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins.
Yuhan Zhu, Lin Chen, Binyu Song, Zhiwei Cui, Guo Chen, Zhou Yu, Baoqiang Song   +6 more
doaj   +2 more sources

Activation of the insulin receptor by insulin-like growth factor 2 [PDF]

Nature Communications
Insulin receptor (IR) controls growth and metabolism. Insulin-like growth factor 2 (IGF2) has different binding properties on two IR isoforms, mimicking insulin’s function.
Weidong An, Catherine Hall, Jie Li, Albert Hung, Jiayi Wu, Junhee Park, Liwei Wang, Xiao-chen Bai, Eunhee Choi   +8 more
doaj   +2 more sources

Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations [PDF]

Frontiers in Neurology
BackgroundCerebral arteriovenous malformations (AVMs) are intricate vascular anomalies that disrupt normal cerebral blood flow, potentially leading to severe neurological complications.
Lin-jian Wang, Lin-jian Wang, Lin-jian Wang, Yangyang Wu, Yangyang Wu, Yangyang Wu, Sha Xie, Hongkai Lian, Hongkai Lian, Hongkai Lian   +9 more
doaj   +2 more sources

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hematological diseases [PDF]

Molecular Medicine
The oncofetal mRNA-binding protein IGF2BP1 belongs to a conserved family of RNA-binding proteins. It primarily promotes RNA stability, regulates translation and RNA localization, and mediates gene expression through its downstream effectors.
Shuangping Ma, Yiran Qin, Wenjie Ren
doaj   +2 more sources

Insulin-like growth factor type 2 is a better survival marker than insulin-like growth factor type 1 in patients after acute decompensated heart failure

Archives of Medical Science, 2023
Introduction A decreased insulin-like growth factor 1 (IGF-1) level has been found in heart failure (HF). There are no reports assessing IGF-2 in HF, although in vitro research has shown that IGF-2 stimulates cardiomyocyte proliferation more than IGF-1 ...
Agata Bronisz, Bartosz J. Myśliwiec, Magdalena Hagner–Derengowska, John Xerri de Caro, Marek Bronisz   +4 more
doaj   +1 more source

Neuroprotective effects of insulin-like growth factor-2 in 6-hydroxydopamine-induced cellular and mouse models of Parkinson’s disease

Neural Regeneration Research, 2023
Skin-derived precursor Schwann cells have been reported to play a protective role in the central nervous system. The neuroprotective effects of skin-derived precursor Schwann cells may be attributable to the release of growth factors that nourish host ...
Hai-Ying Zhang, Yong-Cheng Jiang, Jun-Rui Li, Jia-Nan Yan, Xin-Jue Wang, Jia-Bing Shen, Kai-Fu Ke, Xiao-Su Gu   +7 more
doaj   +1 more source

Activation of Proneuronal Transcription Factor Ascl1 in Maternal Liver Ensures a Healthy PregnancySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Maternal liver shows robust adaptations to pregnancy to accommodate the metabolic needs of the developing and growing placenta and fetus by largely unknown mechanisms.
Joonyong Lee, Veronica Garcia, Shashank M. Nambiar, Huaizhou Jiang, Guoli Dai   +4 more
doaj   +1 more source

Alteration in Expression and Methylation of IGF2/H19 in Placenta and Umbilical Cord Blood Are Associated with Macrosomia Exposed to Intrauterine Hyperglycemia. [PDF]

PLoS ONE, 2016
OBJECTIVE:Macrosomia is one of the most common complications in gestational diabetes mellitus. Insulin-like growth factor 2 and H19 are two of the imprinted candidate genes that are involved in fetal growth and development.
Rina Su, Chen Wang, Hui Feng, Li Lin, Xinyue Liu, Yumei Wei, Huixia Yang   +6 more
doaj   +1 more source

Development of real-time reverse transcription polymerase chain reaction assays to quantify insulin-like growth factor receptor and insulin receptor expression in equine tissue

Onderstepoort Journal of Veterinary Research, 2013
The insulin-like growth factor system (insulin-like growth factor 1, insulin-like growth factor 2, insulin-like growth factor 1 receptor, insulin-like growth factor 2 receptor and six insulin-like growth factor-binding proteins) and insulin are essential
Stephen B. Hughes, Melvyn Quan, Alan Guthrie, Martin Schulman   +3 more
doaj   +1 more source

The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance

Technology in Cancer Research & Treatment, 2020
RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients ...
Jing Zhang MS, Fanghui Ding MD, Dan Jiao MS, Qiaozhi Li MS, Hong Ma MS   +4 more
doaj   +1 more source