Results 51 to 60 of about 29,583 (184)

IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in d-galactose-induced aging mice

Molecular Medicine, 2023
Background Liver aging, marked by cellular senescence and low-grade inflammation, heightens susceptibility to chronic liver disease and worsens its prognosis.
Xiaohai Zhou, Bowen Tan, Weiwei Gui, Caiping Zhou, Hanxin Zhao, Xihua Lin, Hong Li   +6 more
doaj   +1 more source

MiniSdd7‐Derived Cytosine Base Editor Promotes Efficient Multiplex Gene Knockout in Porcine Primary Fibroblasts

Animal Research and One Health, EarlyView.
The miniSdd7‐BE4max‐SpG system enables highly efficient multiplex C‐to‐T base editing of APN, CD163, and MSTN in porcine fibroblasts, providing a robust platform for future development of multiplex gene‐edited livestock. ABSTRACT Efficient multiplex genome editing is essential for improving complex traits in livestock that are governed by multiple ...
Shaoshuai Wang, Yu Wang, Dengfeng Bi, Jianguo Zhao, Yanfang Wang   +4 more
wiley   +1 more source

The insulin-like growth factor 2 gene in mammals: Organizational complexity within a conserved locus.

PLoS ONE, 2019
The secreted protein, insulin-like growth factor 2 (IGF2), plays a central role in fetal and prenatal growth and development, and is regulated at the genetic level by parental imprinting, being expressed predominantly from the paternally derived ...
Kabita Baral, Peter Rotwein
doaj   +1 more source

A biomechanical optimized Zr58Cu25Al14Nb3 bulk metallic glass dental implant improves peri‐implant stress distribution and bone quality under physiological loading

BMEMat, EarlyView.
This study reports a novel Zr58Cu25Al14Nb3 bulk metallic glass that possesses high mechanical strength and low elastic modulus, which further promotes efficient mechanotransduction and significantly improves peri‐implant bone quality upon cyclic occlusal loading.
Yunshu Wu, Feifei Wang, Yuan He, Yaopeng Zhang, Yuhao Zeng, Fu Zheng, Zhanqi Wei, Sukun Tian, Kinon Chen, Baoan Sun, Yuchun Sun   +10 more
wiley   +1 more source

IGF2 expression in blood is not associated with its imprinting status in healthy pregnant Chinese women

Biological Research, 2012
Loss of Imprinting (LOI) of IGF2 and over-expressed IGF2 are associated with tumorigenesis. Our previous epidemiological study found a relatively high frequency of IGF2 LOI in healthy mid-gestation pregnant women.
Gao Ru-Fei, Liu Xue-Qing, Wang Ying-Xiong, Chen Xue-Mei, Ding Yu-Bin, He Jun-Lin   +5 more
doaj  

Mir-483-5p-mediated activating of IGF2/H19 enhancer up-regulates IGF2/H19 expression via chromatin loops to promote the malignant progression of hepatocellular carcinoma

Molecular Cancer
Background The insulin-like growth factor 2 (IGF2) and H19 are overexpressed in hepatocellular carcinoma (HCC). IGF2-derived miR-483-5p is implicated in the development of cancers.
Weiwei Chen, Chutian Wu, Yuting Li, Tonghua Wang, Miaoling Huang, Min Wang, Linjing Long, Yanfang Chen, Shufen Feng, Xuyou Liu, Shaohui Tang   +10 more
doaj   +1 more source

Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes

Cell Reports, 2021
Summary: Beckwith-Wiedemann syndrome (BWS) and Silver-Russell syndrome (SRS) are imprinting disorders manifesting as aberrant fetal growth and severe postnatal-growth-related complications.
Ji Liao, Tie-Bo Zeng, Nicholas Pierce, Diana A. Tran, Purnima Singh, Jeffrey R. Mann, Piroska E. Szabó   +6 more
doaj   +1 more source

The womb as the cradle of longevity: Perinatal origins of biological aging

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley   +1 more source

Loss of imprinting of IGF2 characterises high IGF2 mRNA-expressing type of fibroblast-like synoviocytes in rheumatoid arthritis [PDF]

, 2010
OBJECTIVE: Increased expression of insulin-like growth factor 2 (IGF2) by fibroblast-like synoviocytes (FLS) was associated with low inflammatory synovium of patients with rheumatoid arthritis (RA).
van Rietschoten, J.G.I., Tak, Paul P., Pouw Kraan, C.T.M. van der, Marsal, Sara, Marsal, S., Ibrahim, Saleh M., Verweij, Cornelis L., Tak, P.P., Huizinga, T.W.J., Dijkmans, B.A.C., Martin-Trujillo, A., Timmer, Trieneke C. G., Huizinga, Tom W. J., van der Pouw Kraan, C.T.M., Ibrahim, S.M., van Rietschoten, Johanna G. I., Dijkmans, Ben A. C., Rodríguez, Francisco Milena, Verweij, C.L., Timmer, T.C.G., Kraan, T.C.T.M.V., Martin-Trujillo, Alejandro, van der Pouw Kraan, Tineke C. T. M., Rodriguez, F.M., Rietschoten, J.G.I. van, Timmer, C.G., van der Kraan, T.C.T.M.   +26 more
core   +2 more sources

Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA

eLife, 2021
Maternal loss of imprinting (LOI) at the H19/IGF2 locus results in biallelic IGF2 and reduced H19 expression and is associated with Beckwith–-Wiedemann syndrome (BWS).
Ki-Sun Park, Beenish Rahat, Hyung Chul Lee, Zu-Xi Yu, Jacob Noeker, Apratim Mitra, Connor M Kean, Russell H Knutsen, Danielle Springer, Claudia M Gebert, Beth A Kozel, Karl Pfeifer   +11 more
doaj   +1 more source