Results 101 to 110 of about 427,117 (288)
Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models
Advanced Science, EarlyView.Distal/connecting tubules expressing SLC8A1 have been suggested as a potential origin of ARPKD cysts. SPTAN1 has been identified as a key molecule in ARPKD cyst formation. Restoring SPTAN1 in PKHD1−/− organoids reduced cyst formation, normalized calcium levels, and decreased RAC1/c‐FOS expression, highlighting SPTAN1's role in ARPKD and the potential ...
Shohei Kuraoka +9 more
wiley +1 more source
Scientific Reports, 2018 Combination of multifunctionalities into one compound is a rational strategy in medicinal chemical design, and have often been used with metallodrug-based compounds.
Valdenizia Rodrigues Silva +5 more
doaj +1 more source
Radiation Backgrounds at Cosmic Dawn: X-Rays from Compact Binaries
, 2017 We compute the expected X-ray diffuse background and radiative feedback on the intergalactic medium (IGM) from X-ray binaries prior and during the epoch of reionization.
Fragos, Tassos, Madau, Piero
core +2 more sources
SCCA1–IGM and SCCA2–IGM Compared with Total SCCA-IGM for Diagnosis of Hepatocellular Carcinoma
The International Journal of Biological Markers, 2009 Introduction SCCA1 and SCCA2 belong to the family of serine protease inhibitors (SERPIN). Both SCCA isoforms have been found to be increased in patients with squamous cell carcinoma (SCC) of different organs. Recent findings have demonstrated that SCCA-IgM immune complexes are a novel class of biomarkers for primary liver cancer detection.
BIASIOLO, ALESSANDRA +6 more
openaire +2 more sources
Peroxidase‐Mimicking Nanozymes for Rapid Detection of Infectious Diseases
Advanced Science, EarlyView.Peroxidase‐mimicking nanozymes (PMNs) have emerged as robust and versatile materials for rapid infectious disease diagnostics. This review highlights the rational design and controlled synthesis of PMNs, summarizes key biomarkers relevant to infectious diseases, examines their integration into diverse rapid detection platforms, and highlights ...
Shikuan Shao +5 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
Proceedings of the International Conference on Applied Innovations in ITTrichomoniasis is the most prevalent non-viral sexually transmitted infection globally, relying on both innate and adaptive immunity to combat the extracellular pathogen Trichomonas vaginalis. This study included 45 infected women and 45 healthy controls
Noor Ghassan +2 more
doaj +1 more source
Lipids in Health and Disease, 2017 Background Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile.
Milena Magalhães Aleluia +13 more
doaj +1 more source
, 2005 We present a semi-analytic treatment of galactic winds within high resolution, large scale cosmological N-body simulations of a LCDM Universe. The evolution of winds is investigated by following the expansion of supernova driven superbubbles around the ...
Adelberger +46 more
core +2 more sources
Advances in Digestive Medicine, EarlyView.Abstract Intestinal ultrasound (IUS) is a non‐invasive imaging method used to evaluate bowel wall inflammation and monitor disease activity in inflammatory bowel disease (IBD) patients. Both the European Crohn's and Colitis Organization and the American Gastroenterological Association endorse IUS for monitoring disease activity and identifying ...
Yu‐Lin Chen +8 more
wiley +1 more source