Results 101 to 110 of about 457,033 (338)

Mapping the Cosmic Web with Ly-alpha Emission

open access: yes, 2003
We use a high-resolution cosmological simulation to predict the distribution of HI Ly-alpha emission from the low-redshift (z10^2 kpc) ``coronae'' of optically thin gas with Ly-alpha surface brightness close to the expected background.
Hogan C. J.   +4 more
core   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo   +12 more
wiley   +1 more source

Hepatocellular carcinoma stem cells: the current state of small molecule-based inhibitors

open access: yesCell Death and Disease
Hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for over 90% of all cases. Patients with advanced-stage HCC are referred to systemic treatment.
Sara P. Neves   +2 more
doaj   +1 more source

Rapid Decline of Zika Virus IgM Antibodies against the NS1 Protein in Imported Israeli Cases [PDF]

open access: bronze, 2022
Yaniv Lustig   +7 more
openalex   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

open access: yesAdvanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong   +6 more
wiley   +1 more source

Radiation Backgrounds at Cosmic Dawn: X-Rays from Compact Binaries

open access: yes, 2017
We compute the expected X-ray diffuse background and radiative feedback on the intergalactic medium (IGM) from X-ray binaries prior and during the epoch of reionization.
Fragos, Tassos, Madau, Piero
core   +2 more sources

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

open access: yesAdvanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He   +11 more
wiley   +1 more source

On the Formation of Warped Gas Disks in Galaxies [PDF]

open access: yes, 2014
We consider the most commonly occurring circumstances which apply to galaxies, namely membership in galaxy groups of about $10^{13}h^{-1} M_\odot$ total mass, and estimate the accompanying physical conditions of intergalactic medium (IGM) density and the
Braun, Robert, Haan, Sebastian
core  

SCCA1–IGM and SCCA2–IGM Compared with Total SCCA-IGM for Diagnosis of Hepatocellular Carcinoma

open access: yesThe International Journal of Biological Markers, 2009
Introduction SCCA1 and SCCA2 belong to the family of serine protease inhibitors (SERPIN). Both SCCA isoforms have been found to be increased in patients with squamous cell carcinoma (SCC) of different organs. Recent findings have demonstrated that SCCA-IgM immune complexes are a novel class of biomarkers for primary liver cancer detection.
BIASIOLO, ALESSANDRA   +6 more
openaire   +2 more sources

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