Results 111 to 120 of about 457,033 (338)

A Rationally Engineered Spleen‐Tropic One‐Component Lipid‐mRNA Complex (OncoLRC) for Cancer Vaccines

Advanced Science, EarlyView.
OncoLRC, a one‐component lipid‐mRNA complex, enables efficient spleen‐targeted delivery at an exceptionally low lipid‐to‐mRNA mass ratio (1.5:1), robustly activates immune responses, inhibits tumor growth, and synergizes with checkpoint blockade, presenting a next‐generation platform for mRNA vaccines.
Qimeng Yin, Chenchen Zhang, Jiahao Li, Kun Huang, Min Qiu   +4 more
wiley   +1 more source

A Structural Basis for the Biochemical Behavior of Activation-induced Deoxycytidine Deaminase Class-switch Recombination-defective Hyper-IgM-2 Mutants [PDF]

, 2012
Yunxiang Mu, Courtney Prochnow, Phuong Pham, Xiaojiang S. Chen, Myron F. Goodman   +4 more
openalex   +1 more source

Self-Consistent Modeling of Reionization in Cosmological Hydrodynamical Simulations

, 2017
The ultraviolet background (UVB) emitted by quasars and galaxies governs the ionization and thermal state of the intergalactic medium (IGM), regulates the formation of high-redshift galaxies, and is thus a key quantity for modeling cosmic reionization ...
Hennawi, Joseph F, Lukić, Zarija, Oñorbe, Jose   +2 more
core   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia

Lipids in Health and Disease, 2017
Background Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has been also associated to alterations in the lipid profile.
Milena Magalhães Aleluia, Caroline Conceição da Guarda, Rayra Pereira Santiago, Teresa Cristina Cardoso Fonseca, Fábia Idalina Neves, Regiana Quinto de Souza, Larissa Alves Farias, Felipe Araújo Pimenta, Luciana Magalhães Fiuza, Thassila Nogueira Pitanga, Júnia Raquel Dutra Ferreira, Elisângela Vitória Adorno, Bruno Antônio Veloso Cerqueira, Marilda de Souza Gonçalves   +13 more
doaj   +1 more source

Detection of Toxoplasma gondii IgM and Cytomegalovirus IgM antibodies among blood donors in Mosul [PDF]

, 2011
Karam A. Al-Dabbagh
openalex   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

P1276: DOSE RESPONSE PROFILE OF IGM-2323, A CD20XCD3 IGM BISPECIFIC T CELL ENGAGER, IN TRANSLATIONAL MODELS SUPPORTS PHASE 2 DOSE SELECTION IN NON-HODGKIN’S LYMPHOMA

HemaSphere, 2022
M. K. Leabman, G. Hernandez, C. M. Ng, J. Tang, D. Pandya, K. C. Hart, K. Li, P. R. Hinton, J. So, I. Qazi, C. Y. Cheah, W. S. Kim, E. Budde, A. K. Gopal, T. Manley, C. H. Takimoto, A. M. Sinclair, S. F. Carroll, B. A. Keyt, M. F. Kotturi   +19 more
doaj   +1 more source

μRNA E PROGNÓSTICO DO MIELOMA MÚLTIPLO: DADOS DE REVISÃO SISTEMÁTICA

Hematology, Transfusion and Cell Therapy
Objetivo: O presente estudo teve como objetivo realizar uma revisão sistemática visando estimar a influência de μRNAs no prognóstico do Mieloma Múltiplo (MM) e sua correlação com biomarcadores já padronizados ou com biomoléculas já conhecidas na ...
NJ Nazareth, CA Fonseca, MSM Silveira, MS Gonçalves   +3 more
doaj   +1 more source

Single‐Cell Profiling Across Immune Tissues and Organs Reveals Immunosenescence Signatures in Male Rhesus Monkeys

Advanced Science, EarlyView.
Single‐cell profiling across bone marrow, spleen, mesenteric lymph, and blood in rhesus monkeys reveals organ Immunosenescence. GZMB rises with age, particularly in cytotoxic and terminally exhausted CD8+ T cells, and BHLHE40 emerges as a key transcription factor enriched across multiple CD8+ subsets, regulating pro‐inflammatory and exhaustion‐related ...
Shengnan Wang, Zhengna Zhu, Hongju Yang, Yaping Yan, Luyao Ran, Naixue Yang, Yichao Wang, Li Wu, Bing Bai, Weizhi Ji, Wei Si   +10 more
wiley   +1 more source