Results 11 to 20 of about 457,033 (338)
Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells
Redox Biology, 2023 Acute myeloid leukemia (AML) is a very heterogeneous group of disorders with large differences in the percentage of immature blasts that presently are classified according to the specific mutations that trigger malignant proliferation among thousands of ...
Rafaela G.A. Costa +6 more
doaj +1 more source
Frontiers in Immunology, 2020 The excessive release of heme during hemolysis contributes to the severity of sickle cell anemia (SCA) by exacerbating hemoglobin S (HbS) autoxidation, inflammation and systemic tissue damage. The present study investigated the effect of hydroxyurea (HU)
Sânzio Silva Santana +13 more
doaj +1 more source
Constraint on intergalactic dust from thermal history of intergalactic medium [PDF]
, 2002 This Letter investigates the amount of dust in the intergalactic medium (IGM). The dust photoelectric heating can be the most efficient heating mechanism in the IGM where the density is very small and there are a lot of hard ultraviolet photons ...
Inoue, Akio K., Kamaya, Hideyuki
core +2 more sources
The contribution of the IGM and minihalos to the 21 cm signal of reionization [PDF]
, 2009 We study the statistical properties of the cosmological 21 cm signal from both the intergalactic medium (IGM) and minihalos, using a reionization simulation that includes a self--consistent treatment of minihalo photoevaporation.
Ahn +73 more
core +1 more source
Journal of Experimental Medicine, 2018 In this issue of JEM, Thierry et al. (https://doi.org/10.1084/jem.20180344) demonstrate that, once secreted by freshly activated plasmablasts, IgM leaves the lymph node via the microarchitecture of the fibroblastic reticular cell conduit. This work demonstrates how the very peculiar stromal compartment of lymphatic organs optimizes the systemic ...
Anne Reversat, Michael Sixt
openaire +2 more sources
Structure, Function, and Therapeutic Use of IgM Antibodies
Antibodies, 2020 Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to ...
Bruce A. Keyt +4 more
doaj +1 more source
Biomolecules, 2022 Oxidative stress plays a central role in the pathophysiology of melanoma. Curcumin (CUR) is a polyphenolic phytochemical that stimulates reactive oxygen species (ROS) production, while disulfiram (DSS) is a US FDA-approved drug for the treatment of ...
Sheila S. Fontes +6 more
doaj +1 more source
Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies [PDF]
, 2006 Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental pathology by adhering to host receptors such as chondroitin sulphate A (CSA ...
Ahmed Raza +37 more
core +1 more source
Annals of Hepatology, 2023 Introduction and Objectives: Hepatitis E is a neglected disease in Brazil. Hepatitis E virus (HEV) can cause chronic illness in immunocompromised patients.
Luan Henrique Paim Santos +16 more
doaj +1 more source
Future Evolution of the Intergalactic Medium in a Universe Dominated by a Cosmological Constant [PDF]
, 2004 We simulate the evolution of the intergalactic medium (IGM) in a universe dominated by a cosmological constant. We find that within a few Hubble times from the present epoch, the baryons will have two primary phases: one phase composed of low-density ...
Abraham Loeb +34 more
core +1 more source