Results 11 to 20 of about 427,117 (288)

Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells

Redox Biology, 2023
Acute myeloid leukemia (AML) is a very heterogeneous group of disorders with large differences in the percentage of immature blasts that presently are classified according to the specific mutations that trigger malignant proliferation among thousands of ...
Rafaela G.A. Costa, Suellen L.R. Silva, Ingrid R.S.B. Dias, Maiara de S. Oliveira, Ana Carolina B. da C. Rodrigues, Rosane B. Dias, Daniel P. Bezerra   +6 more
doaj   +1 more source

Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor induced growth arrest and apoptosis through NF-κB activation [PDF]

, 2013
Kaposi's sarcoma-associated herpesvirus (KSHV) has been linked to the development of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease (MCD). We have characterized the role of KSHV-encoded viral FLICE inhibitory protein K13
Ahmad, B. Tolani, Ballon, Benhamou, Bower, Bren, C. Graham, Chang, Chaudhary, Chugh, Delmore, Dong, Du, Dupin, Dupin, Eeva, Eeva, Field, Gerondakis, Guasparri, H. Matta, H. Yi, Hassman, Herzog, Lee, Liu, Madureira, Matta, Matta, Matta, Matta, Mineva, Nador, Niiro, P. M. Chaudhary, Parravicini, Punj, Schauer, Soulier, Sun, Sun, Sun, Thome, Vrzalikova, Waterston, Wu, Wu, Wu, Y. Suo, Y. Yang, Yang, Yang, Young, Zhao   +53 more
core   +1 more source

IgM’s exit route [PDF]

Journal of Experimental Medicine, 2018
In this issue of JEM, Thierry et al. (https://doi.org/10.1084/jem.20180344) demonstrate that, once secreted by freshly activated plasmablasts, IgM leaves the lymph node via the microarchitecture of the fibroblastic reticular cell conduit. This work demonstrates how the very peculiar stromal compartment of lymphatic organs optimizes the systemic ...
Anne Reversat, Michael Sixt
openaire   +2 more sources

Structure, Function, and Therapeutic Use of IgM Antibodies

Antibodies, 2020
Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure to ...
Bruce A. Keyt, Ramesh Baliga, Angus M. Sinclair, Stephen F. Carroll, Marvin S. Peterson   +4 more
doaj   +1 more source

The contribution of the IGM and minihalos to the 21 cm signal of reionization [PDF]

, 2009
We study the statistical properties of the cosmological 21 cm signal from both the intergalactic medium (IGM) and minihalos, using a reionization simulation that includes a self--consistent treatment of minihalo photoevaporation.
Ahn, Ali, Barkana, Benedetta Ciardi, Bin Yue, Chen, Chen, Chuzhoy, Chuzhoy, Ciardi, Ciardi, Ciardi, Ciardi, Ciardi, Ciardi, Ciardi, Cooray, Efstathiou, Evan Scannapieco, Field, Furlanetto, Furlanetto, Furlanetto, Furlanetto, Furlanetto, Furlanetto, Furlanetto, Haiman, He, Hockney, Iliev, Iliev, Iliev, Iliev, Kauffmann, Kramer, Kuhlen, Lacey, Lewis, Loeb, Madau, Mao, Maselli, Maselli, Meiksin, Mellema, Miniati, Mo, Navarro, Nusser, Oh, Oh, Oh, Pillepich, Pritchard, Ripamonti, Rybicki, Santos, Santos, Seager, Seager, Semelin, Shapiro, Shapiro, Shapiro, Shapiro, Shapiro, Sheth, Tozzi, Whalen, Wouthuysen, Xuelei Chen, Yoshida, Zaldarriaga   +73 more
core   +1 more source

Heating of the IGM [PDF]

, 1998
Using the cosmic virial theorem, Press-Schechter analysis and numerical simulations, we compute the expected X-ray background (XRB) from the diffuse IGM with the clumping factor expected from gravitational shock heating.
Cooray A., Eke V. R., Hasinger G., Jain B., Miyaji T., Navarro J. F.   +5 more
core   +3 more sources

Identification of Plasmodium falciparum var1CSA and var2CSA domains that bind IgM natural antibodies [PDF]

, 2006
Malaria in pregnancy is responsible for maternal anaemia, low-birth-weight babies and infant deaths. Plasmodium falciparum infected erythrocytes are thought to cause placental pathology by adhering to host receptors such as chondroitin sulphate A (CSA ...
Ahmed Raza, Atalay, Baruch, Baruch, Buffet, Chen, Chen, Chitnis, Cohen, Cooke, Craig, Creasey, Fagan, Flick, Fried, Gamain, Gamain, Gardner, Guyatt, J. Alexandra Rowe, Jean-Philippe Semblat, Kyes, Kyes, Langone, Lin, Mayor, Medina, Medina, Rowe, Rowe, Rowe, Salanti, Salanti, Scholander, Smith, Smith, Su, Sue A. Kyes   +37 more
core   +1 more source

Pediatric Selective IgM Immunodeficiency [PDF]

Clinical and Developmental Immunology, 2008
Objective. Limited information exists on features of pediatric Selective IgM immunodeficiency (SIgMID). Previously published pediatric cases and 2 new cases are reviewed.Methods. English literature from PubMed and references from relevant articles were reviewed. Previously reported cases and 2 new cases from an allergy/immunology practice were analyzed.
Marc F. Goldstein, Alex L. Goldstein, Eliot H. Dunsky, Donald J. Dvorin, George A. Belecanech, Kfir Shamir   +5 more
openaire   +3 more sources

Kinetics of IgM, IgA, IgG to SARS-CoV-2 in children with COVID-19 in Lviv region in different periods of the infectious process depending on the severity of the course and age

Acta Medica Leopoliensia, 2023
Aim. The research aims at analyzing the kinetics of IgA, IgM, and IgG to SARS-CoV-2 in children based on the severity of COVID-19 and age. Materials and Methods.
Maria Stasiv
doaj   +1 more source

Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells

Cell Death and Disease, 2023
Females have a lower probability to develop somatic cancers and a better response to chemotherapy than males. However, the reasons for these differences are still not well understood.
Miriana Cardano, Martina Magni, Roberta Alfieri, Siu Yuen Chan, Simone Sabbioneda, Giacomo Buscemi, Laura Zannini   +6 more
doaj   +1 more source