Results 41 to 50 of about 427,117 (288)

Ruthenium Complexes Containing Heterocyclic Thioamidates Trigger Caspase-Mediated Apoptosis Through MAPK Signaling in Human Hepatocellular Carcinoma Cells

open access: yesFrontiers in Oncology, 2019
Herein, ruthenium complexes containing heterocyclic thioamidates [Ru(mmi)(bipy)(dppb)]PF6 (1), [Ru(tzdt)(bipy)(dppb)]PF6 (2), [Ru(dmp)(bipy)(dppb)]PF6 (3) and [Ru(mpca)(bipy)(dppb)]PF6 (4) were investigated for their cellular and molecular effects in ...
Sara P. Neves   +10 more
doaj   +1 more source

Measurement of the small-scale structure of the intergalactic medium using close quasar pairs

open access: yes, 2017
The distribution of diffuse gas in the intergalactic medium (IGM) imprints a series of hydrogen absorption lines on the spectra of distant background quasars known as the Lyman-$\alpha$ forest.
Hennawi, Joseph F.   +8 more
core   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer   +3 more
wiley   +1 more source

PLEIOTROPIC EFFECT OF POLYMORPHISMS IN THE BCL11A GENE IN INDIVIDUALS WITH SICKLE CELL ANEMIA

open access: yesHematology, Transfusion and Cell Therapy, 2023
Sickle cell anemia (SCA) is one of the types of sickle cell disease (SCD), which is characterized by hematological events such as hemolysis and endothelial damage that culminate in vaso-occlusion, leading to the appearance of several clinical ...
AMJ Oliveira   +8 more
doaj   +1 more source

Evidence for somatic selection of natural autoantibodies. [PDF]

open access: yes, 1992
Natural autoantibodies are primarily immunoglobulin M (IgM) antibodies that bind to a variety of self-antigens, including self-IgG. Accounting for a large proportion of the early B cell repertoire, such polyspecific autoantibodies are speculated to ...
Carson, DA   +3 more
core  

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

open access: yesArthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner   +14 more
wiley   +1 more source

Ethical Work Climate Untuk Menciptakan Moral Awareness Karyawan Pada Koperasi Bank Perkreditan Rakyat Tribakti Nganjuk

open access: yesJurnal Manajemen Teori dan Terapan, 2016
This study would examined empirically which one of these ethical criteria, namely self-interest, company, interest, efficiency, friendship, team play, social responsibility, personal morality, rules and procedures, and the law or professional code ...
Siti Sulasmi, IGM Dwi Widhianto
doaj   +1 more source

ESTUDO INTEGRADO DA HEPATITE E EM SALVADOR-BA

open access: yesBrazilian Journal of Infectious Diseases, 2022
Introdução/Objetivo: A hepatite E é uma doença negligenciada no Brasil. O HEV pode ser transmitido pela via fecal-oral, sanguínea e zoonótica a partir principalmente de suínos, e pode ocasionar doença crônica em pacientes imunocomprometidos.
Daniela Santana Mendes   +19 more
doaj   +1 more source

Diagnostic Use of Testing for Novel Murine Autoantibodies for Sjögren Disease in the Rheumatology Outpatient Setting

open access: yesArthritis Care &Research, EarlyView.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr   +5 more
wiley   +1 more source

The Ionizing Efficiency of the First Stars [PDF]

open access: yes, 2003
We investigate whether a single population of first stars could have influenced both the metal enrichment and reionization of the high-redshift intergalactic medium (IGM), by calculating the generated ionizing radiation per unit metal yield as a function
Truran, James W., Venkatesan, Aparna
core   +3 more sources

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