Results 51 to 60 of about 215,830 (266)

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

SSR4 sustains Tertiary Lymphoid Structures by Regulation Quality Control of N‐linked Glycosylation During B‐cell Differentiation Into Plasmacyte in Colorectal Cancer

Advanced Science, EarlyView.
SSR4, a TRAP component induced in B cells, governs BAFFR N‐glycosylation via DDOST to sustain NF‐κB signaling, B‐cell differentiation, and TLS maturation. Its loss impairs anti‐tumor immunity, while overexpression improves antibody glycosylation and ADCC, revealing a critical regulator for cancer immunotherapy.
Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma, Xiaobing Yang, Bin Wang, Yuan Fang, Lulu Yang, Yelin Zhao, Shuli Zhao   +15 more
wiley   +1 more source

Hedgehog components are overexpressed in a series of liver cancer cases

Scientific Reports
Liver cancers, including hepatocellular carcinoma (HCC), are the sixth most common cancer and the third leading cause of cancer-related death worldwide, representing a global public health problem. This study evaluated nine patients with HCC.
Caroline Brandi Schlaepfer Sales, Rosane Borges Dias, Ludmila de Faro Valverde, Larissa M. Bomfim, Lais Almeida Silva, Nanashara C. de Carvalho, Jorge Luiz Andrade Bastos, Tatiana Martins Tilli, Gisele Vieira Rocha, Milena Botelho Pereira Soares, Luiz Antonio Rodrigues de Freitas, Clarissa A. Gurgel Rocha, Daniel P. Bezerra   +12 more
doaj   +1 more source

IgM Myeloma: An IgM Gammopathy Distinct from Waldenstrom's Macroglobulinemia [PDF]

Hematology, 2001
A 65-year-old patient with an IgM gammopathy, plasma cell infiltration of the bone marrow, lytic lesions of the skeleton, and symptoms of hyperviscosity was evaluated. A diagnosis of IgM myeloma was made. Treatment for multiple myeloma was initiated and resulted in a significant clinical response. There is ongoing debate whether IgM myeloma exists as a
L T, Nordquist, H I, Saba, L C, Moscinski   +2 more
openaire   +2 more sources

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung

Advanced Science, EarlyView.
Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu, Saiya Li, Guodong Wu, Shuangjian Li, Long Shuang Huang, Xiaoyang Li, Yiguo Zhao, Wei Lu, Cuixia Sun, Qin Cao, Yapeng Fang, Yiping Cao   +11 more
wiley   +1 more source

PERCEPTION OF USEFULNESS AND EASE OF INTEREST IN USING SHARIA FINTECH

I-Finance
The aim of the research is to analyze perceptions of usefulness and ease of use fintech sharia among S2 STEBIS IGM Palembang students. The population in this study were STEBIS IGM students with a total research population of 314 students and female ...
Amir Salim, Eva Susanti, Doly Nofiansyah
doaj   +1 more source

Toxoplasmosis in thalassemic Iraqi patients: serological and hematological study [PDF]

Romanian Journal of Infectious Diseases
Background. Toxoplasmosis is a zoonotic parasitic disease with high prevalence, caused by an obligate intracellular parasite Toxoplasma gondii. Thalassemia is an inherited blood disorder in which the body makes an atypical form or insufficient amount of ...
Raghad N. Shihab, Israa Kasim Al-Aubaidi
doaj   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

EARLY DETECTION AND EPIDEMIOLOGICAL PROFILE OF OROPOUCHE FEVER IN SALVADOR-BA

Brazilian Journal of Infectious Diseases
Introduction/Objectives: Oropouche fever, caused by the Oropouche virus (OROV), is an arboviral disease with sylvatic and urban cycles endemic to the Amazon region. Transmission occurs through the biting midge Culicoides paraensis. Symptoms include fever,
Adryele Figueiredo Pinheiro, Fernanda Lopes Habib, Marcos Silva Brito, Davi Bastos Lemos, Maria Paula Sampaio, Natalie Nascimento Oliveira, Joilson de Gusmao Guimaraes, Ively Paixão Santos, Gubio Soares Campos, Isadora Cristina de Siqueira   +9 more
doaj   +1 more source