Results 51 to 60 of about 235,216 (254)

A novel platform for isotype-specific testing of autoantibodies. [PDF]

, 2019
The objective of this study was to test if a novel platform could be used for isotype-specific autoantibody testing in humans. Further, we evaluated if testing with this novel platform enables earlier detection of insulin autoantibodies in individuals ...
Carter, Kaylene L, Davis, Kara L, Feldman, Brian J, Kumar, Rajiv B, Treurnicht, Anckia   +4 more
core   +2 more sources

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Measurement of the small-scale structure of the intergalactic medium using close quasar pairs

, 2017
The distribution of diffuse gas in the intergalactic medium (IGM) imprints a series of hydrogen absorption lines on the spectra of distant background quasars known as the Lyman-$\alpha$ forest.
Hennawi, Joseph F., Kulkarni, Girish, Lee, Khee-Gan, Lukić, Zarija, Oñorbe, Jose, Prochaska, J. Xavier, Rorai, Alberto, Walther, Michael, White, Martin   +8 more
core   +1 more source

Diagnostic Use of Testing for Novel Murine Autoantibodies for Sjögren Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, EarlyView.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model

Frontiers in Oncology, 2019
Ruthenium complexes with piplartine, [Ru(piplartine)(dppf)(bipy)](PF6)2 (1) and [Ru(piplartine)(dppb)(bipy)](PF6)2 (2) (dppf = 1,1-bis(diphenylphosphino) ferrocene; dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine), were recently ...
Ingrid R. S. Baliza, Suellen L. R. Silva, Luciano de S. Santos, João H. Araujo Neto, Rosane B. Dias, Caroline B. S. Sales, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Alzir A. Batista, Daniel P. Bezerra   +9 more
doaj   +1 more source

Toxoplasma gondii Recombinant antigen AMA1: Diagnostic Utility of Protein Fragments for the Detection of IgG and IgM Antibodies

Pathogens, 2020
Toxoplasma gondii is an important zoonotic protozoan that infects a wide variety of vertebrates as intermediate hosts. For this reason, the diagnosis of this disease is very important and requires continuous improvement.
Bartłomiej Ferra, Lucyna Holec-Gąsior, Justyna Gatkowska, Bożena Dziadek, Katarzyna Dzitko   +4 more
doaj   +1 more source

Preheating of the Universe by cosmic rays from primordial supernovae at the beginning of cosmic reionization

, 2015
The 21-cm signal from the cosmic reionization epoch can shed light on the history of heating of the primordial intergalactic medium (IGM) at z~30-10.
Sazonov, Sergey, Sunyaev, Rashid
core   +1 more source

Mass loss from galaxies: feeding the IGM, recycling in the IGM [PDF]

Astrophysics and Space Science, 2002
4 pages, 3 figures, in "The Evolution of Galaxies.II. Basic Building Blocks", M. Sauvage, G. Stasinska, L. Vigroux, D. Schaerer, S.
Duc, Pierre-Alain, Braine, Jonathan, Lisenfeld, Ute, Amram, Philippe, Brinks, Elias   +4 more
openaire   +2 more sources

Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis–Associated Interstitial Lung Disease Risk

Arthritis Care &Research, EarlyView.
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase‐7 (MMP‐7), and serum anti–malondialdehyde‐acetaldehyde (anti‐MAA) antibody for rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) risk stratification.
Kelsey Coziahr, Austin M. Wheeler, Brent A. Luedders, Michael Duryee, Halie Frideres, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Dana P. Ascherman, Paul A. Monach, Gail S. Kerr, Andreas M. Reimold, Scott M. Matson, Joshua F. Baker, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +16 more
wiley   +1 more source

Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells

Cell Death Discovery
Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effective control
Suellen L. R. Silva, Ingrid R. S. B. Dias, Ana Carolina B. da C. Rodrigues, Rafaela G. A. Costa, Maiara de S. Oliveira, Gabriela A. da C. Barbosa, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Nainita Roy, Christopher Y. Park, Daniel P. Bezerra   +12 more
doaj   +1 more source