Results 51 to 60 of about 427,117 (288)

Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis–Associated Interstitial Lung Disease Risk

Arthritis Care &Research, EarlyView.
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase‐7 (MMP‐7), and serum anti–malondialdehyde‐acetaldehyde (anti‐MAA) antibody for rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) risk stratification.
Kelsey Coziahr, Austin M. Wheeler, Brent A. Luedders, Michael Duryee, Halie Frideres, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Dana P. Ascherman, Paul A. Monach, Gail S. Kerr, Andreas M. Reimold, Scott M. Matson, Joshua F. Baker, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +16 more
wiley   +1 more source

Ruthenium Complexes With Piplartine Cause Apoptosis Through MAPK Signaling by a p53-Dependent Pathway in Human Colon Carcinoma Cells and Inhibit Tumor Development in a Xenograft Model

Frontiers in Oncology, 2019
Ruthenium complexes with piplartine, [Ru(piplartine)(dppf)(bipy)](PF6)2 (1) and [Ru(piplartine)(dppb)(bipy)](PF6)2 (2) (dppf = 1,1-bis(diphenylphosphino) ferrocene; dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2′-bipyridine), were recently ...
Ingrid R. S. Baliza, Suellen L. R. Silva, Luciano de S. Santos, João H. Araujo Neto, Rosane B. Dias, Caroline B. S. Sales, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Alzir A. Batista, Daniel P. Bezerra   +9 more
doaj   +1 more source

Effect of Intergalactic Medium on the Observability of Lyman Alpha Emitters during Cosmic Reionization

, 2012
We perform a systematic study of how the inhomogeneities in the Inter-Galactic Medium (IGM) affect the observability of Lyman Alpha Emitters (LAEs) around the Epoch of Reionization.
Adams, Akila Jeeson-Daniel, Antonella Maselli, Barkana, Barnes, Benedetta Ciardi, Bland-Hawthorn, Bolton, Bromm, Cantalupo, Cassata, Charlot, Ciardi, Ciardi, Clarke, Clément, Davis, Davis, Davé, Dawson, Dayal, Dijkstra, Dijkstra, Dijkstra, Dijkstra, Dijkstra, Dijkstra, Dijkstra, Djorgovski, Dove, Eisenstein, Forero-Romero, Fujita, Furlanetto, Gnedin, Gronwall, Guaita, Gunn, Haiman, Haiman, Hartmann, Hill, Hu, Iliev, Iwata, Iye, Kashikawa, Kobayashi, Kobayashi, Kollmeier, Laursen, Laursen, Laursen, Le Delliou, Le Delliou, Lehnert, Leitherer, Loeb, Maio, Maio, Maio, Malhotra, Malhotra, Malhotra, Marco Pierleoni, Mark Dijkstra, Maselli, Maselli, McQuinn, Meier, Mesinger, Mesinger, Miralda Escude, Nagamine, Neufeld, Nilsson, Nilsson, Ono, Ouchi, Ouchi, Ouchi, Paardekooper, Partridge, Partridge, Pentericci, Pierleoni, Pritchard, Razoumov, Rhoads, Rhoads, Ricotti, Samui, Santoro, Santos, Schaerer, Schaerer, Schenker, Schneider, Schneider, Shapley, Siana, Springel, Steidel, Steidel, Taniguchi, Tasitsiomi, Tilvi, Tilvi, Tornatore, Trenti, Umberto Maio, Valls-Gabaud, Verhamme, Verhamme, Wang, Wise, Wolf, Wood, Wyithe, Wyithe, Yajima, Yajima, Yoshida, Zheng, Zheng   +124 more
core   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells

Cell Death Discovery
Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote the development and progression of AML, and eradication of LSCs is critical for effective control
Suellen L. R. Silva, Ingrid R. S. B. Dias, Ana Carolina B. da C. Rodrigues, Rafaela G. A. Costa, Maiara de S. Oliveira, Gabriela A. da C. Barbosa, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. G. Rocha, Nainita Roy, Christopher Y. Park, Daniel P. Bezerra   +12 more
doaj   +1 more source

Lipids: Evergreen autofluorescent biomarkers for the liver functional profiling

European Journal of Histochemistry, 2017
Depending on their chemical nature, lipids can be classified in two main categories: hydrophilic, greatly contributing to membrane composition and subcellular organelle compartmentalization, and hydrophobic, mostly triglycerides, greatly enrolled in the ...
Anna Cleta Croce, Giovanni Bottiroli
doaj   +1 more source

Toxoplasma gondii Recombinant antigen AMA1: Diagnostic Utility of Protein Fragments for the Detection of IgG and IgM Antibodies

Pathogens, 2020
Toxoplasma gondii is an important zoonotic protozoan that infects a wide variety of vertebrates as intermediate hosts. For this reason, the diagnosis of this disease is very important and requires continuous improvement.
Bartłomiej Ferra, Lucyna Holec-Gąsior, Justyna Gatkowska, Bożena Dziadek, Katarzyna Dzitko   +4 more
doaj   +1 more source

Primordial Galaxy Formation and IGM Reionization

, 2001
In this talk I will present a model for primordial galaxy formation. In particular, I will review the feedback effects that regulate the process: (i) radiative (i.e. ionizing and H_2-photodissociating photons) and (ii) stellar (i.e.
Ciardi, Benedetta
core   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis

Cell Death Discovery
Acute myeloid leukaemia (AML) is a lethal bone marrow neoplasm caused by genetic alterations in blood cell progenitors. Leukaemic stem cells (LSCs) are responsible for the development of AML, drug resistance and relapse.
Ingrid R. S. B. Dias, Rafaela G. A. Costa, Ana Carolina B. da C. Rodrigues, Suellen L. R. Silva, Maiara de S. Oliveira, Milena B. P. Soares, Rosane B. Dias, Ludmila F. Valverde, Clarissa A. Gurgel Rocha, Lauren V. Cairns, Ken I. Mills, Daniel P. Bezerra   +11 more
doaj   +1 more source