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A turn for the worse: Aβ β-hairpins in Alzheimer's disease. [PDF]
Bioorg Med ChemRuttenberg SM, Nowick JS.
europepmc +1 more source
Difficult-to-express shark IgNAR antibody produced in CHO cells: production bottleneck identification and a trial for productivity enhancementopenaire
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IgNAR antibody: Structural features, diversity and applications
Fish and Shellfish Immunology, 2022In response to the invasion of exogenous microorganisms, one of the defence strategies of the immune system is to produce antibodies. Cartilaginous fish is among those who evolved the earliest humoral immune system that utilizes immunoglobulin-type antibodies. The cartilaginous fish antibodies fall into three categories: IgW, IgM, and IgNAR.
Hylemariam Mihiretie Mengist +2 more
exaly +3 more sources
Fish and Shellfish Immunology, 2023
Single domain antibodies (sdAb) are promising candidates in cancer and anti-virus biotherapies for their unique structure characters. Though VHH and IgNAR have been discovered in camelidae and nurse shark (Ginlymostoma cirratum) respectively serval decades ago, expense of these large animals still limits the studies and applications of sdAb.
bo zhong, Guodong Chen, Xiaofeng Jiang
exaly +3 more sources
Single domain antibodies (sdAb) are promising candidates in cancer and anti-virus biotherapies for their unique structure characters. Though VHH and IgNAR have been discovered in camelidae and nurse shark (Ginlymostoma cirratum) respectively serval decades ago, expense of these large animals still limits the studies and applications of sdAb.
bo zhong, Guodong Chen, Xiaofeng Jiang
exaly +3 more sources
Sequence structure character of IgNAR Sec in whitespotted bamboo shark (Chiloscyllium plagiosum)
Fish and Shellfish Immunology, 2020Whitespotted bamboo shark (Chiloscyllium plagiosum) is a demersal cartilaginous fish with an adaptive immune system founded upon immunoglobulins. In this manuscript, we characterize the IgNAR of the whitespotted bamboo shark. A newly discovered alternative splicing form of IgNAR Sec (IgNARshort (ΔC2-C3) Sec) was identified, in which the C1 domain was ...
Guiqian Chen +2 more
exaly +3 more sources
Dimerisation strategies for shark IgNAR single domain antibody fragments
Journal of Immunological Methods, 2006Immunoglobulin new antigen receptors (IgNARs) are unique single domain antibodies found in the serum of sharks. The individual variable (VNAR) domains bind antigen independently and are candidates for the smallest antibody-based immune recognition units (approximately 13 kDa).
Victor A Streltsov
exaly +3 more sources
Selection of cholera toxin specific IgNAR single-domain antibodies from a naïve shark library
Molecular Immunology, 2007Shark immunoglobulin new antigen receptor (IgNAR, also referred to as NAR) variable domains (Vs) are single-domain antibody (sdAb) fragments containing only two hypervariable loop structures forming 3D topologies for a wide range of antigen recognition and binding. Their small size ( approximately 12kDa) and high solubility, thermostability and binding
George P Anderson, Andrew Hayhurst
exaly +3 more sources
Journal of Molecular Biology, 2010
The shark antigen-binding V(NAR) domain has the potential to provide an attractive alternative to traditional biotherapeutics based on its small size, advantageous physiochemical properties, and unusual ability to target clefts in enzymes or cell surface molecules. The V(NAR) shares many of the properties of the well-characterised single-domain camelid
B J, Fennell +9 more
openaire +2 more sources
The shark antigen-binding V(NAR) domain has the potential to provide an attractive alternative to traditional biotherapeutics based on its small size, advantageous physiochemical properties, and unusual ability to target clefts in enzymes or cell surface molecules. The V(NAR) shares many of the properties of the well-characterised single-domain camelid
B J, Fennell +9 more
openaire +2 more sources
Cas9-Based Local Enrichment and Genomics Sequence Revision of Megabase-Sized Shark IgNAR Loci
The Journal of Immunology, 2022Abstract The 0.8-Mb Ig new Ag receptor (IgNAR) region of the whitespotted bamboo shark (Chiloscyllium plagiosum) is incompletely assembled in Chr_44 of the reference genome. Here we used Cas9-assisted targeting of chromosome segments (CATCH) to enrich the 2 Mb region of the Chr_44 IgNAR loci and sequenced it by PacBio and next-generation
Hongming Dong +14 more
openaire +2 more sources