Results 61 to 70 of about 4,347 (168)

Nanoparticle‐Based Bioaffinity Assays: From the Research Laboratory to the Market

Advanced Materials, Volume 36, Issue 3, January 18, 2024.
This review critically discusses advances in nanoparticle‐based labels (yellow) combined with biorecognition elements (green) and suitable readout schemes for the design of new bioaffinity assays. The route of nanoparticle‐based assays from the bench to real sample analysis and commercialization follows a rugged path winding between many challenges and
Zdeněk Farka, Julian C. Brandmeier, Matthias J. Mickert, Matěj Pastucha, Karel Lacina, Petr Skládal, Tero Soukka, Hans H. Gorris   +7 more
wiley   +1 more source

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain

, 2016
The vast majority of clinically-approved protein kinase inhibitors target the ATP binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects.
Bayliss, R, Burgess, SG, Cavazza, T, Matthews, D, Oleksy, A, Richards, MW, Vernos, I   +6 more
core   +1 more source

Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody

Virology, 2011
The Hepatitis B virus precore protein is processed in the endoplasmic reticulum (ER) into secreted hepatitis B e antigen (HBeAg), which acts as an immune tolerogen to establish chronic infection. Downregulation of secreted HBeAg should improve clinical outcome, as patients who effectively respond to current treatments (IFN-α) have significantly lower ...
Walsh, Renae, Nuttall, Stewart, Revill, Peter, Colledge, Danni, Cabuang, Liza, Soppe, Sally, Dolezal, Olan, Griffiths, Kate, Bartholomeusz, Angeline, Locarnini, Stephen   +9 more
openaire   +2 more sources

Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance [PDF]

, 2017
Although chemotherapy is designed to eradicate tumor cells, it also has significant effects on normal tissues. The platinum-induced fatty acid 16:4(n-3) (hexadeca-4,7,10,13-tetraenoic acid) induces systemic resistance to a broad range of DNA-damaging ...
Daenen, Laura G.M., Hansen, Steffen V.F., Hirasawa, Akira, Houthuijzen, Julia M., Hudson, Brian D., Ishihara, Kenji, Jaarsveld, Marijn T.M., McLean, Chelsea M., Milligan, Graeme, Oosterom, Ilse, Peeper, Daniel S., Roodhart, Jeanine M.L., Sadatmand, Sahar Jafari, Ulven, Trond, van de Lest, Chris H.A., Voest, Emile E.   +15 more
core   +3 more sources

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis [PDF]

Journal of Biological Chemistry, 2013
The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the shark immune system that exist as heavy chain-only homodimers and bind antigens by their single domain variable regions (V-NARs). Following shark immunization and/or in vitro selection, V-NARs can be generated as soluble, stable, and specific high affinity ...
Oleg V, Kovalenko, Andrea, Olland, Nicole, Piché-Nicholas, Adarsh, Godbole, Daniel, King, Kristine, Svenson, Valerie, Calabro, Mischa R, Müller, Caroline J, Barelle, William, Somers, Davinder S, Gill, Lidia, Mosyak, Lioudmila, Tchistiakova   +12 more
openaire   +2 more sources

The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) [PDF]

, 2014
The long-chain fatty acid receptor FFA4(previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease.
Hudson, Brian D., Milligan, Graeme, Shimpukade, Bharat, Ulven, Trond   +3 more
core   +1 more source

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver [PDF]

, 2012
Peer reviewedPublisher ...
A Everard, A M Neyrinck, AJ Brown, AS Neish, BF Hinnebusch, BL Pool-Zobel, C Cherbut, C Daubioul, C Sundstrom, E Le Poul, E M Dewulf, F Guarner, G G Muccioli, G Tolhurst, HS Taper, J Bray, J Busserolles, J C Martin, J Verrax, K P Scott, KM Maslowski, L B Bindels, LB Bindels, M Aoyama, M Montillo, MA Cox, MA Vinolo, N M Delzenne, NG Kondegowda, O Feron, P Buc Calderon, P D Cani, P Louis, P Porporato, P Sonveaux, P Sonveaux, PD Cani, PD Cani, R Alric, R Ren, S Siavoshian, T Lee, W Fiskus, Y Tang, Y Tang, Y Wang, YH Hong   +46 more
core   +1 more source

Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications

International Journal of Nanomedicine, 2016
Yongzhong Wang,1 Zhen Fan,2 Lei Shao,3 Xiaowei Kong,1 Xianjuan Hou,1 Dongrui Tian,1 Ying Sun,1 Yazhong Xiao,1 Li Yu4 1School of Life Sciences, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei, People’s Republic of
Wang Y, Fan Z, Shao L, Kong X, Hou X, Tian D, Sun Y, Xiao Y, Yu L   +8 more
doaj  

Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling [PDF]

, 2017
Signaling pathways can be linear, but more complex patterns are common. Growth factors and many other extracellular signals cannot directly enter cells and transduce their information via membrane-bound receptors.
Picard, D.
core  

Systemic availability and metabolism of colonic-derived short-chain fatty acids in healthy subjects: a stable isotope study [PDF]

, 2016
The short-chain fatty acids (SCFAs), acetate, propionate and butyrate, are bacterial metabolites that mediate the interaction between the diet, the microbiota and the host.
Annaert, Pieter, Boets, Eef, Courtin, Christophe M., De Preter, Vicky, De Vuyst, Luc, Delcour, Jan A., Deroover, Lise, Gomand, Sara V., Hamer, Henrike M., Preston, Tom, Van den Mooter, Guy, Verbeke, Kristin A., Vermeulen, Karen   +12 more
core   +1 more source