Results 41 to 50 of about 1,618 (161)

Blurring Borders: Innate Immunity with Adaptive Features

Journal of Immunology Research, Volume 2007, Issue 1, 2007., 2007
Adaptive immunity has often been considered the penultimate of immune capacities. That system is now being deconstructed to encompass less stringent rules that govern its initiation, actual effector activity, and ambivalent results. Expanding the repertoire of innate immunity found in all invertebrates has greatly facilitated the relaxation of ...
K. Kvell, EL. Cooper, P. Engelmann, J. Bovari, P. Nemeth, Yasunobu Yoshikai   +5 more
wiley   +1 more source

The Quest for Antibodies and Other Acquired Immune Receptors: A Historical Perspective

International Journal of Immunogenetics, Volume 52, Issue 3, Page 125-134, June 2025.
ABSTRACT The diversity of antibody molecules has for decades been an unsolved enigma that has attracted wide interest among biologists. Parallel to the accumulation of experimental evidence, progress in antibody research was also driven by the theoretical debate that played a particularly prominent role, at least until the entry of molecular biology ...
Andrea De Lerma Barbaro, Sahar Balkhi, Stefano Giovannardi, Alberto Vianelli, Domenico Ribatti, Lorenzo Mortara   +5 more
wiley   +1 more source

The Effect of PPARα, PPARδ, PPARγ, and PPARpan Agonists on Body Weight, Body Mass, and Serum Lipid Profiles in Diet‐Induced Obese AKR/J Mice

PPAR Research, Volume 2007, Issue 1, 2007., 2007
Activation of peroxisome proliferator‐activated receptor (PPAR) α, δ, and γ subtypes increases expression of genes involved in fatty acid transport and oxidation and alters adiposity in animal models of obesity and type‐2 diabetes. PPARpan agonists which activate all three receptor subtypes have antidiabetic activity in animal models without the weight
W. Wallace Harrington, Christy S. Britt, Joan G. Wilson, Naphtali O. Milliken, Jane G. Binz, David C. Lobe, William R. Oliver, Michael C. Lewis, Diane M. Ignar, Francine M. Gregoire   +9 more
wiley   +1 more source

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Frontiers in Immunology, 2019
Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases.
Obinna C. Ubah, John Steven, Andrew J. Porter, Andrew J. Porter, Caroline J. Barelle   +4 more
doaj   +1 more source

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development

Frontiers in Immunology, 2017
The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics.
Obinna C. Ubah, John Steven, Marina Kovaleva, Laura Ferguson, Charlotte Barelle, Andrew J. R. Porter, Andrew J. R. Porter, Caroline J. Barelle   +7 more
doaj   +1 more source

Low microbial abundance and community diversity in the egg capsule of the oviparous cloudy catshark (Scyliorhinus torazame) during oviposition

Environmental Microbiology Reports, Volume 16, Issue 5, October 2024.
This research reveals that embryos of the oviparous cloudy catshark (Scyliorhinus torazame) acquire pathogen resistance by Stage 30. The intracapsular environment of freshly laid eggs exhibits low microbial abundance and diversity. This clean environment persists until the early opening of the capsule, suggesting its critical role in protecting ...
Wataru Takagi, Ayami Masuda, Koya Shimoyama, Kotaro Tokunaga, Susumu Hyodo, Yuki Sato‐Takabe   +5 more
wiley   +1 more source

Discovering adaptive features of innate immune memory

Immunological Reviews, Volume 323, Issue 1, Page 186-196, May 2024.
Summary Conventionally, it was thought that innate immunity operated through a simple system of nonspecific responses to an insult. However, this perspective now seems overly simplistic. It has become evident that intricate cooperation and networking among various cells, receptors, signaling pathways, and protein complexes are essential for regulating ...
Mina Sadeghi, Maziar Divangahi
wiley   +1 more source

Crystal structure of human serum albumin in complex with megabody reveals unique human and murine cross‐reactive binding site

Protein Science, Volume 33, Issue 2, February 2024.
Abstract The pharmacokinetic properties of small biotherapeutics can be enhanced via conjugation to cross‐reactive albumin‐binding ligands in a process that improves their safety and accelerates testing through multiple pre‐clinical animal models. In this context, the small and stable heavy‐chain‐only nanobody NbAlb1, capable of binding both human and ...
Sofia De Felice, Zhanna Romanyuk, Monica Chinellato, Giulia Zoia, Sara Linciano, Yoichi Kumada, Els Pardon, Jan Steyaert, Alessandro Angelini, Laura Cendron   +9 more
wiley   +1 more source

Nanoparticle‐Based Bioaffinity Assays: From the Research Laboratory to the Market

Advanced Materials, Volume 36, Issue 3, January 18, 2024.
This review critically discusses advances in nanoparticle‐based labels (yellow) combined with biorecognition elements (green) and suitable readout schemes for the design of new bioaffinity assays. The route of nanoparticle‐based assays from the bench to real sample analysis and commercialization follows a rugged path winding between many challenges and
Zdeněk Farka, Julian C. Brandmeier, Matthias J. Mickert, Matěj Pastucha, Karel Lacina, Petr Skládal, Tero Soukka, Hans H. Gorris   +7 more
wiley   +1 more source

Abstracts

Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +2 more sources