Results 41 to 50 of about 1,420 (126)

Remotely Sensed Land Surface Temperature-Based Water Stress Index for Wetland Habitats

Remote Sensing, 2020
Despite covering only 2−6% of land, wetland ecosystems play an important role at the local and global scale. They provide various ecosystem services (carbon dioxide sequestration, pollution removal, water retention, climate regulation, etc.) as ...
Wojciech Ciężkowski, Sylwia Szporak-Wasilewska, Małgorzata Kleniewska, Jacek Jóźwiak, Tomasz Gnatowski, Piotr Dąbrowski, Maciej Góraj, Jan Szatyłowicz, Stefan Ignar, Jarosław Chormański   +9 more
doaj   +1 more source

Anti‐ICOSL New Antigen Receptor Domains Inhibit T Cell Proliferation and Reduce the Development of Inflammation in the Collagen‐Induced Mouse Model of Rheumatoid Arthritis

Journal of Immunology Research, Volume 2018, Issue 1, 2018., 2018
Lymphocyte costimulation plays a central role in immunology, inflammation, and immunotherapy. The inducible T cell costimulator (ICOS) is expressed on T cells following peptide: MHC engagement with CD28 costimulation. The interaction of ICOS with its sole ligand, the inducible T cell costimulatory ligand (ICOSL; also known as B7‐related protein‐1 ...
Ronan O’Dwyer, Marina Kovaleva, Jiquan Zhang, John Steven, Emma Cummins, Deborah Luxenberg, Alfredo Darmanin-Sheehan, Miguel F. Carvalho, Matthew Whitters, Kenneth Saunders, Caroline J. Barelle, Ilaria Roato   +11 more
wiley   +1 more source

Coevolution of Mucosal Immunoglobulins and the Polymeric Immunoglobulin Receptor: Evidence That the Commensal Microbiota Provided the Driving Force

International Scholarly Research Notices, Volume 2014, Issue 1, 2014., 2014
Immunoglobulins (Igs) in mucosal secretions contribute to immune homeostasis by limiting access of microbial and environmental antigens to the body proper, maintaining the integrity of the epithelial barrier and shaping the composition of the commensal microbiota.
Charlotte S. Kaetzel, M. C. Béné, J. L. Stafford   +2 more
wiley   +1 more source

Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A

Applied Research, Volume 4, Issue 3, June 2025.
The development of a nanobody for Nogo‐A, a potent neurite outgrowth inhibitor crucial in multiple sclerosis, is reported using a rational design approach. The nanobody targets the Nogo‐A ectodomain at the S1PR2 receptor‐binding region with submicromolar KD.
Vaidehi Roy Chowdhury, Alexander Röntgen, Matthew Greenig, Yanira Méndez Gómez, Sebastian P. Spiegel, Magdalena Nowinska, Aubin Ramon, Pietro Sormanni, Andrew Chan, Michele Vendruscolo   +9 more
wiley   +1 more source

Blurring Borders: Innate Immunity with Adaptive Features

Journal of Immunology Research, Volume 2007, Issue 1, 2007., 2007
Adaptive immunity has often been considered the penultimate of immune capacities. That system is now being deconstructed to encompass less stringent rules that govern its initiation, actual effector activity, and ambivalent results. Expanding the repertoire of innate immunity found in all invertebrates has greatly facilitated the relaxation of ...
K. Kvell, EL. Cooper, P. Engelmann, J. Bovari, P. Nemeth, Yasunobu Yoshikai   +5 more
wiley   +1 more source

The Quest for Antibodies and Other Acquired Immune Receptors: A Historical Perspective

International Journal of Immunogenetics, Volume 52, Issue 3, Page 125-134, June 2025.
ABSTRACT The diversity of antibody molecules has for decades been an unsolved enigma that has attracted wide interest among biologists. Parallel to the accumulation of experimental evidence, progress in antibody research was also driven by the theoretical debate that played a particularly prominent role, at least until the entry of molecular biology ...
Andrea De Lerma Barbaro, Sahar Balkhi, Stefano Giovannardi, Alberto Vianelli, Domenico Ribatti, Lorenzo Mortara   +5 more
wiley   +1 more source

The Effect of PPARα, PPARδ, PPARγ, and PPARpan Agonists on Body Weight, Body Mass, and Serum Lipid Profiles in Diet‐Induced Obese AKR/J Mice

PPAR Research, Volume 2007, Issue 1, 2007., 2007
Activation of peroxisome proliferator‐activated receptor (PPAR) α, δ, and γ subtypes increases expression of genes involved in fatty acid transport and oxidation and alters adiposity in animal models of obesity and type‐2 diabetes. PPARpan agonists which activate all three receptor subtypes have antidiabetic activity in animal models without the weight
W. Wallace Harrington, Christy S. Britt, Joan G. Wilson, Naphtali O. Milliken, Jane G. Binz, David C. Lobe, William R. Oliver, Michael C. Lewis, Diane M. Ignar, Francine M. Gregoire   +9 more
wiley   +1 more source

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Frontiers in Immunology, 2019
Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases.
Obinna C. Ubah, John Steven, Andrew J. Porter, Andrew J. Porter, Caroline J. Barelle   +4 more
doaj   +1 more source

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralizing Potency and Multifunctionality, Generated for Therapeutic Development

Frontiers in Immunology, 2017
The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics.
Obinna C. Ubah, John Steven, Marina Kovaleva, Laura Ferguson, Charlotte Barelle, Andrew J. R. Porter, Andrew J. R. Porter, Caroline J. Barelle   +7 more
doaj   +1 more source

Low microbial abundance and community diversity in the egg capsule of the oviparous cloudy catshark (Scyliorhinus torazame) during oviposition

Environmental Microbiology Reports, Volume 16, Issue 5, October 2024.
This research reveals that embryos of the oviparous cloudy catshark (Scyliorhinus torazame) acquire pathogen resistance by Stage 30. The intracapsular environment of freshly laid eggs exhibits low microbial abundance and diversity. This clean environment persists until the early opening of the capsule, suggesting its critical role in protecting ...
Wataru Takagi, Ayami Masuda, Koya Shimoyama, Kotaro Tokunaga, Susumu Hyodo, Yuki Sato‐Takabe   +5 more
wiley   +1 more source