Results 51 to 60 of about 4,347 (168)
PPAR Research, Volume 2007, Issue 1, 2007., 2007 Activation of peroxisome proliferator‐activated receptor (PPAR) α, δ, and γ subtypes increases expression of genes involved in fatty acid transport and oxidation and alters adiposity in animal models of obesity and type‐2 diabetes. PPARpan agonists which activate all three receptor subtypes have antidiabetic activity in animal models without the weight
W. Wallace Harrington +9 more
wiley +1 more source
Frontiers in Immunology, 2019 Tumor necrosis factor-alpha (TNF-α), an established pro-inflammatory cytokine plays a central role in the induction and progression of several chronic inflammatory and autoimmune diseases.
Obinna C. Ubah +4 more
doaj +1 more source
From private organizations to democratic infrastructure: Political parties and the state in Estonia [PDF]
, 2006 Estonia, one of the first former Soviet republics to regain independence, had to start the processes of party and state development from scratch, beginning with the development of a legal framework for political parties, establishing a regime of public ...
Sikk, A
core +1 more source
The referee assignment problem [PDF]
, 2019 In collaboration between a UPC spinoff, Barcelogic, and the Dutch Football Federation (KNVB), we define, study, implement and evaluate different approaches for solving the so-called Referee Assignment Problem(RAP).
Vallespi Soro, Farners
core
Development and characterization of a potent free fatty acid receptor 1 (FFA1) fluorescent tracer [PDF]
, 2016 The free fatty acid receptor 1 (FFA1/GPR40) is a potential target for treatment of type 2 diabetes. Although several potent agonists have been described, there remains a strong need for suitable tracers to interrogate ligand binding to this receptor.
Christiansen, Elisabeth +4 more
core +3 more sources
Environmental Microbiology Reports, Volume 16, Issue 5, October 2024.This research reveals that embryos of the oviparous cloudy catshark (Scyliorhinus torazame) acquire pathogen resistance by Stage 30. The intracapsular environment of freshly laid eggs exhibits low microbial abundance and diversity. This clean environment persists until the early opening of the capsule, suggesting its critical role in protecting ...
Wataru Takagi +5 more
wiley +1 more source
Frontiers in Immunology, 2017 The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics.
Obinna C. Ubah +7 more
doaj +1 more source
Discovering adaptive features of innate immune memory
Immunological Reviews, Volume 323, Issue 1, Page 186-196, May 2024.Summary Conventionally, it was thought that innate immunity operated through a simple system of nonspecific responses to an insult. However, this perspective now seems overly simplistic. It has become evident that intricate cooperation and networking among various cells, receptors, signaling pathways, and protein complexes are essential for regulating ...
Mina Sadeghi, Maziar Divangahi
wiley +1 more source
Protein Science, Volume 33, Issue 2, February 2024.Abstract The pharmacokinetic properties of small biotherapeutics can be enhanced via conjugation to cross‐reactive albumin‐binding ligands in a process that improves their safety and accelerates testing through multiple pre‐clinical animal models. In this context, the small and stable heavy‐chain‐only nanobody NbAlb1, capable of binding both human and ...
Sofia De Felice +9 more
wiley +1 more source
Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835 [PDF]
, 2017 A series of spirocyclic compounds inspired by Eli Lilly's phase 1 antidiabetic FFA1 receptor agonist LY2881835 was designed to include polar aromatic periphery groups and explore a possibility of building additional contacts with the target near the ...
Bagnyukova, Daria +8 more
core +1 more source