Results 51 to 60 of about 1,420 (126)

Discovering adaptive features of innate immune memory

Immunological Reviews, Volume 323, Issue 1, Page 186-196, May 2024.
Summary Conventionally, it was thought that innate immunity operated through a simple system of nonspecific responses to an insult. However, this perspective now seems overly simplistic. It has become evident that intricate cooperation and networking among various cells, receptors, signaling pathways, and protein complexes are essential for regulating ...
Mina Sadeghi, Maziar Divangahi
wiley   +1 more source

Crystal structure of human serum albumin in complex with megabody reveals unique human and murine cross‐reactive binding site

Protein Science, Volume 33, Issue 2, February 2024.
Abstract The pharmacokinetic properties of small biotherapeutics can be enhanced via conjugation to cross‐reactive albumin‐binding ligands in a process that improves their safety and accelerates testing through multiple pre‐clinical animal models. In this context, the small and stable heavy‐chain‐only nanobody NbAlb1, capable of binding both human and ...
Sofia De Felice, Zhanna Romanyuk, Monica Chinellato, Giulia Zoia, Sara Linciano, Yoichi Kumada, Els Pardon, Jan Steyaert, Alessandro Angelini, Laura Cendron   +9 more
wiley   +1 more source

Nanoparticle‐Based Bioaffinity Assays: From the Research Laboratory to the Market

Advanced Materials, Volume 36, Issue 3, January 18, 2024.
This review critically discusses advances in nanoparticle‐based labels (yellow) combined with biorecognition elements (green) and suitable readout schemes for the design of new bioaffinity assays. The route of nanoparticle‐based assays from the bench to real sample analysis and commercialization follows a rugged path winding between many challenges and
Zdeněk Farka, Julian C. Brandmeier, Matthias J. Mickert, Matěj Pastucha, Karel Lacina, Petr Skládal, Tero Soukka, Hans H. Gorris   +7 more
wiley   +1 more source

Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody

Virology, 2011
The Hepatitis B virus precore protein is processed in the endoplasmic reticulum (ER) into secreted hepatitis B e antigen (HBeAg), which acts as an immune tolerogen to establish chronic infection. Downregulation of secreted HBeAg should improve clinical outcome, as patients who effectively respond to current treatments (IFN-α) have significantly lower ...
Walsh, Renae, Nuttall, Stewart, Revill, Peter, Colledge, Danni, Cabuang, Liza, Soppe, Sally, Dolezal, Olan, Griffiths, Kate, Bartholomeusz, Angeline, Locarnini, Stephen   +9 more
openaire   +2 more sources

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis [PDF]

Journal of Biological Chemistry, 2013
The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the shark immune system that exist as heavy chain-only homodimers and bind antigens by their single domain variable regions (V-NARs). Following shark immunization and/or in vitro selection, V-NARs can be generated as soluble, stable, and specific high affinity ...
Oleg V, Kovalenko, Andrea, Olland, Nicole, Piché-Nicholas, Adarsh, Godbole, Daniel, King, Kristine, Svenson, Valerie, Calabro, Mischa R, Müller, Caroline J, Barelle, William, Somers, Davinder S, Gill, Lidia, Mosyak, Lioudmila, Tchistiakova   +12 more
openaire   +2 more sources

Abstracts

Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
wiley   +2 more sources

Nanobody-derived nanobiotechnology tool kits for diverse biomedical and biotechnology applications

International Journal of Nanomedicine, 2016
Yongzhong Wang,1 Zhen Fan,2 Lei Shao,3 Xiaowei Kong,1 Xianjuan Hou,1 Dongrui Tian,1 Ying Sun,1 Yazhong Xiao,1 Li Yu4 1School of Life Sciences, Collaborative Innovation Center of Modern Bio-manufacture, Anhui University, Hefei, People’s Republic of
Wang Y, Fan Z, Shao L, Kong X, Hou X, Tian D, Sun Y, Xiao Y, Yu L   +8 more
doaj  

Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers. [PDF]

Cell Rep, 2023
Matz H, Taylor RS, Redmond AK, Hill TM, Ruiz Daniels R, Beltran M, Henderson NC, Macqueen DJ, Dooley H.   +8 more
europepmc   +1 more source

Obrazy polskie w powieści Alaina van Crugtena La dictature des ignares

Polonistyka. Innowacje
Alain van Crugten – urodzony w 1936 roku brukselczyk, profesor Wolnego Uniwersytetu w Brukseli i tłumacz arcydzieł z kanonu literatury europejskiej, znawca prozy i dramatów – przyznaje szczególne miejsce polskiej historii, literaturze i kulturze. Van Crugten ma między innymi na swoim koncie przetłumaczone z języka polskiego na język francuski wszystkie
openaire   +1 more source

Structure-based design of a strain transcending AMA1-RON2L malaria vaccine. [PDF]

Nat Commun, 2023
Patel PN, Dickey TH, Diouf A, Salinas ND, McAleese H, Ouahes T, Long CA, Miura K, Lambert LE, Tolia NH.   +9 more
europepmc   +1 more source