Results 31 to 40 of about 1,420 (126)

Noise reduction and mask removal neural network for X‐ray single‐particle imaging

Journal of Applied Crystallography, Volume 55, Issue 1, Page 122-132, February 2022., 2022
A neural network for coherent X‐ray diffractive imaging experiments is presented that can restore noisy and masked simulated diffraction intensities from biological macromolecules.Free‐electron lasers could enable X‐ray imaging of single biological macromolecules and the study of protein dynamics, paving the way for a powerful new imaging tool in ...
Alfredo Bellisario, Filipe R. N. C. Maia, Tomas Ekeberg   +2 more
wiley   +1 more source

Molecular Origin of the Stability Difference in Four Shark IgNAR Constant Domains [PDF]

Biophysical Journal, 2019
Improving the stability of antibodies for manufacture and shelf life is one of the main focuses of antibody engineering. One stabilization strategy is to perform specific mutations in human antibodies based on highly stable antibodies in other species.
Hong, Zhou, Shengtang, Liu, Xiuhua, Yin, Zengpeng, Li, Zaixing, Yang, Ruhong, Zhou   +5 more
openaire   +2 more sources

The immune system of sturgeons and paddlefish (Acipenseriformes): a review with new data from a chromosome‐scale sturgeon genome

Reviews in Aquaculture, Volume 13, Issue 3, Page 1709-1729, June 2021., 2021
Abstract Sturgeon immunity is relevant for basic evolutionary and applied research, including caviar‐ and meat‐producing aquaculture, protection of wild sturgeons and their re‐introduction through conservation aquaculture. Starting from a comprehensive overview of immune organs, we discuss pathways of innate and adaptive immune systems in a vertebrate ...
Christin Höhne, Dmitry Prokopov, Heiner Kuhl, Kang Du, Christophe Klopp, Sven Wuertz, Vladimir Trifonov, Matthias Stöck   +7 more
wiley   +1 more source

Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments

mAbs, 2021
Phage display technology in combination with next-generation sequencing (NGS) currently is a state-of-the-art method for the enrichment and isolation of monoclonal antibodies from diverse libraries.
Francesco Nannini, Lenart Senicar, Farhaan Parekh, Khai J. Kong, Alexander Kinna, Reyisa Bughda, James Sillibourne, Xihao Hu, Biao Ma, Yuchen Bai, Mathieu Ferrari, Martin A. Pule, Shimobi C. Onuoha   +12 more
doaj   +1 more source

Artificial Neural Networks and Computer Vision’s-Based Phytoindication Systems for Variable Rate Irrigation Improving

IEEE Access, 2022
The article proposes a methodology for optimizing the process of irrigation of crops using a phytoindication system based on computer vision methods. We have proposed an algorithm and developed a system for obtaining a map of irrigation for maize in low ...
Galina Kamyshova, Aleksey Osipov, Sergey Gataullin, Sergey Korchagin, Stefan Ignar, Timur Gataullin, Nadezhda Terekhova, Stanislav Suvorov   +7 more
doaj   +1 more source

Mathematical Models and Methods for Research and Optimization of Protein Extraction Processes from Chickpea and Curd Whey Solutions by Electroflotation Coagulation Method

Mathematics, 2022
The development of mathematical models and efficient technologies for the processing of protein-containing dairy and vegetable raw materials and the production of food and feed concentrates with controlled functional properties is one of the most ...
Igor Timofeev, Ekaterina Pleshakova, Elena Dogadina, Aleksey Osipov, Azret Kochkarov, Stefan Ignar, Stanislav Suvorov, Sergey Gataullin, Sergey Korchagin   +8 more
doaj   +1 more source

Diversity and repertoire of IgW and IgM VH families in the newborn nurse shark

BMC Immunology, 2004
Background Adult cartilaginous fish express three immunoglobulin (Ig) isotypes, IgM, IgNAR and IgW. Newborn nurse sharks, Ginglymostoma cirratum, produce 19S (multimeric) IgM and monomeric/dimeric IgM1gj, a germline-joined, IgM-related VH, and very low ...
Dooley Helen, Lohr Rebecca L, Rumfelt Lynn L, Flajnik Martin F   +3 more
doaj   +1 more source

Mapping the effectiveness of nature‐based solutions for climate change adaptation

Global Change Biology, Volume 26, Issue 11, Page 6134-6155, November 2020., 2020
We present the first global systematic map of the effectiveness of nature‐based solutions (NbS) for addressing the impacts of climate change and hydrometeorological hazards on people. We found that most studies on NbS interventions in natural or semi‐natural ecosystems reported reduced climate impacts and that, overall, more synergies than trade‐offs ...
Alexandre Chausson, Beth Turner, Dan Seddon, Nicole Chabaneix, Cécile A. J. Girardin, Valerie Kapos, Isabel Key, Dilys Roe, Alison Smith, Stephen Woroniecki, Nathalie Seddon   +10 more
wiley   +1 more source

Structure of an IgNAR-AMA1 Complex: Targeting a Conserved Hydrophobic Cleft Broadens Malarial Strain Recognition [PDF]

Structure, 2007
Apical membrane antigen 1 (AMA1) is essential for invasion of erythrocytes and hepatocytes by Plasmodium parasites and is a leading malarial vaccine candidate. Although conventional antibodies to AMA1 can prevent such invasion, extensive polymorphisms within surface-exposed loops may limit the ability of these AMA1-induced antibodies to protect against
Nuttall, Stewart D., Foley, Michael., Anders, Robin Fedric., Murphy, Vincent., Bai, Tao., Gupta, Aditi., Batchelor, Adrian H., Hudson, Peter J., Dolezal, Olan., Coley, Andrew Mark., Streltsov, Victor A., Henderson, Kylie Anne.   +11 more
openaire   +2 more sources

Efficient Construction and Effective Screening of Synthetic Domain Antibody Libraries

Methods and Protocols, 2019
Phage display is a powerful technique for drug discovery in biomedical research in particular for antibody libraries. But, several technical challenges are associated with the selection process.
Arghavan Solemani Zadeh, Alissa Grässer, Heiko Dinter, Maximilian Hermes, Katharina Schindowski   +4 more
doaj   +1 more source