In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development [PDF]
, 2017 Acknowledgments: The authors would like to acknowledge the funding support for this work from Scottish Enterprise [VNAR_001(2012)] and the Biotechnology and Biological Sciences Research Council (BB/K010905/1).Peer reviewedPublisher ...
Andrew J. Porter +11 more
core +2 more sources
Mathematics, 2022 The development of mathematical models and efficient technologies for the processing of protein-containing dairy and vegetable raw materials and the production of food and feed concentrates with controlled functional properties is one of the most ...
Igor Timofeev +8 more
doaj +1 more source
The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice. [PDF]
, 2015 RATIONALE Using the drinking-in-the-dark (DID) model, we compared the effects of a novel mu-opioid receptor antagonist, GSK1521498, with naltrexone, a licensed treatment of alcohol dependence, on ethanol consumption in mice.
C Giuliano +33 more
core +1 more source
Mapping the effectiveness of nature‐based solutions for climate change adaptation
Global Change Biology, Volume 26, Issue 11, Page 6134-6155, November 2020., 2020 We present the first global systematic map of the effectiveness of nature‐based solutions (NbS) for addressing the impacts of climate change and hydrometeorological hazards on people. We found that most studies on NbS interventions in natural or semi‐natural ecosystems reported reduced climate impacts and that, overall, more synergies than trade‐offs ...
Alexandre Chausson +10 more
wiley +1 more source
The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs [PDF]
, 2013 G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential.
Hudson, Brian D. +2 more
core +1 more source
The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. [PDF]
, 2015 Distinct environmental and conditioned stimuli influencing ethanol-associated appetitive and consummatory behaviors may jointly contribute to alcohol addiction.
Belin, David +7 more
core +5 more sources
Can aggregate quarry silt lagoons provide resources for wading birds? [PDF]
, 2017 Wading birds have declined across Europe as the intensification of lowland agriculture has resulted in the loss and degradation of wetland areas. Lowland aggregate extraction sites that incorporate areas of fine, waste sediments deposited in silt lagoons
Day, George +3 more
core +2 more sources
Treatment of type 2 diabetes by free fatty acid receptor agonists [PDF]
, 2014 Dietary free fatty acids (FFAs), such as ω-3 fatty acids, regulate metabolic and anti-inflammatory processes, with many of these effects attributed to FFAs interacting with a family of G protein-coupled receptors.
Hudson, Brian D. +3 more
core +2 more sources
Analysis of the binding loops configuration and surface adaptation of different crystallized single‐domain antibodies in response to various antigens [PDF]
, 2017 Monoclonal antibodies have revolutionized the biomedical field through their ubiquitous utilization in different diagnostics and therapeutic applications.
Al Qaraghuli +93 more
core +1 more source
Structure of a shark IgNAR antibody variable domain and modeling of an early‐developmental isotype [PDF]
Protein Science, 2005 AbstractThe new antigen receptor (IgNAR) antibodies from sharks are disulphide bonded dimers of two protein chains, each containing one variable and five constant domains. Three types of IgNAR variable domains have been discovered, with Type 3 appearing early in shark development and being overtaken by the antigen‐driven affinity‐matured Type 1 and 2 ...
Victor A, Streltsov +2 more
openaire +2 more sources