Structural insights and biomedical potential of IgNAR scaffolds from sharks [PDF]
mAbs, 2014 Peer reviewedPublisher ...
Barelle, Caroline +5 more
core +5 more sources
Geoscience Data Journal, 2023 Long‐term simulated water balance and streamflow data for the territory of Poland with high spatio‐temporal resolution were reconstructed for the period 1951–2020 with a daily time step, using the Soil and Water Assessment Tool (SWAT) hydrological model.
Paweł Marcinkowski +8 more
doaj +2 more sources
Unique antibodies across the animal kingdom (birds, camelids, and sharks): therapeutic potential against human respiratory viral infections [PDF]
Frontiers in ImmunologyAntibodies represent indispensable tools in the armamentarium against infectious diseases, with widespread application in prophylactic, therapeutic, and diagnostic settings.
Ammar A. Basabrain +3 more
doaj +2 more sources
Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (Chiloscyllium plagiosum) [PDF]
Marine Drugs, 2022 Tumor necrosis factor α (TNFα), an important clinical testing factor and drug target, can trigger serious autoimmune diseases and inflammation. Thus, the TNFα antibodies have great potential application in diagnostics and therapy fields.
Linfei Zhao +5 more
doaj +2 more sources
VNAR: shark single-domain antibodies for the new era of medical biotechnology [PDF]
Frontiers in ImmunologyShark-derived single-domain antibodies, known as VNARs, represent unique and advanced tools in medical biotechnology. Recognized for their small size, simple structure, and exceptional stability, VNARs can access cryptic epitopes that are inaccessible to
Richard A. Olivares-Olivares +19 more
doaj +2 more sources
A novel shark single-domain antibody targeting OGT as a tool for detection and intracellular localization [PDF]
Frontiers in Immunology, 2023 IntroductionO-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues of intracellular proteins in eukaryotic cells, which is generated by the sole O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA).
Xiaozhi Xi +21 more
doaj +2 more sources
Novel Approach for Obtaining Variable Domain of New Antigen Receptor with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica) [PDF]
Marine Drugs, 2023 Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has attracted attention owing to its favorable physicochemical properties.
Tomofumi Nakada-Masuta +2 more
doaj +2 more sources
Characteristics and Genomic Localization of Nurse Shark (Ginglymostoma cirratum) IgNAR. [PDF]
Int J Mol SciThe variable domain of IgNAR shows great potential in biological medicine and therapy. IgNAR has been discovered in sharks and rays, with the nurse shark (Ginglymostoma cirratum) IgNARs being the most extensively studied among sharks. Despite being identified in nurse sharks over 30 years ago, the characteristics and genomic localization of IgNAR ...
Tang W +12 more
europepmc +3 more sources
Single domain antibody: Development and application in biotechnology and biopharma. [PDF]
Immunol RevSummary Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb).
Yu T +4 more
europepmc +2 more sources
Frontiers in Molecular Biosciences, 2021 Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system.
Monica L. Fernández-Quintero +3 more
doaj +1 more source