Identification and characterization of IgNAR and VNAR repertoire from the ocellate spot skate (Okamejei kenojei) [PDF]
Frontiers in Marine Science, 2023 Elasmobranchs are crucial for comparative studies of evolution, as they belong to the most ancient vertebrate lineages that survived numerous extinction events and persist until today.
Jianqing Wen +14 more
doaj +3 more sources
Characteristics and Genomic Localization of Nurse Shark (Ginglymostoma cirratum) IgNAR. [PDF]
Int J Mol SciThe variable domain of IgNAR shows great potential in biological medicine and therapy. IgNAR has been discovered in sharks and rays, with the nurse shark (Ginglymostoma cirratum) IgNARs being the most extensively studied among sharks. Despite being identified in nurse sharks over 30 years ago, the characteristics and genomic localization of IgNAR ...
Tang W +12 more
europepmc +4 more sources
The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Sharks are among the evolutionary oldest living organisms with an immune system that possesses a number of elements similar to ours, including antibodies. In this article, we present structural insights into one of the most ancient antibodies, shedding light on the molecular evolution of the immune system and the ...
Feige, Matthias J. +13 more
openaire +4 more sources
Geoscience Data Journal, 2023 Long‐term simulated water balance and streamflow data for the territory of Poland with high spatio‐temporal resolution were reconstructed for the period 1951–2020 with a daily time step, using the Soil and Water Assessment Tool (SWAT) hydrological model.
Paweł Marcinkowski +8 more
doaj +2 more sources
Structure of an IgNAR-AMA1 Complex: Targeting a Conserved Hydrophobic Cleft Broadens Malarial Strain Recognition [PDF]
Structure, 2007 Apical membrane antigen 1 (AMA1) is essential for invasion of erythrocytes and hepatocytes by Plasmodium parasites and is a leading malarial vaccine candidate. Although conventional antibodies to AMA1 can prevent such invasion, extensive polymorphisms within surface-exposed loops may limit the ability of these AMA1-induced antibodies to protect against
Nuttall, Stewart D. +11 more
openaire +4 more sources
VNAR: shark single-domain antibodies for the new era of medical biotechnology [PDF]
Frontiers in ImmunologyShark-derived single-domain antibodies, known as VNARs, represent unique and advanced tools in medical biotechnology. Recognized for their small size, simple structure, and exceptional stability, VNARs can access cryptic epitopes that are inaccessible to
Richard A. Olivares-Olivares +19 more
doaj +2 more sources
Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody [PDF]
Virology, 2011 The Hepatitis B virus precore protein is processed in the endoplasmic reticulum (ER) into secreted hepatitis B e antigen (HBeAg), which acts as an immune tolerogen to establish chronic infection. Downregulation of secreted HBeAg should improve clinical outcome, as patients who effectively respond to current treatments (IFN-α) have significantly lower ...
Walsh, Renae +9 more
openaire +3 more sources
A novel shark single-domain antibody targeting OGT as a tool for detection and intracellular localization [PDF]
Frontiers in Immunology, 2023 IntroductionO-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues of intracellular proteins in eukaryotic cells, which is generated by the sole O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA).
Xiaozhi Xi +21 more
doaj +2 more sources
Novel Approach for Obtaining Variable Domain of New Antigen Receptor with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica) [PDF]
Marine Drugs, 2023 Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has attracted attention owing to its favorable physicochemical properties.
Tomofumi Nakada-Masuta +2 more
doaj +2 more sources
Single domain antibody: Development and application in biotechnology and biopharma. [PDF]
Immunol RevSummary Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb).
Yu T +4 more
europepmc +2 more sources