Results 21 to 30 of about 1,420 (126)

Unique antibodies across the animal kingdom (birds, camelids, and sharks): therapeutic potential against human respiratory viral infections [PDF]

Frontiers in Immunology
Antibodies represent indispensable tools in the armamentarium against infectious diseases, with widespread application in prophylactic, therapeutic, and diagnostic settings.
Ammar A. Basabrain, Ammar A. Basabrain, Thamir A. Alandijany, Thamir A. Alandijany   +3 more
doaj   +2 more sources

Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (Chiloscyllium plagiosum) [PDF]

Marine Drugs, 2022
Tumor necrosis factor α (TNFα), an important clinical testing factor and drug target, can trigger serious autoimmune diseases and inflammation. Thus, the TNFα antibodies have great potential application in diagnostics and therapy fields.
Linfei Zhao, Mingliang Chen, Xiaona Wang, Shoukai Kang, Weiwei Xue, Zengpeng Li   +5 more
doaj   +2 more sources

VNAR: shark single-domain antibodies for the new era of medical biotechnology [PDF]

Frontiers in Immunology
Shark-derived single-domain antibodies, known as VNARs, represent unique and advanced tools in medical biotechnology. Recognized for their small size, simple structure, and exceptional stability, VNARs can access cryptic epitopes that are inaccessible to
Richard A. Olivares-Olivares, Richard A. Olivares-Olivares, Angélica R. Bravo, Angélica R. Bravo, Carlos Garrido-Soto, Carlos Garrido-Soto, Jonatan J. Carvajal, Jonatan J. Carvajal, Augusto Manubens, Mariella Rivas, Mariella Rivas, Carlos Bustamente, Angello Retamal-Díaz, Angello Retamal-Díaz, Angello Retamal-Díaz, Alexis M. Kalergis, Alexis M. Kalergis, Margarita K. Lay, Margarita K. Lay, Margarita K. Lay   +19 more
doaj   +2 more sources

A novel shark single-domain antibody targeting OGT as a tool for detection and intracellular localization [PDF]

Frontiers in Immunology, 2023
IntroductionO-GlcNAcylation is a type of reversible post-translational modification on Ser/Thr residues of intracellular proteins in eukaryotic cells, which is generated by the sole O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA).
Xiaozhi Xi, Xiaozhi Xi, Xiaozhi Xi, Guokai Xiao, Guokai Xiao, Guokai Xiao, Guiqi An, Lin Liu, Xiaochun Liu, Peiyu Hao, Peiyu Hao, Peiyu Hao, Jennifer Yiyang Wang, Dandan Song, Dandan Song, Dandan Song, Wengong Yu, Wengong Yu, Wengong Yu, Yuchao Gu, Yuchao Gu, Yuchao Gu   +21 more
doaj   +2 more sources

Novel Approach for Obtaining Variable Domain of New Antigen Receptor with Different Physicochemical Properties from Japanese Topeshark (Hemitriakis japanica) [PDF]

Marine Drugs, 2023
Diverse candidate antibodies are needed to successfully identify therapeutic and diagnostic applications. The variable domain of IgNAR (VNAR), a shark single-domain antibody, has attracted attention owing to its favorable physicochemical properties.
Tomofumi Nakada-Masuta, Hiroyuki Takeda, Kazuhisa Uchida   +2 more
doaj   +2 more sources

Single domain antibody: Development and application in biotechnology and biopharma. [PDF]

Immunol Rev
Summary Heavy‐chain antibodies (HCAbs) are a unique type of antibodies devoid of light chains, and comprised of two heavy chains‐only that recognize their cognate antigen by virtue of a single variable domain also referred to as VHH, single domain antibody (sdAb), or nanobody (Nb).
Yu T, Zheng F, He W, Muyldermans S, Wen Y.   +4 more
europepmc   +2 more sources

Shark Antibody Variable Domains Rigidify Upon Affinity Maturation—Understanding the Potential of Shark Immunoglobulins as Therapeutics

Frontiers in Molecular Biosciences, 2021
Sharks and other cartilaginous fish are the phylogenetically oldest living organisms that have antibodies as part of their adaptive immune system.
Monica L. Fernández-Quintero, Clarissa A. Seidler, Patrick K. Quoika, Klaus R. Liedl   +3 more
doaj   +1 more source

Spatial mapping of the leaf area index using remote sensing and ground measurements – the Biebrza National Park case study

Przegląd Naukowy Inżynieria i Kształtowanie Środowiska, 2023
The purpose of the described research was an attempt to estimate the leaf area index (LAI) parameter describing the structure of the vegetation based on the Landsat 5TM satellite imagery and field measurements made with the use of an optical plant ...
Stefan Ignar, Sylwia Szporak-Wasilewska, Małgorzata Gregorczyk   +2 more
doaj   +1 more source

Recent advances of nanobody applications in diagnosis and detection

MedComm – Biomaterials and Applications, Volume 2, Issue 3, September 2023., 2023
Nanobodies (Nbs) are the variable domain of heavy‐chain antibodies derived from the blood of camelids or sharks. In this review, we summarize recent advances in the discovery and production of novel nanobodies, and their use in detection and diagnosis platforms.
Qianling Su, Wei Shi, Xianing Huang, Shihua Yin, Xiaomei Yang, Xiaoling Lu   +5 more
wiley   +1 more source

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Sharks are among the evolutionary oldest living organisms with an immune system that possesses a number of elements similar to ours, including antibodies. In this article, we present structural insights into one of the most ancient antibodies, shedding light on the molecular evolution of the immune system and the structural ...
Matthias J, Feige, Melissa A, Gräwert, Moritz, Marcinowski, Janosch, Hennig, Julia, Behnke, David, Ausländer, Eva M, Herold, Jirka, Peschek, Caitlin D, Castro, Martin, Flajnik, Linda M, Hendershot, Michael, Sattler, Michael, Groll, Johannes, Buchner   +13 more
openaire   +2 more sources