Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review [PDF]
Journal of Inflammation ResearchYuan Xu, Jing-Yan Wang, Yang Zou, Xue-Wei Ma, Tian Meng College of Health Industry, Sichuan Tourism University, Chengdu, Sichuan, 610100, People’s Republic of ChinaCorrespondence: Yuan Xu, Email 230973159@qq.comAbstract: Inflammatory cytokines ...
Xu Y, Wang JY, Zou Y, Ma XW, Meng T
doaj +4 more sources
Dichotomous roles of IL-36 and IL-38 in cardiovascular disease [PDF]
Frontiers in ImmunologyMembers of the interleukin-1 (IL-1) superfamily play crucial roles in orchestrating inflammation and immune responses. Among them, IL-36 and IL-38 have emerged as cytokines with contrasting roles in cardiovascular disease (CVD).
Haifeng Zhang, Wenhui Huang, Shisan Bao
doaj +4 more sources
Influence of serum IL-36 subfamily cytokines on clinical manifestations of asthma [PDF]
Journal of Allergy and Clinical Immunology: GlobalBackground: The IL-36 subfamily, a member of the IL-1 superfamily, is thought to promote type 2 (T2) and non-T2 inflammation and involved in autoimmune and airway disease progression. However, its role in asthma remains unclear.
Yuki Hoshino, MD +11 more
doaj +3 more sources
IL-17A-driven psoriasis is critically dependent on IL-36 signaling [PDF]
Frontiers in Immunology, 2023 Plaque psoriasis is an autoinflammatory and autoimmune skin disease, affecting 1-3% of the population worldwide. Previously, high levels of IL-36 family cytokines were found in psoriatic skin lesions, thereby contributing to keratinocyte ...
Berenice Fischer +13 more
doaj +2 more sources
Function and Regulation of IL-36 Signaling in Inflammatory Diseases and Cancer Development [PDF]
Frontiers in Cell and Developmental Biology, 2019 The IL-36 subfamily of cytokines belongs to the IL-1 superfamily and consists of three pro-inflammatory agonists IL-36α, IL-36β, IL-36γ, and an IL-36 receptor (IL-36R) antagonist, IL-36Ra.
Dawn Queen +2 more
doaj +2 more sources
The Role of IL-36 in Infectious Diseases: Potential Target for COVID-19? [PDF]
Frontiers in Immunology, 2021 IL-36 is a member of the interleukin 1 cytokine family, which is currently experiencing a renaissance due to the growing understanding of its context-dependent roles and advances in our understanding of the inflammatory response.
Xiaofang Wang +4 more
doaj +2 more sources
The role of IL-36 and 37 in hepatocellular carcinoma [PDF]
Frontiers in ImmunologyHepatocellular carcinoma (HCC) has garnered considerable attention due to its morbidity and mortality. Although the precise mechanisms underlying HCC tumorigenesis remain to be elucidated, evidence suggests that host immunity plays a pivotal role in its ...
Juan Cao +7 more
doaj +2 more sources
IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic [PDF]
Frontiers in Immunology, 2022 Interleukin (IL)-36 cytokines are members of the IL-1 superfamily, which consists of three agonists (IL-36α, IL-36β and IL-36γ) and an IL-36 receptor antagonist (IL-36Ra). IL-36 cytokines are crucial for immune and inflammatory responses. Abnormal levels
Hongna Dong +4 more
doaj +2 more sources
IL-36 participated in airway remodeling in chronic asthma model by inducing epithelial–mesenchymal transition process [PDF]
European Journal of Medical ResearchPurpose Epithelial–mesenchymal transition (EMT) is a major pathological characteristic of airway remodelling in severe asthma. Interleukin (IL)-36 belongs to the IL-1 family and is associated with allergic disease, but the role of IL-36 in airway ...
Min Zhang +7 more
doaj +2 more sources
IL-1α and IL-36 Family Cytokines Can Undergo Processing and Activation by Diverse Allergen-Associated Proteases [PDF]
Frontiers in Immunology, 2022 Inflammation driven by environmental allergens is an important source of morbidity in diseases such as asthma and eczema. How common allergens promote inflammation is still poorly understood, but previous studies have implicated the protease activity ...
Valentina Frezza +4 more
doaj +2 more sources