Results 21 to 30 of about 1,058,742 (271)

Genome wide analysis of gene expression changes in skin from patients with type 2 diabetes [PDF]

, 2020
Non-healing chronic ulcers are a serious complication of diabetes and are a major healthcare problem. While a host of treatments have been explored to heal or prevent these ulcers from forming, these treatments have not been found to be consistently ...
A Avogaro, A Gaultier, A Le Guelte, A Magli, AA Anderson, AE Rodríguez-Fraticelli, AJ Monteforte, B Shu, BG Seligman, C Ling, C Margadant, C Ozbayer, C Shi, C Tian, C Ung, C Vanderplanck, C Wu, D Bosnakovski, D Bosnakovski, D Karthik, D Lazzaro, DJ Mangelsdorf, DM D'Souza, DS Frankel, E Ansseau, E Ansseau, E Nilsson, EA Coon, EA Malt, EM Small, F Gragnano, F Guan, G Theocharidis, G. Said, GH Wong, GJ Berry, GJ Berry, GL Bellot, GV Gnoni, H Andersen, H Brem, HA Ramirez, I Bettahi, I Bettahi, I Chakroun, I Gottfried, IN Vial, J Thimmarayappa, J Xu, J Yan, JB Rice, JC Corton, JG Van Vranken, JS Hansen, K Blackburn, KM Popov, L Nasarre, L Tan, LA Berchtold, LE Reynolds, M Gupta, M Wight, MA Faghihi, MK Montgomery, MR Tanner, MR Tanner, N Schonrock, N Takagi, NY Yoshihito Nogusa, P Hebbar, P Rajendran, PJ Batista, PM Mannucci, RB Tajhya, RC Pink, RN Weijers, RS Kaplan, RS Kiss, S Baldari, S Barrientos, S Das, S Das, S Lambert, S Rovira-Llopis, S Roy, S Sethumadhavan, SM Weis, SS Kulkarni, SV Suryavanshi, SY Park, T Fujiwara, T Khalfaoui, T Thiruvoipati, T Wang, T-H Wang, TT Hien, V Iacobazzi, V Miragliotta, VV Sinyov, W Meng, WI Sivitz, WM Longmate, WM Longmate, X Shi, X Wang, X Xie, X Yuan, X Zhao, X Zhao, Y Cai, Y Carrier, Y Chen, Y Gu, Y Konishi, Y Liu, Y Wang, Y-T Chen, Y-Y Hsieh, Z Jiang, Z-X Meng, ZKK Lawi   +120 more
core   +1 more source

Structural Basis of IL-1 Family Cytokine Signaling

Frontiers in Immunology, 2019
Interleukin-1 (IL-1) family cytokines are key signaling molecules in both the innate and adaptive immune systems, mediating inflammation in response to a wide range of stimuli.
James K. Fields, James K. Fields, James K. Fields, Sebastian Günther, Eric J. Sundberg, Eric J. Sundberg, Eric J. Sundberg   +6 more
doaj   +1 more source

IL-36γ has proinflammatory effects on human endothelial cells [PDF]

, 2016
Interleukin-36 cytokines are predominantly expressed by epithelial cells. Significant upregulation of epidermal IL-36 is now a recognised characteristic of psoriatic skin inflammation.
Alase, Adewonuola, Bridgewood, Charlie, Graham, Anne, Lagos, Dimitris, Stacey, Martin, Wittmann, Miriam   +5 more
core   +2 more sources

IL-36α Exerts Pro-Inflammatory Effects in the Lungs of Mice [PDF]

, 2012
Interleukin (IL-) 36 cytokines (previously designated as novel IL-1 family member cytokines; IL-1F5– IL-1F10) constitute a novel cluster of cytokines structurally and functionally similar to members of the IL-1 cytokine cluster.
Ewart, Susan L., Iwakura, Yoichiro, LeVine, Ann Marie, Medoff, Benjamin D., Ramadas, Ravisankar A.   +4 more
core   +3 more sources

The Proinflammatory Cytokine IL-36γ Is a Global Discriminator of Harmless Microbes and Invasive Pathogens within Epithelial Tissues

Cell Reports, 2020
Summary: Epithelial tissues represent vital interfaces between organisms and their environment. As they are constantly exposed to harmful pathogens, innocuous commensals, and environmental microbes, it is essential they sense and elicit appropriate ...
Thomas Macleod, Joseph S. Ainscough, Christina Hesse, Sebastian Konzok, Armin Braun, Anna-Lena Buhl, Joerg Wenzel, Paul Bowyer, Yutaka Terao, Sarah Herrick, Miriam Wittmann, Martin Stacey   +11 more
doaj   +1 more source

Interleukin(IL)-36α and IL-36γ Induce Proinflammatory Mediators from Human Colonic Subepithelial Myofibroblasts [PDF]

, 2015
Background: Interleukin (IL)-36 cytokines are recently reported member of the IL-1 cytokine family. However, there is little information regarding the association between IL-36 cytokines and gut inflammation.
Akira Andoh, Atsushi Nishida, Hirotsugu Imaeda, Kenichiro Takahashi, Kentaro Hidaka, Mitsushige Sugimoto, Osamu Inatomi, Shigeki Bamba, Toshihiro Kanda   +8 more
core   +3 more sources

The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier

Frontiers in Immunology, 2021
The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked.
Tom Macleod, Tom Macleod, Anna Berekmeri, Charlie Bridgewood, Martin Stacey, Dennis McGonagle, Dennis McGonagle, Miriam Wittmann, Miriam Wittmann   +8 more
doaj   +1 more source

Elevated Expression and Pro-Inflammatory Activity of IL-36 in Patients with Systemic Lupus Erythematosus [PDF]

, 2015
published_or_final_versio
Cai, Z, Chu, M, Dong, J, Jiao, D, Kam, NW, Lam, C, Tam, L, Wong, C   +7 more
core   +2 more sources

Limited Contribution of IL-36 versus IL-1 and TNF Pathways in Host Response to Mycobacterial Infection [PDF]

, 2015
IL-36 cytokines are members of the IL-1 family of cytokines that stimulate dendritic cells and T cells leading to enhanced T helper 1 responses in vitro and in vivo ; however, their role in host defense has not been fully addressed thus far.
Bourigault, Marie-Laure, Gabay, Cem, Garcia, Irene, Olleros, Maria L., Palmer, Gaby, Quesniaux, Valérie F. J., Ryffel, Bernhard, Segueni, Noria, Vesin, Dominique, Vigne, Solenne   +9 more
core   +2 more sources

The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab

Frontiers in Immunology, 2023
Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder characterized by recurrent flares associated with skin erythema, desquamation, and widespread superficial sterile pustules, which may be severe (“lakes of pus”). Systemic
Jason E. Hawkes, Sudha Visvanathan, James G. Krueger   +2 more
doaj   +1 more source