Results 11 to 20 of about 1,058,742 (271)

Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis

eLife, 2020
Despite the introduction of biologics, topical dithranol (anthralin) has remained one of the most effective anti-psoriatic agents. Serial biopsies from human psoriatic lesions and both the c-Jun/JunB and imiquimod psoriasis mouse model allowed us to ...
Theresa Benezeder, Clemens Painsi, VijayKumar Patra, Saptaswa Dey, Martin Holcmann, Bernhard Lange-Asschenfeldt, Maria Sibilia, Peter Wolf   +7 more
doaj   +2 more sources

IL-36-related genes predict prognosis of gastric cancer [PDF]

Frontiers in Oncology
IntroductionGastric cancer (GC) is one of the most frequently encountered malignant tumors in the clinic. Because effective early screening techniques are lacking, most patients have advanced disease at first diagnosis.
Ying Zhang, Yanbo Liu, Xin Guan, Meng Qu, Dianxiu Wu, Ning Liu, Zhengkun Lin, Yuqi Liu, Han Wang, Lijuan Yang   +9 more
doaj   +2 more sources

IL-37 and IL-36 Cytokine Profiles in Chronic Hepatitis Delta During Bulevirtide Therapy [PDF]

Pathogens
Chronic hepatitis delta is the most severe form of viral hepatitis and is associated with rapid progression to cirrhosis and hepatocellular carcinoma. Although bulevirtide (BLV) effectively inhibits hepatitis D virus (HDV) entry, immunological biomarkers
Verdiana Zulian, Martina De Sanctis, Silvia Pauciullo, Roberta Sciamanna, Eleonora Cimini, Paola Del Porto, Anna Rosa Garbuglia   +6 more
doaj   +2 more sources

IL-36 receptor agonist and antagonist imbalance drives neutrophilic inflammation in COPD. [PDF]

JCI Insight, 2022
Baker JR, Fenwick PS, Koss CK, Owles HB, Elkin SL, Fine J, Thomas M, El Kasmi KC, Barnes PJ, Donnelly LE.   +9 more
europepmc   +3 more sources

Cross-spectrum efficacy of spesolimab in IL-36-mediated dermatoses: a ′case study

Journal of Dermatological Treatment
Background The nosological distinction between acute generalized exanthematous pustulosis (AGEP) and generalized pustular psoriasis (GPP) has become increasingly unclear due to shared IL-36 pathway dysregulation.
RuoYan Tong, ChaoChao Chen, Ling Huang, ChangWen Ni   +3 more
doaj   +2 more sources

IL-36 cytokines in inflammatory and malignant diseases: not the new kid on the block anymore. [PDF]

Cell Mol Life Sci, 2021
Byrne J, Baker K, Houston A, Brint E.
europepmc   +3 more sources

Up-regulated IL-36 expression promotes a pro-tumorigenic phenotype in pancreatic ductal adenocarcinoma. [PDF]

Genes Dis
An J, Liao Q, Yu Z, Du Z, Du J, Xiao Q, Jiang T, Huang C, Xie K.   +8 more
europepmc   +2 more sources

Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis. [PDF]

JCI Insight
Seki T, Kim JD, Yahara Y, Uchida H, Yaku K, Karim M, Makino T, Shimizu T, Nakagawa T.   +8 more
europepmc   +3 more sources

IkBζ is a Key Regulator of Tumour Necrosis Factor-a and Interleukin-17A-mediated Induction of Interleukin-36g in Human Keratinocytes

Acta Dermato-Venereologica, 2021
The interleukin (IL)-36 cytokine family plays an essential role in inflammatory processes in the skin and is implicated in the pathogenesis of psoriasis. This study explored the role of IL-36 in psoriasis and investigated the molecular mechanism involved
Sofie Kaas Ovesen, Klaus Schulze-Osthoff, Lars Iversen, Claus Johansen   +3 more
doaj   +1 more source

Effect of YangxueJiedu Decoction on the expression levels of IL-36 in psoriasis-like lesions in mice

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To explore the effect of YangxueJiedu decoction on IL-36 expression in a mouse model of imiquimod-induced psoriasis-like lesions. Methods: Eighteen mice were randomly divided into the control, model and experimental groups, with 6 mice per ...
Qi ZHANG, Lei ZHU, Yuqi HUANG, Yongfeng CHEN   +3 more
doaj   +1 more source