Results 91 to 100 of about 1,058,742 (271)

Ohio Livestock Waste Management Guide [PDF]

, 1980
PDF pages ...
Goettemoeller, Robert, Lines, Allan E., Logan, Terry J., Lyon, William F., Moran, Kyle L., White, Richard K.   +5 more
core  

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]

, 1994
Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan, Aguilar-Bryan, Ashcroft, Bayley, De Weille, Ehle, Galizzi, Geisen, Geisen, Glossmann, Glossmann, Hogg, Hollemans, Kramer, Kramer, Kramer, Kramer, Martyr, Müller, Nelson, Nelson, Niki, Ozanne, Panten, Pomerantz, Repke, Schmid-Antomarchi, Schwanstecher, Skeer, Wessel   +29 more
core   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines

Cell Reports, 2016
Recent evidence has strongly implicated the IL-1 family cytokines IL-36α, IL-36β, and IL-36γ as key initiators of skin inflammation. Similar to the other members of the IL-1 family, IL-36 cytokines are expressed as inactive precursors and require ...
Conor M. Henry, Graeme P. Sullivan, Danielle M. Clancy, Inna S. Afonina, Dagmar Kulms, Seamus J. Martin   +5 more
doaj   +1 more source

Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ [PDF]

, 2017
The pro-inflammatory cytokine IL-36γ is highly expressed in epithelial cells and is a pivotal mediator of epithelial inflammation. In particular, IL-36γ is strongly associated with the inflammatory skin disease psoriasis. As with other IL-1 cytokines, IL-
Ade Alase, Boutet, Brix, Buchan, Dennis McGonagle, Dinarello, Enk, Henry, Jens M. Baron, Joseph S. Ainscough, Macleod, Mahil, Martin, Martin Stacey, Miriam Wittmann, Ozdemir, Papini, Rosella Brakefield, Rubartelli, Schönefuss, Tom Macleod   +20 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Psoriasis pustulosa generalizada: de la inmunopatogénesis a la clínica

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 2017
El síndrome DITRA (Interleukin-36-Receptor Antagonist Deficiency) es una enfermedad autoinflamatoria debida a mutaciones del gen IL36RN que producen deficiencia del antagonista del receptor de la IL-36, lo que induce una cascada inflamatoria que lleva a
Andrea Castaño, Margarita María Velásquez   +1 more
doaj   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

T2 A novel drug target: IL-36 signalling drives inflammation and poor bacterial clearance in COPD [PDF]

, 2023
HLB Owles, JR Baker, P.S. Fenwick, SL Elkin, KC Kasmi, Peter J. Barnes, LE Donnelly   +6 more
openalex   +1 more source