Results 1 to 10 of about 2,339,252 (343)

IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation

Respiratory Research, 2018
Background Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces neutrophilic inflammation. It may also increase Th2-type cytokine expression.
Irma Mahmutovic Persson, Mandy Menzel, Sangeetha Ramu, Samuel Cerps, Hamid Akbarshahi, Lena Uller   +5 more
doaj   +2 more sources

Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interaction.

PLoS ONE, 2023
Interleukin-1β (IL-1β) is one of the most potent pro-inflammatory cytokines implicated in a wide range of autoinflammatory, autoimmune, infectious, and degenerative diseases.
Hae-Ri Lee, Young-Jin Jeong, Joong-Woon Lee, JooYeon Jhun, Hyun Sik Na, Keun-Hyung Cho, Seok Jung Kim, Mi-La Cho, Tae-Hwe Heo   +8 more
doaj   +2 more sources

Relationship between IL-6, IL-1β, and vitamin D on frailty status in elderly women

Bali Medical Journal, 2021
Background: The aging process is associated with an increase in proinflammatory markers' serum levels, indicating that a chronic inflammatory process is correlated with an increase in disability, mortality, and frailty. Pro-inflammatory cytokines that increase with the incidence of frailty syndrome are IL-6, IL-1β and TNF-α.
Dwi Ngestiningsih, Jessa Kris Dayanti, Lusiana Batubara   +2 more
openaire   +1 more source

Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts.

PLoS ONE, 2021
In autoimmune diseases, fibroblasts produce and secrete various cytokines and act as sentinel immune cells during inflammatory states. However, the contribution of sentinel immune cells (i.e.
Atsuto Naruke, Rei Nakano, Junichi Nunomura, Yoko Suwabe, Masumi Nakano, Shinichi Namba, Taku Kitanaka, Nanako Kitanaka, Hiroshi Sugiya, Tomohiro Nakayama   +9 more
doaj   +2 more sources

IL-1β and the Intestinal Epithelial Tight Junction Barrier

Frontiers in Immunology, 2021
The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation.
L. Kaminsky, Rana Al-Sadi, T. Ma
semanticscholar   +1 more source

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL‐1β drives amplified responses in primed astrocytes and neuronal network dysfunction

Alzheimer's & Dementia, 2021
Neuroinflammation contributes to Alzheimer's disease (AD) progression. Secondary inflammatory insults trigger delirium and can accelerate cognitive decline. Individual cellular contributors to this vulnerability require elucidation.
A. Lopez-Rodriguez, E. Hennessy, C. Murray, Arshed Nazmi, Hugh J. Delaney, Dáire Healy, S. Fagan, Michael Rooney, Erika Stewart, Anouchka Lewis, N. Barra, Philip L. Scarry, Louise Riggs-Miller, D. Boche, M. Cunningham, C. Cunningham   +15 more
semanticscholar   +1 more source

Inhibition of the NLRP3/IL‐1β axis protects against sepsis‐induced cardiomyopathy

Journal of Cachexia, Sarcopenia and Muscle, 2021
Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome, compromises cardiac function.
Katharina Busch, Melanie Kny, Nora Huang, T. Klassert, Magdalena Stock, Alexander Hahn, Sebastian Graeger, M. Todiras, S. Schmidt, B. Chamling, M. Willenbrock, Stefan Gross, Doreen Biedenweg, A. Heuser, C. Scheidereit, C. Butter, S. Felix, O. Otto, F. Luft, H. Slevogt, J. Fielitz   +20 more
semanticscholar   +1 more source

IL-1β is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1β autostimulation. [PDF]

PLoS ONE, 2012
Many molecular and cellular abnormalities detected in the diabetic retina support a role for IL-1β-driven neuroinflammation in the pathogenesis of diabetic retinopathy.
Yang Liu, Montserrat Biarnés Costa, Chiara Gerhardinger   +2 more
doaj   +1 more source

N-GSDMD trafficking to neutrophil organelles facilitates IL-1β release independently of plasma membrane pores and pyroptosis

Nature Communications, 2020
Gasdermin-D (GSDMD) in inflammasome-activated macrophages is cleaved by caspase-1 to generate N-GSDMD fragments. N-GSDMD then oligomerizes in the plasma membrane (PM) to form pores that increase membrane permeability, leading to pyroptosis and IL-1β ...
Mausita Karmakar, Martin S Minns, Elyse Greenberg, Jose Diaz-Aponte, K. Pestonjamasp, J. Johnson, Joseph K. Rathkey, Derek W. Abbott, Kun Wang, F. Shao, S. Catz, G. Dubyak, E. Pearlman   +12 more
semanticscholar   +1 more source

Tumor Cell-Derived IL-1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer.

Cancer Research, 2020
Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy typified by a highly stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution and contributes to therapeutic resistance.
Shipra Das, Beny Shapiro, E. Vucic, Sandra Vogt, D. Bar-Sagi   +4 more
semanticscholar   +1 more source