Results 91 to 100 of about 447,090 (290)

Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration [PDF]

, 2016
Intervertebral disc degeneration is characterized by an imbalance between catabolic and anabolic signaling, with an increase in catabolic cytokines particularly IL-1β, a key regulator of IVD degeneration.
Bachmeier, Binch, Chujo, Clarke, Holzberg, Hoyland, Jiang, Jobin, Karppinen, Klawitter, Kondo, Krejci, Le Maitre, Le Maitre, Le Maitre, Le Maitre, Le Maitre, Le Maitre, Le Maitre, Li, Liang, Lyss, Ma, Mwale, Nasto, Nerlich, Osuka, Paz Aparicio, Phillips, Phillips, Phillips, Risbud, Roughley, Seguin, Solovieva, Solovieva, Spagnoli, Studer, Studer, Sun, Sun, Tian, Tolonen, Ulrich, Wang, Wuertz, Yu, Zhongyi   +47 more
core   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Association of proinflammatory cytokines and chemotherapy-associated cognitive impairment in breast cancer patients: a multi-centered, prospective, cohort study. [PDF]

, 2015
BackgroundExisting evidence suggests that proinflammatory cytokines play an intermediary role in postchemotherapy cognitive impairment. This is one of the largest multicentered, cohort studies conducted in Singapore to evaluate the prevalence and ...
Ang, SF, Cham, MT, Chan, A, Chay, WY, Cheung, YT, Dent, RA, Fan, G, Foo, KM, Ho, HK, Lee, JA, Loo, SK, Madhukumar, P, Ng, R, Ng, T, Ooi, WS, Shwe, M, Tan, YP, Wong, M, Yap, YS, Yong, WS   +19 more
core  

Silver nanoparticles inhibit VEGF-and IL-1β-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells [PDF]

, 2009
The aim of this study is to determine the effects of silver nanoparticles (Ag-NP) on vascular endothelial growth factor (VEGF)-and interleukin-1 beta (IL-1β)-induced vascular permeability, and to detect the underlying signaling mechanisms involved in ...
Eom, Soo Hyun, Gurunathan, Sangiliyandi, Kalishwaralal, Kalimuthu, Park, Jongsun, Sheikpranbabu, Sardarpasha, Venkataraman, Deepak   +5 more
core   +3 more sources

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8 [PDF]

, 2008
The cytokine interleukin (IL)-1β is a key mediator of the inflammatory response and has been implicated in the pathophysiology of acute and chronic inflammation.
Beyaert, Rudi, Haegman, Mira, Janssens, Sophie, Maelfait, Jonathan, Magez, Stefan, Schotte, Peter, Vercammen, Elisabeth   +6 more
core   +3 more sources

Hyperuricemia and Pro Inflammatory Cytokine (IL-1β, IL-6, and TNF-α)

Indonesian Journal of Rheumatology, 2018
Background. Rugerio et al 2006 reported that there were a positive correlation between the level of hyperuricemia and the level of IL-1β, IL-6, and TNF-α pro infl ammatory cytokines value. On the other hand, Choi et al reported a negative correlation between hyperuricemia and the level of pro infl ammatory cytokine in the late phase of hyperuricemia.
Hadi, Suyanto, Sudarsono, D, Suntoko, Bantar   +2 more
openaire   +2 more sources

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

Cytotoxic action of IL-1β against pancreatic islets is mediated via nitric oxide formation and is inhibited byN^G-monomethyl-l-arginine [PDF]

, 1992
Lars Bergmann, Klaus‐Dietrich Kröncke, Christoph V. Suschek, Hubert Kolb, Victoria Kolb-Bachofern   +4 more
openalex   +1 more source

The role of interleukin-1β in glucose metabolism during pregnancy and in gestational diabetes mellitus [PDF]

, 2017
Pregnancy leads to adaptations of the maternal metabolism and immune system. Increased levels of steroid hormones induce insulin resistance, leading to a glucose gradient from the mother to the fetus, which is modulated by changes in insulin secretion ...
Schulze, Friederike
core   +1 more source